四川省川东北地区6～17岁儿童青少年高尿酸血症患病情况及影响因素分析

doi:10.11852/zgetbjzz2023-0156

摘要/Abstract

摘要： 目的探讨四川省川东北地区6～17岁儿童青少年高尿酸血症(HUA)患病情况及其相关影响因素,为早期防治提供科学依据。方法采用回顾性研究的方法,收集川北医学院附属医院2017年1月1日—2021年12月31日15 739例6～17岁儿童青少年的临床资料,分析HUA患病情况,根据高尿酸血症诊断标准,将调查对象分为无高尿酸组(12 565例)、高尿酸组(3 174例)。采用多因素Logistic回归分析HUA患病影响因素。结果四川省川东北地区6～17岁儿童青少年HUA总体患病率为20.17%(3 174/15 739),其中男生患病率为26.53%(2 492/9 392),女生患病率为10.75%(682/6 347)。HUA患病率近5年总体呈增长趋势,其中2019—2020年增长较快;随着年龄的增长患病率呈上升趋势,以12岁为界点,男生在12岁及以后HUA患病率明显增加。多因素Logistic回归分析显示,男性(OR=2.308,95%CI:1.310~4.065,P=0.004)、年龄增长(OR=1.129,95%CI:1.019~1.251,P=0.020)、超重/肥胖(OR=1.080,95%CI:1.014~1.150,P=0.016)、血肌酐升高(OR=1.028,95%CI:1.008~1.049,P=0.006)、甘油三酯升高(OR=1.546,95%CI:1.133~2.108,P=0.006)、血钙升高(OR=12.723,95%CI:1.783~90.801,P=0.011)是HUA发生的独立危险因素。结论四川省川东北地区6～17岁儿童青少年HUA患病率较高,男生高于女生,其患病率随年龄增长而增加;HUA患病与性别、年龄、体质量指数、血肌酐、甘油三酯、血钙水平密切相关。

关键词: 儿童, 青少年, 高尿酸血症, 患病率

Abstract: Objective To investigate the prevalence of hyperuricemia (HUA) and its related factors in children and adolescents aged 6 - 17 years in Northeast Sichuan Province, so as to provide scientific basis for early prevention and treatment. Methods A retrospective study was conducted to collect the clinical data of 15 739 children and adolescents aged 6 - 17 years from January 1st, 2017 to December 31st, 2021 in the Affiliated Hospital of North Sichuan Medical College to analyze the prevalence of HUA. According to the diagnostic criteria of hyperuricemia, the participants were divided into no hyperuricemia group (n=12 565) and hyperuricemia group (n=3 174). Multivariate Logistic regression was used to analyze the influencing factors of HUA prevalence. Results The overall prevalence of HUA among children and adolescents aged 6 - 17 years in northeast Sichuan Province was 20.17% (3 174/15 739), with 26.53% (2 492/9 392) among boys and 10.75% (682/6347) among girls. The prevalence of HUA has shown an overall increasing trend in the past 5 years, with a faster increase in 2019—2020; the prevalence tended to increase with age, with 12 years old as the cut-off point, the prevalence of HUA increased significantly in boys aged 12 years or order. Multifactorial Logistic regression analysis showed that males (OR＝2.308, 95%CI:1.310 - 4.065, P=0.004), increasing age(OR＝1.129, 95%CI:1.019 - 1.251, P=0.020), overweight/obesity (OR＝1.080, 95%CI: 1.014 - 1.150, P=0.016), higher serum creatinine level(OR＝1.028, 95%CI:1.008 - 1.049,P=0.006), higher triglycerides level(OR＝1.546, 95%CI: 1.133 - 2.108,P=0.006), and higher serum calcium level(OR＝12.723, 95%CI:1.783 - 90.801,P=0.011) were risk factors for the development of HUA. Conclusions The prevalence of HUA in children and adolescents aged 6 - 17 years in Northeast Sichuan is higher in boys than in girls, and the prevalence increases with age. HUA is closely related to gender, age, body mass index, serum creatinine, triglyceride and serum calcium levels.

Key words: children, adolescents, hyperuricemia, prevalence

中图分类号:

R725

郭雪梅, 肖宁婷, 敬雪明, 朱朕男, 张和平. 四川省川东北地区6～17岁儿童青少年高尿酸血症患病情况及影响因素分析[J]. 中国儿童保健杂志, 2023, 31(11): 1185-1190.

GUO Xuemei, XIAO Ningting, JING Xueming, ZHU Zhennan, ZHANG Heping. Prevalence and influencing factors of hyperuricemia in children and adolescents aged 6 - 17 years in northeastern Sichuan province[J]. Chinese Journal of Child Health Care, 2023, 31(11): 1185-1190.

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