关键词: 缺氧缺血性脑病, 亚低温, 振幅整合脑电图, 新生儿

Abstract: Objective To explore the influence of some links in clinical mild hypothermia on the short-term prognosis of neonatal hypoxic-ischemic encephalopathy (HIE),in order to provide scientific basis for the clinical treatment of HIE. Methods Data of mild hypothermia treatment of 90 children with moderate and severe HIE admitted in Chengdu Women's and Children's Central Hospital from August 3rd,2016 to December 31st,2018 were collected and analyzed retrospectively.There were 73 children with moderate HIE and 17 children with severe HIE.All cases were divided into two groups according to different time windows (6 h vs.12 h),and the 6 h group was divided into two groups according to whether being rewarmed or not.Amplitude integrated electroencephalogram (aEEG) data,hospitalization time and general clinical characteristics were collected before and after mild hypothermia treatment. Results Mild hypothermia therapy was started 6 hours and 6-12 hours after resuscitation of asphyxia,and there was significant difference on aEEG graph score between different time windows(5.54±2.06 vs.3.00±1.41,t=2.27,P＜0.05).The aEEG graph score of the active cooling group was higher 24 hours after the end of mild hypothermia treatment than that of the warm-keeping rewarming group (4.63±2.06 vs.7.00±1.00,t=-2.37,P＜0.05). Conclusion s Mild hypothermia therapy as soon as possible after resuscitation of asphyxia can increase aEEG waveform score after treatment and improve short-term prognosis to some extent.Further follow-up is warranted for long-term prognosis.

Key words: hypoxic-ischemic encephalopathy, hypothermia therapy, amplitude integrated electroencephalogram, neonate