儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究

doi:10.11852/zgetbjzz2022-1360

中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (7): 707-712.DOI: 10.11852/zgetbjzz2022-1360

儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究

刘浩东¹, 李成¹, 赵敏², 席波¹

1.山东大学齐鲁医学院公共卫生学院流行病学系/山东大学儿童心血管研究中心,山东济南 250012;
2.山东大学齐鲁医学院公共卫生学院毒理与营养学系

收稿日期:2022-11-13 修回日期:2023-02-02 发布日期:2023-07-12 出版日期:2023-07-10
通讯作者: 席波,E-mail: xibo2010@sdu.edu.cn
作者简介:刘浩东(1997-),男,山东人,硕士研究生,主要研究方向为儿童心血管流行病学。
基金资助:
国家自然科学基金(81673195)

Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children

LIU Haodong¹, LI Cheng¹, ZHAO Min², XI Bo¹

1. Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University/ Children Cardiovascular Research Center of Shandong University, Jinan, Shandong 250012, China;
2. Department of Toxicology and Nutrition, School of Public Health, Cheeloo College of Medicine, Shandong University

Received:2022-11-13 Revised:2023-02-02 Online:2023-07-10 Published:2023-07-12
Contact: XI Bo, E-mail: xibo2010@sdu.edu.cn

摘要/Abstract

摘要： 目的探讨儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关系,为儿童高尿酸血症的防治提供科学依据。方法数据来源于2017年11月—2018年1月在山东省淄博市桓台县开展的“桓台儿童心血管健康队列”的基线调查。本研究共纳入信息完整的儿童1 202名,采用协方差分析比较儿童期腹型肥胖状态(正常腰围、腹型肥胖前期、腹型肥胖)儿童的尿酸水平,采用多因素Logistic回归模型分析儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症之间的关联。结果调整潜在协变量后,腹型肥胖前期[(289.7±80.6)μmol/L]、腹型肥胖[(332.2±87.8)μmol/L]儿童的尿酸水平均显著高于正常腰围儿童[(268.6±71.3)μmol/L](F=88.51,P<0.05)。与腰围正常儿童相比,儿童腹型肥胖前期(OR=2.71,95%CI:1.38～5.31)、腹型肥胖(OR=7.97,95%CI:4.61～13.76)儿童罹患高尿酸血症的风险增加(P<0.01)。采用腰围身高比指标进行腹型肥胖评价,得到相似的结果。结论儿童腹型肥胖及其腹型肥胖前期与高尿酸血症存在正向关联,提示今后应采取积极措施降低儿童腹型肥胖,从而预防儿童高尿酸血症的发生。

关键词: 腹型肥胖, 腹型肥胖前期, 高尿酸血症, 儿童

Abstract: Objective To examine the relationship of abdominal obesity and pre-abdominal obesity with hyperuricemia among children, in order to provide scientific basis for the prevention and treatment of hyperuricemia in children. Methods Data were from the baseline survey of the Huantai Childhood Cardiovascular Health Cohort Study conducted in Huantai County, Zibo City, Shandong Province from November 2017 to January 2018. A total of 1 202 children with complete data were included in this study. Covariance analysis was used to compare the difference in uric acid levels between children with normal waist circumference (WC), pre-abdominal obesity and abdominal obesity, and multivariate Logistic regression model was used to analyze the relationship of abdominal obesity and pre-abdominal obesity with hyperuricemia among children, using normal WC as reference. Results After adjusting for all potential covariates, uric acid levels in children with pre-abdominal obesity [(289.7±80.6)μmol/L] and abdominal obesity [(332.2±87.8)μmol/L] were significantly higher than those with normal WC [(268.6±71.3)μmol/L] (F=88.51, P<0.05). Compared with children with normal WC, children with pre-abdominal obesity (OR=2.71, 95%CI:1.38-5.31) and abdominal obesity (OR=7.97, 95%CI:4.61-13.76) were at an increased risk of hyperuricemia(P<0.01). The results were similar when using waist-to-height ratio to determine abdominal obesity. Conclusion There is a positive relationship of abdominal obesity and pre-abdominal obesity with hyperuricemia in children, suggesting that more efforts should be made to reduce childhood abdominal obesity, in order to prevent the occurrence of childhood hyperuricemia.

Key words: abdominal obesity, pre-abdominal obesity, hyperuricemia, children

中图分类号:

刘浩东, 李成, 赵敏, 席波. 儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究[J]. 中国儿童保健杂志, 2023, 31(7): 707-712.

LIU Haodong, LI Cheng, ZHAO Min, XI Bo. Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children[J]. Chinese Journal of Child Health Care, 2023, 31(7): 707-712.

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儿童期腹型肥胖及其腹型肥胖前期与高尿酸血症的关联研究

Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children

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