脐血IL-25、IL-33水平与早期婴儿湿疹的相关性研究

doi:10.11852/zgetbjzz2023-0115

中国儿童保健杂志 ›› 2024, Vol. 32 ›› Issue (2): 196-201.DOI: 10.11852/zgetbjzz2023-0115

脐血IL-25、IL-33水平与早期婴儿湿疹的相关性研究

杨云月^1,2, 王文革², 谭汉旭², 杨云彦², 卢旭俊²

1.北京中医药大学东直门医院儿科,北京 100700;
2.空军军医大学空军特色医学中心儿科,北京 100142

收稿日期:2023-06-11 发布日期:2024-02-21 出版日期:2024-02-10
通讯作者: 王文革,E-mail:1264516006@qq.com
作者简介:杨云月(1997-),女,重庆人,在读硕士研究生,主要从事儿童保健的研究。
基金资助:
北京市科技计划项目-首都临床特色应用研究(Z181100001718029)

Correlation of umbilical cord blood IL-25 and IL-33 with early infantile eczema

YANG Yunyue^1,2, WANG Wen'ge², TAN Hanxu², YANG Yunyan², LU Xujun²

1. Department of Pediatrics, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China;
2. Department of Pediatrics, Air Force Medical Center, Air Force Medical University, PLA, Beijing 100142, China

Received:2023-06-11 Online:2024-02-10 Published:2024-02-21
Contact: WANG Wen'ge, E-mail:1264516006@qq.com

摘要/Abstract

摘要： 目的探索新生儿脐血白细胞介素25(IL-25)、白细胞介素33(IL-33)水平与42d内婴儿湿疹发病的相关性,以期为早期婴儿湿疹的预防提供理论支持。方法选取2020年10月－2021年10月在空军特色医学中心妇产科出生的符合纳入标准的145例新生儿为研究对象,出生时收集脐带静脉血并测定脐血中IL-25及IL-33水平;42d后随访记录婴儿湿疹的发病情况和严重程度。结果在145例婴儿中,有79例患湿疹,患病率为54.5％。湿疹组脐血IL-25水平明显低于无湿疹组(Z=4.957,P<0.001),湿疹组脐血IL-33水平明显高于无湿疹组(Z=4.594,P<0.001),湿疹组有家族过敏史的概率明显高于无湿疹组(P<0.05)。Logistic回归分析结果显示,有家族过敏史、脐血IL-25低水平(<14.5pg/mL)、脐血IL-33高水平(>21.1pg/mL)是影响42d婴儿湿疹发生的危险因素(OR值分别为4.296、4.034、2.759,P<0.05),而出生体重与42d婴儿湿疹发病无关(P>0.05)。其中,脐血IL-33水平与分娩方式有关(P<0.05)。ROC曲线分析结果显示,最佳阳性截断值脐血IL-25为<14.0pg/mL(敏感度为62.0%,特异度为75.8%)、IL-33为>22.1pg/mL(敏感度为64.6%,特异度为69.7%)。Spearman相关性检验发现脐血IL-33水平与湿疹面积和严重程度指数(EASI评分)具有线性相关性(r=0.398,P<0.001)。结论家族过敏史、较低水平的脐血IL-25及较高水平的脐血IL-33是42d婴儿湿疹的重要影响因素,且较高水平的脐血IL-33会加重42d婴儿湿疹的严重程度。

关键词: 脐血, 婴儿, 湿疹, 白细胞介素25, 白细胞介素33

Abstract: Objective To investigate the correlation of the levels of interleukin-25 (IL-25) and interleukin-33 (IL-33) in cord blood with the development of infantile eczema within 42 days after birth, so as to provide theoretical support for the prevention of early infant eczema. Methods A total of 145 newborns who met the inclusion criteria and were born in the Obstetrics and Gynecology Department of the Air Force Special Medical Center from September 2020 to September 2021 were selected. Cord venous blood was collected at birth and the levels of IL-25 and IL-33 in cord blood were measured. The occurrence and severity of infantile eczema were recorded in 42 days. Results Among 145 infants, 79(54.5%) suffered from eczema. The level of IL-25 in cord blood in eczema group was significantly lower than that in non-eczema group (Z=4.957, P<0.001), and the level of IL-33 in cord blood in eczema group was significantly higher than that in non-eczema group (Z=4.594, P<0.001). The proportion of family history of allergy in the eczema group was significantly higher than that in non-eczema group (χ²=4.693, P<0.05). Logistic regression analysis showed that family history of allergy (OR=4.296), lower level of IL-25(＜14.5pg/mL) (OR=4.034) and higher level of IL-33(＞21.1pg/mL) (OR=2.759) in cord blood were risk factors for eczema (P<0.05), while birth weight was not associated with the onset of eczema in infants at 42 days (P>0.05). Meanwhile, the level of IL-33 in cord blood was related to the mode of delivery (P<0.05). ROC analysis showed that the optimized positive cutoff value was <14.0pg/mL for cord blood IL-25(sensitivity 62.0%, specificity 75.8%) and >22.1pg/mL for IL-33 (sensitivity 64.6%, specificity 69.7%). Spearman correlation test found that there was a linear correlation of the level of cord blood IL-33 with eczema area and severity index (EASI) score (r=0.398, P<0.01). Conclusion Family allergy history, lower level of cord blood IL-25 and higher level of cord blood IL-33 are important influencing factors of infant eczema in 42 days after birth, and higher level of cord blood IL-33 will aggravate the severity of early infantile eczema.

Key words: cord blood, infant, eczema, interleukin-25, interleukin-33

中图分类号:

R758.23

杨云月, 王文革, 谭汉旭, 杨云彦, 卢旭俊. 脐血IL-25、IL-33水平与早期婴儿湿疹的相关性研究[J]. 中国儿童保健杂志, 2024, 32(2): 196-201.

YANG Yunyue, WANG Wen'ge, TAN Hanxu, YANG Yunyan, LU Xujun. Correlation of umbilical cord blood IL-25 and IL-33 with early infantile eczema[J]. Chinese Journal of Child Health Care, 2024, 32(2): 196-201.

参考文献

[1] 陈旭, 苏士纹, 牛悦青. 过敏在中国的患病率及其对皮肤的影响——针对具有代表性的中国成年人群样本的流行病学研究[J]. 中华皮肤科杂志, 2021, 54(3):276-277.
Chen X, Su SW,Niu YQ. Prevalence of allergies in China and its effects on skin - An epidemiological study of a representative sample of Chinese adults[J]. Chin J Dermatol, 2021, 54(3):276-277.(in Chinese)
[2] 丁杨, 邱婷, 章恒. 301例婴幼儿湿疹影响因素分析[J]. 江苏医药, 2022, 48(6):606-608.
Ding Y,Qiu T, Zhang H.An analysis of influencing factors for eczema in 301 infants[J]. Jiangsu Med J, 2022, 48(6):606-608.(in Chinese)
[3] Hill DA, Spergel JM. The atopic march:Critical evidence and clinical relevance[J]. Ann Allergy Asthma Immunol, 2018, 120(2):131-137.
[4] Langan SM, Irvine AD, Weidinger S. Atopic dermatitis[J]. Lancet, 2020, 396(10247):345-360.
[5] Jain N. The early life education of the immune system:Moms, microbes and (missed) opportunities[J]. Gut Microbes, 2020, 12(1):1824564.
[6] Borowczyk J, Shutova M, Brembilla NC, et al. IL-25 (IL-17E) in epithelial immunology and pathophysiology[J]. J Allergy Clin Immunol, 2021, 148(1):40-52.
[7] Murdaca G, Greco M, Tonacci A, et al. IL-33/IL-31 axis in immune-mediated and allergic diseases[J]. Int J Mol Sci, 2019, 20(23):5856.
[8] 中华医学会皮肤性病学分会免疫学组. 湿疹诊疗指南(2011年)[J]. 中华皮肤科杂志, 2011, 44(1):5-6.
Immunology Group of Dermatology and Venereology Branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of eczema (2011)[J]. Chin J Dermatol, 2011, 44(1):5-6.(in Chinese)
[9] 赵辨. 湿疹面积及严重度指数评分法[J]. 中华皮肤科杂志, 2004, 37(1):3-4.
Zhao B. Eczema area and severity index scoring method[J]. Chin J Dermatol, 2004, 37(1):3-4.(in Chinese)
[10] 岳和欣, 曲翌敏, 湛永乐, 等. 婴幼儿湿疹影响因素分析:一项五省市的前瞻性队列研究[J]. 中华疾病控制杂志, 2022, 26(9):1005-1010.
Yue HX, Qu LM, Zhan YL, et al. Analysis of influencing factors of eczema in preschoolers in China:A prospective cohort study in five provinces[J]. Chin J Dis Control Prev, 2022, 26(9):1005-1010.(in Chinese)
[11] Shi H, Wan G, Wang T, et al. Prevalence and influencing risk factors of eczema among preschool children in Urumqi city:A cross-sectional survey[J]. BMC Pediatr, 2021, 21(1):347.
[12] Narla S, Silverberg JI. The role of environmental exposures in atopic dermatitis[J]. Curr Allergy Asthma Rep, 2020, 20(12):74.
[13] 周琴, 古桂雄, 叶侃, 等. 婴儿湿疹发病相关因素分析[J]. 中国儿童保健杂志, 2019, 27(11):1240-1242.
Zhou Q,Gu GX, Ye K, et al. Analysis on the influencing factors of infantile eczema[J]. Clin J Child Health Care, 2019, 27(11):1240-1242.(in Chinese)
[14] Kader HA, Azeem M, Jwayed SA, et al. Current insights into immunology and novel therapeutics of atopic dermatitis[J]. Cells, 2021, 10(6):1392.
[15] Patel NN, Kohanski MA, Maina IW, et al. Sentinels at the wall:Epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation[J]. Int Forum Allergy Rhinol, 2019, 9(1):93-99.
[16] Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, et al. Tissue signals imprint ILC2 identity with anticipatory function[J]. Nat Immunol, 2018, 19(10):1093-1099.
[17] Borowczyk J, Shutova M, Brembilla NC, et al. IL-25 (IL-17E) in epithelial immunology and pathophysiology[J]. J Allergy Clin Immunol, 2021, 148(1):40-52.
[18] Gamez C, Metcalfe J, Prescott SL, et al. Lower cord blood IL-17 and IL-25, but not other epithelial cell-derived cytokines are associated with atopic dermatitis in infancy[J]. Int Arch Allergy Immunol, 2021, 182(6):474-478.
[19] Wang D, Beck LA. Immunologic targets in atopic dermatitis and emerging therapies:An update[J]. Am J Clin Dermatol, 2016, 17(5):425-443.
[20] Ding W, Zou GL, Zhang W, et al. Interleukin-33:Its emerging role in allergic diseases[J]. Molecules, 2018, 23(7):1665.
[21] Li C, Maillet I, Mackowiak C, et al. Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells[J]. Cell Death Dis, 2017, 8(4):e2735..
[22] Jaworek AK, Szafraniec K, Doniec Z, et al. Pruritus characteristics in severe atopic dermatitis in adult patients[J]. Adv Exp Med Biol, 2021,1289:71-77.
[23] Ashley-Martin J, Dodds L, Arbuckle TE, et al. Predictors of interleukin-33 and thymic stromal lymphopoietin levels in cord blood[J]. Pediatr Allergy Immunol, 2015, 26(2):161-167.
[24] Tamagawa-Mineoka R, Okuzawa Y, Masuda K, et al. Increased serum levels of interleukin 33 in patients with atopic dermatitis[J].J Am Acad Dermatol, 2014, 70(5):882-888.

脐血IL-25、IL-33水平与早期婴儿湿疹的相关性研究

Correlation of umbilical cord blood IL-25 and IL-33 with early infantile eczema

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