拟除虫菊酯农药暴露对婴儿生长发育的影响

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (5): 409-412.

拟除虫菊酯农药暴露对婴儿生长发育的影响

郑明岚¹,齐小娟¹,邬春华¹,汪国权²,卢大胜²,常秀丽¹,周志俊¹

1 复旦大学公共卫生学院/公共卫生安全教育部重点实验室,上海 200032;
2 上海市疾病预防控制中心,上海 200336

收稿日期:2011-11-16 发布日期:2012-05-06 出版日期:2012-05-06
通讯作者: 周志俊,E-mail:zjzhou@fudan.edu.cn
作者简介:郑明岚(1978-),女,博士研究生,研究方向为农药毒理学
基金资助:
上海市公共卫生重点学科建设项目(08GWZX0303、08GWD20);复旦大学研究生创新基金(第十批)

Impact of pyrethroid pesticides exposure on development of one-year old infants

ZHENG Ming-lan¹,QI Xiao-juan¹,WU Chun-hua¹,WANG Guo-quan²,LU Da-sheng²,CHANG Xiu-li¹,ZHOU Zhi-jun¹

1 School of Public Health/Key Laboratory of Public Health Safety,Fudan University,Shanghai 200032,China;
2 Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China

Received:2011-11-16 Online:2012-05-06 Published:2012-05-06

摘要/Abstract

摘要： 【目的】探讨拟除虫菊酯农药暴露对婴儿生长发育的影响,为预防儿童农药中毒提供科学依据。【方法】选取江苏某县1岁婴儿449名,收集随机尿样检测拟除虫菊酯代谢物顺式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(cis-Cl₂CA)、反式-3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷-1-羧酸(trans-Cl₂CA)和3-苯氧基苯甲酸(3-PBA)水平,测量婴儿身长、体重、头围、胸围,用“0~6岁儿童发育筛查测验”(DST)评估婴儿智能发育状况,分析两者之间关系。【结果】研究对象尿样拟除虫菊酯代谢物cis-Cl₂CA、trans-Cl₂CA和3-PBA检出率分别为70.4%、97.6%和84.2%。按照总拟除虫菊酯浓度P₂₅、P₇₅分为低中高三组,不同暴露水平组之间婴儿的体重、胸围不完全相同,具有统计学意义(P<0.05),但身长、头围和发育商差异无统计学意义。多重线性回归分析亦提示尿拟除虫菊酯的浓度与体重有相关性(P<0.05)。【结论】拟除虫菊酯暴露对婴儿体重有一定的影响。

关键词: 拟除虫菊酯, 婴儿, 生长发育

Abstract: 【Objective 】 To examine associations between pyrethroid pesticides exposure and development in one-year infants. 【Methods】 449 one-year old infants in a county of Jiangsu Province were studied.Their spot urine were collected and pyrethroid pesticides exposure was assessed by measuring pyrethroid metabolites (cis-Cl₂CA,trans-Cl₂CA and 3-PBA).The Physical examination and the DST Scale were done and their relationship with pesticides exposure was evaluated. 【Results】 Pyrethroid metabolites (cis-Cl₂CA,trans-Cl₂CA and 3-PBA) were found among 70.4%,97.6% and 84.2% of these infants,respectively.The weight and the chest circumference among different pyrethroid metabolites levels was significiantly different,but not the body length,the head circumference and the development quotient.The pyrethroid metabolites level was associated with a decrement in weight by using multiple liner analysis. 【Conclusion】 Our findings suggest that exposure to pyrethroid negatively impacts on the weight of one-year infants.

Key words: pyrethroid pesticides, infants, growth and development

中图分类号:

R179

郑明岚,齐小娟,邬春华,汪国权,卢大胜,常秀丽,周志俊. 拟除虫菊酯农药暴露对婴儿生长发育的影响[J]. 中国儿童保健杂志, 2012, 20(5): 409-412.

ZHENG Ming-lan,QI Xiao-juan,WU Chun-hua,WANG Guo-quan,LU Da-sheng,CHANG Xiu-li,ZHOU Zhi-jun. Impact of pyrethroid pesticides exposure on development of one-year old infants[J]. journal1, 2012, 20(5): 409-412.

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