关键词: 肉毒毒素, 脑性瘫痪, 超声定位, 双下肢痉挛, 康复治疗

Abstract: Objective To observe the clinical effect of ultrasound-guided botulinum toxin type A (BTX-A) injection combined with routine rehabilitation training on lower limbs dysmyotonia of spastic cerebral palsy children,and to provide evidence for clinical recovery treatment. Methods A total of 42 cases of Cerebral palsy in rehabilitation department of Anhui Provincial Children's Hospital from September 2014 to August 2015 were randomly divided into treatment group with 21 cases and control group with 21 cases,the control group received routine rehabilitation training (exercise therapy and physical therapy),treatment group was treated with BTX-A injection with ultrasound positioning and guidance,and began routine rehabilitation training next day.All patients were evaluated respectively before treatment and one month,three months,six months after treatment,the Modified Ashworth Scale(MAS)and the Gross Motor Function Measure(GMFM) were used as the standard to assess the degree of muscle spasm and gross motor function of lower limbs. Results After one month,three months and six months treatment,the MAS and GMFM scores of two groups were all significantly better than before (P<0.05);At the same time point,compared with the control group,the degrees of spasm and motor function in the treatment group were significantly improved (P<0.05);The MAS score improvement of treatment group between three months and six months after treatment was statistically significant (P>0.05),BTX-A effect had a certain time limit. Conclusion The use of BTX-A with ultrasound in the treatment of spastic cerebral palsy children can relieve the muscular tension,and improve the motor function.   

Key words: botulinum toxin, cerebral palsy, ultrasonic location, lower limbs spasticity, rehabilitation therapy