孤独症谱系障碍儿童肠道菌群变化及作用机制

doi:10.11852/zgetbjzz2024-0960

中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (6): 638-642.DOI: 10.11852/zgetbjzz2024-0960

孤独症谱系障碍儿童肠道菌群变化及作用机制

祖姆热提·伊敏, 热娜·买买提, 王敏囡

新疆医科大学第一附属医院儿童保健科,新疆维吾尔自治区乌鲁木齐 830000

收稿日期:2024-08-15 修回日期:2024-12-12 发布日期:2025-06-05 出版日期:2025-06-10
通讯作者: 热娜·买买提,E-mail:krena95@aliyun.com
作者简介:祖姆热提·伊敏(1993—),女,住院医师,硕士学位,主要研究方向为神经发育障碍性疾病。
基金资助:
“天山英才”医药卫生高层次人才培养计划项目(TSYC202301A013)

Changes and mechanisms of gut microbiota in children with autism spectrum disorder

ZUMURETI·Yimin, RENA·Maimaiti, WANG Minnan

Department of Child Health Care, The First AFfiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, China

Received:2024-08-15 Revised:2024-12-12 Online:2025-06-10 Published:2025-06-05
Contact: RENA·Maimaiti,E-mail:krena95@aliyun.com

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)是以社交沟通障碍、重复刻板行为、兴趣狭窄为特点的神经发育障碍性疾病。最近研究发现,ASD儿童肠道菌群的组成成分及菌群丰度发生改变,而肠道菌群的改变可通过脑-肠-菌轴影响儿童的脑功能发育,导致行为发育障碍。目前不同的研究所报道的ASD患儿肠道菌群多样性、分类水平丰度的改变以及作用机制存在显著差异。因此,本文对ASD儿童中最常见的肠道菌群的改变情况以及在ASD儿童中的作用机制进行综述,为ASD与肠道菌群之间的相关性研究提供依据。

关键词: 孤独症谱系障碍, 肠道菌群, 脑-肠-菌轴, 儿童

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication, restrictive and repetitive behaviors, narrow interests.Recent studies have found that the composition and abundance of gut microbiota are changed in children with ASD, which affect the brain functional development of children through the "microbiota-gut-brain axis", resulting in behavioral development disorder.Currently, there are significant differences in the reported changes in gut microbiome diversity, taxonomic level abundance, and mechanisms of action among children with ASD in different research institutes.Therefore, this article reviews the changes and mechanism of the most common gut microbiota in children with ASD, in order to provide a basis for further study.

Key words: autism spectrum disorder, gut microbiota, microbiota-gut-brain axis, children

中图分类号:

R179

祖姆热提·伊敏, 热娜·买买提, 王敏囡. 孤独症谱系障碍儿童肠道菌群变化及作用机制[J]. 中国儿童保健杂志, 2025, 33(6): 638-642.

ZUMURETI·Yimin, RENA·Maimaiti, WANG Minnan. Changes and mechanisms of gut microbiota in children with autism spectrum disorder[J]. Chinese Journal of Child Health Care, 2025, 33(6): 638-642.

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孤独症谱系障碍儿童肠道菌群变化及作用机制

Changes and mechanisms of gut microbiota in children with autism spectrum disorder

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