关键词: 癫痫, 伴中央颞区棘波, 智商

Abstract: Objective To study intelligence quotient influence factor in variant of benign childhood epilepsy with centrotemporal spikes (BECTS). Methods 15 cases of children with variant of BECTS in the pediatric ward of Xinjiang Uygur autonomous region people's hospital in January 2010 to January 2015 were researched retrospectively and the clinical features were analysed,which include clinical onset features,damage of intelligence and neuropsychological,electroencephalogram features,drug treatment response and so on.The correlation of language scale scores and clinical factors of children with variant of BECTS were analysed by correlation analysis.The t-test was used to compare the intelligence quotient of the unilateral and bilateral electroencephalogram abnormal discharges. Results 66.7% of variant of BECTS children showed a certain degree of learning disabilities,15 cases of electroencephalogram showed spine slow waves and spike waves which was discharged in central,top area and (or) posterior temporal area (Rolandic area) of unilateral or bilateral brain,which increased significantly after sleep and could partly reach to electrical status epilepticus during slow sleep(ESES).Language scale scores were correlated negatively with the duration of the spike slow wave index(SWI)≥50% in non rapid eye movement(NREM)term and the variant symptoms.There was no statistical significance in the difference of intelligence quotient between different abnormal discharged groups in unilateral and bilateral brain regions. Conclusions The children with variant of BECTS suffer cognitive impairment.The longer time of the duration of NREM SWI≥50% and variation symptom last,the more serious the cognitive dissonance is.The combined application of high doses methylprednisolone and the epilepsy drug is effective treatment for most variant of BECTS.

Key words: epilepsy, benign childhood epilepsy with centro-temporal spikes, intelligence quotient