关键词: 骨密度, 血脂, 婴幼儿

Abstract: Objective To study the relationship between bone mineral density (BMD) and plasma lipid profiles in infants aged 6~12 months,in order to provide guidance for prevention and treatment of osteoporosis in infants. Methods Totally 164 individuals aged 6~12 months were randomly selected from infants undergoing regular physical examination in Maternal and Children's Health Care Hospital of Sanshui District from July 2015 to July 2016. Ultrasound BMD detection and plasma lipid tests were administrated. And participants were divided into 4 groups according to the results of ultrasound BMD, including 30 infants of normal BMD, 50 infants of mild BMD deficiency, 50 infants of moderate BMD deficiency, and 34 infants of severe BMD deficiency. The body length, weight and lipids profiles were compared among all groups. Pearson correlation test was used to analyze the correlation between Z value of BMD and age, body weight, body length, and blood lipid levels. Results There were significant differences on body length, low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) levels in infants among the four groups. Among them, TG level was significantly lower in group with abnormal BMD than in normal group. Pearson correlation analysis showed that Z value of BMD was positively correlated with male gender, age, body length, body weight, TC, LDL-C and TG levels (all P<0.05). Multi-linear regression revealed that TG remained significantly correlated with BMD Z value (β=0.549, P=0.002) after adjusted for age, gender, body weight, body length and TC. Conclusions The level of BMD in infants and young children is closely related to blood lipid levels and body length. So controlling the intake of saturated fatty acids rationally is of great significance to the growth and development as well as osteoporosis prevention in infants.

Key words: bone mineral density, plasma lipid profiles, infant