Table of Content

06 February 2013, Volume 21 Issue 2

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Follow-up study on flash visual evoked potentials in preterm infants from 1 to 36 months.

LI Bei,FENG Jing-jing,XU Xiu.

2013, 21(2):  118-121. 

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Objective To explore the evolution of flash visual evoked potentials (FVEP) in preterm infants from 1 to 36 months,and compare to the full-term. Method Using the Viking-Ⅳ visual electrophysiological testing device,the latency and amplitude values of the P2 main wave on FVEPs were recorded in infants longitudinally at 1,3,6,9,12,18,24 and 36 months. Results The trends of FVEPs were similar in the three groups of children,the latency of the P2 showed a significant decrease along with the age,but the amplitude had no difference.The latency of the P2 was more significantly delayed in VLBW group than in full-term group from 1 to 24 months,but there was no significant difference at 36 months; the LBW group showed the latency of the P2 wave was significantly delayed compared with the full-term group,only in 1~6 months. Conclusions Premature and LBW have the negative influence on the development of children's visual system,especially for VLBW.The follow-up evaluation of visual function state of this preterm group should be strengthened in school-age period.

Screening of SLC26A4 gene for newborns in Handan area.

YAO Gen-dong,LI Shou-xia,CHEN Ding-li,ZHANG Xiao-fang,FENG Hai-qin,GUO Li-li,SUN Cai-xia,YANG Zhi-ming.

2013, 21(2):  122-124. 

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Objective To explore necessity and feasibility for deafness gene SLC26A4 screening and provide experimental and theoretical basis for prenatal diagnosis. Methods 1 000 newborns were subjected to both newborn hearing screening using a transient evoked otoacoustic emission screening,and SLC26A4 gene mutations screening using the MassARRAY molecular weight array analysis system.The sanger sequencing method were used to verify the positive mutation sample. Results Of the 1 000 newborns,11 (1.1%)had OAE screening failure.A total of 10(1.0%) babies were found to have 1 mutated allele on the newborn genetic screening for deafness,9 (0.9%) of whom were heterozygous for IVS7-2A>G,1 (0.1%) heterozygous for c.1226G>A.All of them passed the hearing screening. Conclusions The newborn genetic screening for SLC26A4 may detected subjects with deafness-associated mutation,it might compensate for the inherent limitations of conventional newborn hearing screening,thus identifying the babies who may potentially have hearing loss.

Research of clinical outcome in 446 neonates with hyperthyrotropinemia.

LI Yu-fen,ZHANG Li-qin,HU Xiao-yan.

2013, 21(2):  125-126. 

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Objective To improve the treatment level of congenital hypothyroidism through researching the clinical outcome of neonatal hyperthyrotropinemia. Methods 446 hyperthyrotropinemia neonates were follow up whose concentration of thyrotropin were 5~20 mU/L and concentration of free thyroxine were normal.Their body growth level and thyroid function were evaluated in 3~6 years old. Results Among them,16 cases were hyperthyrotropinemia,429 cases were normal,and only one child were diagnosed permanent congenital hypothyroidism.Significant differences were found in concentration of thyrotropin between the outset and the end of follow-up. Conclusions With growing-up,the most of these neonates' thyroid function are normal.There should be exactitude follow-up with neonatal hyperthyrotropinemia.Congenital hypothyroidism should be diagnosed and treated as early as possible in hyperthyrotropinemia.

Relationships among p53 gene polymorphisms,environmental factors and low birth weight infants.

WU Shao-jing,LIU Wen-jing,ZHANG Hua,ZENG Hong,WANG Yun,ZHENG Ming-ci.

2013, 21(2):  127-130. 

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Objective To examine the relationships among p53 gene polymorphisms,environmental factors,and low birth weight infants. Methods A case-control study was conducted to collect the data of mothers and newborns,according to birth weight and gestational age,the infants were divided into healthy control group and low birth weight group (including preterm infants group and small for gestational age group).DNA from peripheral blood samples was examined by polymerase chain-restriction fragment length polymorphism (PCR-RFLP) method to detect the two p53 gene polymorphic situs p53codon72,p53PIN3 (rs1042522,rs17878362) and compared the genotype and allele frequency distribution in three groups. Results 1)Multivariate unconditional logistic regression analysis showed that the occurrence of low birth weight infants were associated with fetal gender,maternal education level,prenatal care and place of residence,and the regression coefficients were -0.710,1.055,0.825,-0.676,respectively.2)There was significant difference in the total distribution frequency of p53codon72 situs(χ²=19.182,P=0.001),but no association was detected between the low birth weight group and the healthy control group in p53PIN3 situs(χ²=0.566,P=0.754).The distribution frequencies of Pro/Pro genotype in p53codon72 situs in preterm infants group and small for gestational age group were significantly higher than those in normal birth weight infants group,individuals with the homozygous Pro/Pro genotype had increased risks of low birth weight[(OR=2.317,95%CI:1.290~4.162,P=0.002),(OR=2.805,95%CI:1.599~4.919,P=0.000)]. Conclusions Genetic and environmental factors and their interactions plays an important role in the incidence of low birth weight infants.p53codon72 situs polymorphism is related to low birth weight,and individuals allele of the p53 gene are at increased risk of low birth weight.

Clinical application of parenteral nutrition in premature infants.

WANG Jing,LIU Li,LIN Xiao-jie,XIAO Mi,XING Shan,CUI Jun-hao.

2013, 21(2):  131-133. 

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Objective To approach effects of different parenteral nutrition strategies on growth and development of premature infants. Methods A total of 168 premature infants were divided into two groups randomly.The infants in the treat group were given early and sufficient parenteral nutrition (PN),and those in the control group were given traditional PN.The body weight,hospital day and extrauterine growth restriction (EUGR) were recorded as well as blood glucose,blood electrolytes,blood lipid,bilirubin,bile acid,hepatic function and renal function. Results Compared to the control group,daily growth increments of body weight were significantly enhanced in the treat group,and the infants' body weight in the treat group recovered much more quickly than that in the control group.Besides,the length of hospital stay and the rate of EUGR were decreased in the treat group.The incidences of blood potassium,sodium and chloride disorder,and hypoglycemia in the control group were higher than those in the treat group,but the incidences of hyperglycemia and hypocalcemia in the treat group were higher than those in the control group(P<0.01).The levels of serum preprotein,albumin,globulin,blood lipid and blood urea nitrogen levels in the treat group were higher than those in the control group.There were no significant differences in the levels of bilirubin,bile acid and hepatic function between two groups(P>0.05). Conclusion Early and certain PN could promote growth and development of premature infants which may provide a safe strategy in PN of premature infants.

Unintentional-injury mortality among 0~14-year-old rural children:a meta-analysis.

SHI Xiu-quan,QI Yong-hong,CAO Bo-ling.

2013, 21(2):  134-136. 

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Objective To offer basic data to prevent the unintentional injuries through conducted a systematic evaluation of unintentional-injury mortality among 0~14-year-old rural children in China. Methods Studies published between 1990 and 2012 which consisting of unintentional-injury mortality were searched from CNKI,Weipu,Wanfang,Medline and Google Scholar databases.The pooled mortality was estimated using Meta-analysis.Subgroup analysis was undertaken by gender.Sensitivity analysis was also performed. Results Six valid papers were included for Meta-analysis,with a total sample size of 8 691 760.The pooled unintentional-injury mortality was 25.92 per 100 thousand (95%CI=19.33 to 32.51 per 100 thousand).Moreover,boys had significant higher unintentional-injury mortality (33.29 per 100 thousand) than girls (18.20 per 100 thousand).Sensitivity analysis suggested that the range of mortality changed little. Conclusion The unintentional-injury mortality among 0~14-year-old rural children in China is in high level,and rural boys are the major population for unintentional injury prevention owing to the significant gender difference.

Study on health-related quality of life and its influencing factors among children with recurrent respiratory tract infections.

SUN Li-jun,JIANG Xun,ZHANG Yu-hai,HAO Yuan-tao,YANG Xian-jun,WANG Chang-jun,SHANG Lei.

2013, 21(2):  137-140. 

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Objective To investigate Health-related Quality of Life(HRQOL) in children with recurrent respiratory tract infections (RRTI),and the impact of RRTI on their family,so as to provide scientific evidence for improving HRQOL of children with RRTI,and decreasing the impact of RRTI on their family. Methods Cross-sectional survey was carried out among 728 children aged 2 to 7.HRQOL was assessed by using the Chinese version of PedsQL^TM 4.0.The scores of HRQOL were compared between children with RRTI and healthy children,the consistency of scores for both caregivers proxy-report and children self-report was analyzed,and then the influencing factors on HRQOL of children with RRTI were explored. Results HRQOL scores of all the 4 dimensions and the total scale of PedsQL^TM 4.0 among RRTI children were significantly lower than those of healthy children (P<0.05).Family impact scores of all the dimensions and the total scale of family impact module among RRTI children were significantly lower than those of healthy children's family (P<0.05).Lower scores of family impact was significantly associated with lower PedsQL scores (P<0.05).The physical function,social function and total scores of children self-report were significantly higher than those of caregiver proxy-report (P<0.05).Multivariate analysis suggested that RRTI children's age,the relation between children and their parents,and the educational level of parents were primary influencing factors to children's HRQOL. Conclusions RRTI is harmful to RRTI children's HRQOL,and has negative impact on their family.Parents' sociological characteristics have a significant effect on HRQOL of children with RRTI.

Relationship of learning disabilities with both dietary patterns and dietary behaviors in children.

LIANG Xiao-hong,WANG Qing-xiong,WANG Xiao-bo,PENG Jie-ping,BU Rui-ying,LIU Cui-ting.

2013, 21(2):  141-143. 

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Objective To explore the relationship between learning disabilities(LD)and dietary patterns /dietary behaviors in children with LD,for improving their eating patterns and dietary behaviors so as to reveal the probable etiology of LD. Method The LD children(n=49)and control(n=50)were selected from 390 students in grade three to six in Guangzhou according with DSM-IV LD diagnostic criteria.The eating behaviors and patterns were investigated by questionnaires. Results The height and weight showed no significant difference between two groups(height,t=0.056;weight,t=0.75,all P>0.05).In dietary patterns ,eat more roughage was protective factors for LD(B=-0.549,OR=0.578).But more beans and bean products was risk factors for LD(B=0.429,OR=1.535).Both groups children's breakfast consisted of more grain and lack of milk or milk products,egg,meat,vegetable and fruit.The knowledge about healthy breakfast in control group was better than LD group(χ²=9.464,P=0.009).In dietary behaviors:less snacks and advisable food selected in breakfast were protective factors for LD(B=-0.694,OR=0.500,B=-0.328,OR=0.721).High family income was protective factors for LD(B=-0.753,OR=0.471)and the parents education background was poorer in LD than control group(χ²=20.067,P=0.000). Conclusions The breakfast eating pattern is not rational in two groups.The knowledge of nourishing breakfast in control children is better than LD children.Advisable breakfast choices is very important for LD children.Incorrect components of diet and not having adequate breakfast may be one of important environmental causes in forming LD.

Effects of erythropoietin on expression of Omi/HtrA2 and neuron apoptosis in brain of neonatal rats after asphyxia.

ZOU Li-le,LEI Xiao-ping,HAN Yi,MEI Xin-ming,YU Hong.

2013, 21(2):  144-147. 

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Objective To investigate the expression of Omi/HtrA2 and cell apoptosis in brain of neonatal rats after asphyxia and to evaluate the effects of erythropoietin (EPO) on it. Methods These SD rats aged 7 days were randomly divided into the following groups:control group,asphyxia group and EPO treatment group.Animals of asphyxia group and EPO treatment group were reproduced by normobaric asphyxia,then EPO treatment group immediately injected the rhEPO (5 000 U/kg) in intraperitoneal immediately after asphyxia,the control group and asphyxia group were injected the same volume of 0.9% sodium chloride,then the brain tissues from the rats in the both groups were taken at 6,12,24,48 and 72 hours after the asphyxia.The pathological changes of brain tissue observed by HE staining ,the apoptotic cells were detected by the TUNEL staining method and the Omi/HtrA2 protein expression was detected with the immunhistochemistry method. Results In asphyxia groups,the number of apoptotic cells and the expression of Omi/HtrA2 were higher than those in control group at each time group (P<0.05).But compared with asphyxia group,the number of apoptotic cells were higher and the expressions of Omi/HtrA2 were significantly decreased in EPO treatment group,and the differences were significant(P＜0.05),but all parameters were not restored to the level of control group(P＜0.05). Conclusion EPO can reduce the number of apoptotic cells by inhibiting the expression of Omi/HtrA2 in brain,and thus can play a protective role in asphyxia brain damage of neonatal rats.

Influence of glutamate receptor blocker on the apoptosis of hypoxic ischemic encephalopathy nerve cells.

YAN Na,AN Li,WANG Ping,ZHENG Yuan.

2013, 21(2):  148-151. 

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Objective To evaluate the inhibition of the glutamate receptor blocker(GYKI52466) on the apoptosis of hypoxic ischemic encephalopathy(HIE) newborn rats' nerve cells. Methods In vivo:The newborn rats are randomly divided into blank control group (N),hypoxicischemic brain damage group (H) and GYKI52466 intervention group (G).Drug was given after modeling,the rats' neurological abnormality and ultrastructural change were observed of each group.In vitro:The newborn rat's brain cells were made into unicellular suspension liquid and cultivated for 4 days.Then group N cells were cultivated in normal environment,group H cells were cultivated in oxygen-glucose deprivation(OGD) environment,and group G cells were added with GYKI52466 after cultivated in OGD environment.After 6 hours,compared the cells growth state of each group,and analyzed the apoptosis of brain cells by flow cytometric. Results In vivo:The neurological behavior observation showed that group G cells' neurological abnormality was improved than group H cells;the electron microscopy observation showed,group H cells' neurons nuclei structure was damaged,nuclear membrane was ruptured,and nucleoli had mild shrinks.But group G cells' structure tended to be completed.In vitro:compared with model groups,the GYKI52466 treatment group's apoptotic cells were fewer,the numerical value had extremely significant difference (P<0.001). Conclusions Glutamate receptor blocker GYKI25466 can effectively reduce the abnormal neural behavior performance and pathology change for newborn rat with HIE,inhibit the apoptosis of HIE newborn rats' nerve cells.This test confirmed that GYKI25466 has neuroprotective effects on brain cells.

Case-control study on influencing factors of perinatal birth defects in Kaifeng city.

WANG Shan,PAN Xin-juan,YU Zeng-li.

2013, 21(2):  161-163. 

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Objective To explore the influencing factors of perinatal birth defect,and provide scientific basis for intervention. Methods 468 perinatal birth defects infants were selected as case group,and 646 normal infants as control group.According to the birth date and sex matching principle,Logistic regression was used to analysis muti-factor. Results Regular intake of fish,shrimp,meat,eggs,milk and beans during pregnancy(OR=0.59),participating in pre-marital medical examination(OR=0.65) were the protective factors of birth defects.The habit of smoking and drinking(OR=2.02),the history of mother exposure to teratogenic factors(OR=1.63),medication during pregnancy(OR=4.23),exposure to harmful substances during pregnancy(OR=13.26),environment pollution sources near residence(OR=10.23) were the risk factors of birth defects. Conclusion The habit of smoking and drinking,the history of mother exposure to teratogenic factors,medication during pregnancy,exposure to harmful substances during pregnancy,environment pollution sources near residence are the main risk factors of birth defects.Primary prevention to the causes is important to reduce birth defects.

Predictive value of serum and urine S-100B protein for the outcome of neonatal hypoxic-ischemic encephalopathy.

MENG Shu-ying.

2013, 21(2):  163-165. 

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Objective To explore the clinical significance of serum and urine S-100B at different time points after birth in evaluating the severity and predicting the prognosis of neonatal hypoxic-ischemic encephalopathy (HIE). Method Serum and urine S-100B were measured in the 48 HIE neonates and 25 control neonates at day 1,3 and 7 after birth by ELISA and followed up at age of 1 year for HIE infants. Results The levels of serum and urine S-100B at day 1,3 and 7 after birth in the HIE group were significantly higher than in control group (P<0.01 or <0.05) and there was a close positive relationship between the level of S-100B protein and severity of HIE.The levels of serum S-100B at day 1 and 3 and urine S-100B at day 3 and 7 after birth in the abnormal group of outcome were significantly higher than normal group of outcome at age of 1 year (P<0.05 or <0.01).At a cut off >5 μg/L of serum S-100B protein and >3 μg/L of urine S-100B in there was a relatively good predictive value of S-100B for neonatal HIE at age of 1 year.The accuracy of serum S-100B>5 μg/L at day 1 and 3 after birth for predicting the prognosis of neonatal HIE was 88.1% and 77.3%,respectively and the accuracy of urine S-100B>3 μg/L at day 3 and 7 after birth for predicting the outcome of neonatal HIE was 90.5% and 85.7%,respectively.There was no significant difference between serum and urine S-100B for predicting the prognosis of neonatal HIE. Conclusions There is a close relationship between the level of serum and urine S-100B and the severity and the prognosis of neonatal HIE.S-100B protein shows significant value in predicting the prognosis of neonatal HIE.

Effect of early intervention on premature infants' General movements.

MA Liang,MENG Ling-dan,LV Pan-pan,SONG Guo-ying,LIU Fang,CAO Ai-hua.

2013, 21(2):  166-168. 

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Objective To investigate affect of early intervention on premature infants' general movements(GMs) during writhing period,and to guide early intervention clinically for preterm infants and improve neurodevelopmental outcome. Methods 1) The survey was carried among 285 premature infants during writhing period,who was in newborn department of pediatrics and followed up to our well baby clinic,from October 2011 to October 2012.According to the will of guardian,the cases were divided into early intervention group(n=125) and control group (n=160).2)Early intervention:the very early intervention,combining direct intervention and guiding parents for intervention,were given to early intervention group starting from newborn department of pediatrics.3) Numbers of different GMs during writhing period were compared in each group. Results The number of writhing movement in early intervention group was more than the control group,while the numbers of poor repertoire general movements (PR) and cramped-sychronised general movements (CS) were significantly fewer. Conclusion Very early intervention can reduce incidence rates of PR and CS,improve incidence rate of normal writhing movement.

Clinical and magnetic resonance imaging features findings of cerebral palsy.

ZHOU Tao-cheng,TONG Guang-lei,ZHANG Min,LI Si-nan,LI Hong.

2013, 21(2):  170-173. 

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Objective To investigate the relationship between the brain MRI and cerebral palsy (CP) types,gestational age,age and risky factors. Method All the 184 hospitalized CP cases were examined neurologically and their perinatal history were reviewed. Results MRI abnormalities were found in 163 of the 184 cases and abnormal rates of spastic diplegia,tetraplegia,hemiplegia,athetosis,hypotonia,ataxia and mixed were 82.1%,100%,100%,80.0%,80.6%,100% and 81.8%,respectively.Spastic tetraplegia was associated with extensive,bilateral,diffuse brain damage.38 of 55(69.1%) children with spastic diplegia had significant periventricular leukomalacia(PVL).Of the 20 children with hemiplegia,18 had unilateral lesions on neuroimaging.In different age groups,children less than 1 year of age had the highest rate of MRI abnormalities (93.6%),brain MRI abnormality rate decreased gradually with age.Risky factors in the higher rate of MRI abnormalities were:low birth weight,prematurity and hypoxia asphyxia. Conclusion MRI changes are closely related to CP types,gestational age,age and risky factors.

Analysis of epidemiological characteristics of mumps in Henan province from 2007 to 2011.

WANG Chang-shuang,MA Ya-ting,LU Ming-xia,ZHANG Xiao-xiao,ZHANG Yan-yang,GUO Wan-shen.

2013, 21(2):  176-178. 

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Objective To know mumps epidemiological characteristics in Henan province from 2007 to 2011,and to provide basis on mumps control. Method Mumps epidemiology with descriptive epidemiology was analyzed. Results A total of 81 235 cases of mumps were reported accumulatively in Henan province during the five years with the annual average incidence of 17.26/10⁵.The male to female ratio of the cases was 1.93∶1.The incidence peaks were in winter and spring.Up to 93.58% of the cases occurred in children aged 2~15 years old and 57.27% of the cases were students. Conclusions The incidence of mumps is still high in Henan Province.It is necessary to improve the child immunization program and vaccination rates,mumps screening is still needed to be strengthen.

Clinical effect of early intervention on high-risk infants.

LIN Wen-yu,CHEN Yu,Reyilamu·Yushanjiang,DU Wen-liang,FENG Tai-shan.

2013, 21(2):  179-181. 

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Objective To investigate the measures and clinical effect of early intervention on high risk infants. Methods A total of 253 high risk infants,who were treated in Maternity and Children Health Care Hospital between December 2008 and June 2010,were divided into invention group (125) and non-intervention group (128).Meanwhile,another (105) healthy children form a control group.The invention group of high risk infants was given regular medical examination and intelligence test as early intervention. Results The intelligence and motor development in intervention group of high-risk infants were significantly higher than those in non-intervention group,and the sequela incidence in intervention group was significantly lower than that in non-intervention group.These differences had statistical significances (P<0.05).The differences between intervention group and normal one in intelligence development,motor development and the sequela incidence had no statistical significances (P>0.05). Conclusions Early intervention in risky children helps their intelligence development,reducing the sequela incidence of nervous system and improving the patient's life quality.Early intervention pattern is family-centered,simply operated and acceptable.

Investigation of birth defects in Dongguan.

YI Quan-ying,ZHONG Bo-mao,LIU Jian-xin,SHI Si-xiong.

2013, 21(2):  181-184. 

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Objective To learn the variation trend and epidemiologic features of birth defects in Dongguan,and the conclusions can be used as the reference basis for formulating intervention program of birth defects. Method Statistical analysis was done to the data of birth defects monitoring of Dongguan during January 2008 to December 2011. Results 1)The incidence of infants with birth defects was 16.41‰.The prenatal diagnosis in birth defects rate was 19.32% over the period of four years.2) The first five main birth defects were congenital heart diseases,polydactyly,cleft lip and palate,congenital clubfoot,and neural tube malformations.3)The birth defect was related to residence origin of the parents,gender and number of neonates,as well as age of the pregnant women and live condition of perinatal.There were statistically significant for their differences(P all＜0.01). Conclusion The incidence of birth defects is higher than the national average in Dongguan.The prenatal diagnosis rate of birth defects is low,diagnosis should be raised for reducing the incidence of birth defects.

Analysis on birth weight of 206 165 newborns in Shanghai.

HUANG Jun,LIU Pu,LI Yun,WANG Na,XIA Hong,JIANG Qing-wu.

2013, 21(2):  184-187. 

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Objective To assess the birth weight of live births with gestational age from 28 to 42 weeks in Minhang District and identify the related factors to provide evidences for improving newborns' constitution. Methods Data on birth weight and other related factors for newborns born during Jan.2006-Nov.2011 were collected by the population-based electronic Health Records (eHR) system in Minhang District,Shanghai,China. Results A total of 206 165 live newborns were enrolled in this analysis.The mean and median birth weight were 3 343 g and 3 320 g for all newborns.Low birth weight rates were 0.6% and 0.9% of male and female newborns,while macrosomia accounted for 9.0% and 5.1%,respectively.The percentage of low birth weight and macrosomia,the average birth weight,gestational age and mother's age were significantly different between males and females (P<0.05).Mean birth weight also differed by sex,birth calendar year,gestational age,mother's age,mode of delivery,residence type and health condition of mother(P<0.05). Conclusion The average birth weight in live births is affected by several factors.Appropriate measures should be implemented to improve the situation.

Clinical analysis of pulmonary function test in children with asthma or cough variant asthma.

YUAN Jie,AN Shu-hua,GAO Wen-jie,DU Wen-jin,SHI Ling-ai,SUN Jun-feng,LI Qing-tao,YANG Fan,ZHANG Man,LI Quan-heng.

2013, 21(2):  187-190. 

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Objective To explore the clinical significances of pulmonary function test in children with asthma or cough variant asthma (CVA). Methods A total of 80 patients who were diagnosed asthma or CVA at outpatient of Hebei Children's Hospital were selected from May to November in 2010.They had been divided into three groups.Group A for 33 patients with acute asthma,whose average age was (7.96±2.12) years old;group B for 27 patients with asthma remission phase,whose average age was (7.97±1.91) years old;and group C for 20 patients with cough variant asthma,average age was (8.03±2.18) years old.30 children from healthy children were also randomly selected as group D,whose average age was (8.58±2.11) years old.All children were tested by the pulmonary function machine.There were seven pulmonary function indexes,such as forced vital capacity (FVC),forced expiratory volume in one second (FEV1),peak expiratory flow (PEF),forced expiratory flow after 25% (FEF25),forced expiratory low after 50% (FEF50),forced expiratory flow after 75% (FEF75),maximal mid-expiratory flow (MMEF75/25) and so on. Results All the pulmonary function indexes from group A and B and C were lower than those of group D,except PEF,FEF50,FEF75 of group B and C.Each pulmonary function indexes from group A were much lower than those of group B and C,but there was no significant difference between group B and C. Conclusion Pulmonary function test is important to assess the degree of airway obstruction,diagnose and evaluate severity for children with asthma or CVA.

Impact of TORCH intrauterine infection on neonatal behavioral neurological development.

WANG Rong,FAN Wei,LIU Zhen-huan.

2013, 21(2):  190-192. 

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Objective To explore the impact of TORCH intrauterine infection on neonatal behavioral and neurological development. Methods Choosing gestational age 37~42 weeks,umbilical cord blood or peripheral blood check TORCH series antibody one or more IgM(+),the mother in the prenatal screening or intrapartum monitoring TORCH series antibody one or more same pathogen IgM(+) of newborn as the infection team,while mother and neonatal umbilical cord blood and peripheral blood TORCH infection were checked all negative of 100 cases of neonatal as control group,two groups of newborn babies born in 48~72 hours,12~14 days,26~28 days were examined of NBNA score. Results Neonatal rubella virus,cytomegalovirus,herpes virus,toxoplasma infection rate had statistics significant differences (P<0.05),including cytomegalovirus infection rate was up to 1.48%,the lowest toxoplasma infection rate was 0.12%;Each time rubella virus and cytomegalovirus infection group of neonatal NBNA scores were lower than those of the control group (P<0.05),toxoplasma and herpes virus infection group of neonatal NBNA score and control group had no significant difference (P>0.05),NBNA score had no significant difference among the infection groups(P>0.05).The same infection group,neonatal NBNA scores in three periods had the significant differences (P<0.05). Conclusion TORCH intrauterine infection will affect the development of neonatal behavioral neurological development.

Survey and related factors of newborn disease screening in Hefei.

HU Hai-li,FU Su-lin,SHAO Zi-yu,XU Jun-yang,WANG Xue-ping.

2013, 21(2):  193-195. 

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Objective To analyse the causes of without disease screening and its related factors among newborn in Hefei,and to provide basis for follow-up health education. Methods A total of 2 170 parents whose baby was born on 1 May to 31 July of 2011 were recruited form different levels hospitals by stratified-cluster sampling method in Hefei.They completed the self-rating scale of disease screening. Results The rate of neonatal without screening was 14.05%,39% of those parents were willing to do neonatal metabolic screening subjectivly,but their babies did not making screening due to various objective reasons.61% of those parents were not willing to do neonatal metabolic screening subjectivly.Logistic regression analysis revealed that neonatal without screening was significantly related to mode of delivery,type of birth hospital,gestational age,score of neonatal screening questionnaire. Conclusion The phenomenon of neonatal without screening existed in different levels hospitals,and developing effective education programs to improve the preventive healthcare awareness of parents should be priority of neonatal screening.

Clinic analysis of 20 neonatal pneumothorax.

ZHANG Ya-qin,CUI Hui-ying,HUANG Xiao-mei,HU Xiao-chun,ZHANG Ming-hua.

2013, 21(2):  199-201. 

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Objective To analyze the pathogenic condition,clinical characters and treatments of neonatal pneumothorax. Method A retrospective study on 20 neonates born in Maternity and Child Health Care Hospital of Tongzhou District between September 2010 and September 2011. Results A total of 17 babies recovery got by conservative treatment and 2 babies were treated by puncture pumping air and closed chest drainage.1 infant died after completely rescue. Conclusions The incidence of neonatal pneumothorax was higher in term neonates,and relevant with delivery.To reduce selective cesarean section and improve the rescue technical could prevent the incidence of neonatal pneumothorax.

Retrospective study on onychomadesis linked to hand,foot and mouth disease.

XIAO Xin-cai,CHEN Chun,DING Peng,WANG Xun,GAN Li-qin,WANG Ming.

2013, 21(2):  201-204. 

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Objective To explore the attack rate of onychomadesis linked to hand,foot and mouth disease in Guangzhou. Method All lab-confirmed HFMD cases were follow up by home visit and telephone survey. Rerults 14 of the 356 HFMD cases had been attack by onychomadesis,attack rate were 3.93%,85.71% of them were HFMD cases caused by other enterovirus infections (non-EV71 and non-CoxA16),the average number of shed nails was 735 per case,HFMD in these 14 cases had started an average of 34 days before onset of onychomadeses and the changes on the nail. Conclusions Onychomadesis may occurred after HFMD,and most caused by other enterovirus infections.Further research are need to demonstrate whether or not onychomadesis is a long-term complication of HFMD.

Analysis of children's urinary iodine content of test results in Guilin city in 2011.

WU Qing-jie,LAN Lan,HE Yan-hong,FANG Fang,HUANG Ya-ming.

2013, 21(2):  204-206. 

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Objective To monitor and analyse the urinary iodine content of the frequency distribution of 8~10-year-old children at Guilin city and counties area and provide a scientific basis for lay down of appropriate interventions. Method The samples collected from children urine for testing basis on professional standard of health of P.R.China WS/T 107-2006. Results The 1 400 samples detection value of urinary iodine from children results showed.8~10 years old children urinary iodine level ＜50 μg/L ratio was 1.29% and ＜100 μg/L ratio was 5.29% and had up to the national iodine deficiency disorders elimination of the standard.In overall samples of urine,the urinary iodine levels ≥200 μg/L and above accounted for 73.64%(1 031/1 400),the urban sample of children ≥200 μg/L accounted for 66.20%(331/500) and the counties sample of children ≥200 μg/L accounted for 77.78% (700/900) and in which samples of children in four counties of ≥200 μg/L accounted for 86.75%(347/400). Conclusion The overall index of urinary iodine samples detected has reached the national standard,but there are high levels of phenomenon of children's urinary iodine in the counties.

Study of relationship between sleep quality,obesity and juvenile myopia.

LIN Lin,MAN Feng-tao,HU Nai-bao,LIU Hai-xia,JIA Gai-zhen,WAGN Ping-yu.

2013, 21(2):  206-209. 

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Objective To investigate the relationship among sleep quality,obesity and juvenile myopia. Method 1∶1 pair matched case-control study was conducted.177 pairs were matched by age and gender. Results Single factor analysis showed that the median of sleep quality of case group was higher than control group(Z=4.08,P<0.05).There was no statistical relation between juvenile myopia and other varibles such as obesity and overweight (P>0.05),but had correlation with parents myopia(χ²=49.150),the practice of reading in bed(χ²=13.561),reading distance between eyes and book(χ²=16.724),reading for 90minutes(χ²=13.701),taking part in air activities(χ²=13.263),and had dose-effect (P<0.05).Multiple logistic regression analysis showed that sleep quality (OR=1.21),parents myopia (OR=3.83),writing face down (OR=1.58) and reading distance between eyes and book (OR=1.59) were the risk factors of juvenile myopia. Conclusion Sleep quality,parents myopia,writing face down and reading distance between eyes and book are the disk factors of juvenile myopia.

Clinical research for sublingual immunotherapy of allergic asthma with dermatophagoides farinae drops.

LIU Yan-lin,TANG Su-ping,CHEN Shen,DONG Li,HUA Yun-han,GUO Yi-hua,LIN Shan,ZHANG Zhong-long.

2013, 21(2):  210-212. 

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Objective To observe and evaluate the efficacy and safety of two years sublingual Dermatophagoides Farinae Drops of specific immunotherapy in children with asthma. Methods 110 children aged 6~14 years old with acute exacerbation of mild-moderate allergic asthma from Department of Asthma bronchitis of Fuzhou Children's Hospital were selected and divided randomly into experimental group and control group of 55 cases each from October to December in 2009.The experimental group was given to sublingual Dermatophagoides Farinae Drops and conventional treatment in accordance with the GINA,control group was given conventional treatment in accordance with the GINA.IgG4,sIgE,skin prick test,FEV1% and the PEF of pulmonary function test,and the security were detected before and after treatment of 6 months or 12 months through 2-year follow-up. Results 1)The FEV1% of lung function,the value of IgG4 and the score of C-ACT in experimental group were higher than control group for 24 months treatment,and the score of the day night time asthma symptom was lower than the control group(P＜0.05);2) The dust mite skin test level changes,sIgE and the PEF values of lung function for 24 months treatment in the experimental group showed no differences with the control group(P＞0.05);3)The value of IgG4 in experimental group increased year by year between treatment for 12 months and 24 months,the difference of IgG4 between the experimental group and the control group was statistically significant (P<0.000 1); Conclusions The improvement of the lung function of children with allergic asthma,the score of the day night time asthma symptom and the score of C-ACT in experimental group are better than the control group.The IgG4 value is increased significantly year by year in the specific immunotherapy of sublingual dust mite for two years.Dermatophagoides Farinae Drops is a safe and effective treatment of allergic asthma in children-specific immunosuppressive drugs.

Linezolid treatment in drug-resistant gram-positive coccobacterial sepsis of newborn: a clinical analysis.

WANG Xiao-lei,SUN Hai-bin,CHEN Tao-ying,YU Min.

2013, 21(2):  213-214. 

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Objective To evaluate the clinical efficacy and safety of linezolid in the treatment of drug-resistant gram-positive coccobacterial sepsis of newborn. Methods Totally 30 neonates with drug-resistant gram-positive coccobacterial sepsis were enrolled.Clinical characteristics,pathogens,efficacy and safety of linezolid were evaluated. Results 30 resistant gram-positive strains were detected.Of these,there were 22 strains methicillin resistant coagulase negative staphylococci (MRCNS),5 strains enterococcus faecom and 3 strains staphylococcus aureus.Drug sensitivity results showed that all strains were resistant to penicillin,erythromycin,ampicillin and cefazoline,but were sensitive to linezolid.Among the MRCNS,staphylococcus epidermidis accounted for 12 strains,staphylococcus haemolyticus 6 strains,staphylococcus hominis 2 strains and staptococcus cohnii 2 strains.The clinical cure rate,significant rate,improvement rate and none effective rate were 73.3%,16.7%,6.7% and 3.3%,respectively.The overall effective rate was 90%.Overall pathogen eradication rate was 96.7%.The main adverse reactions included anemia in 2 cases,diarrhea in 2 cases (diarrhea plus granulocytopenia in 1 case),and nausea in 1 case.Liver and renal function showed no influence. Conclusion Linezolid is well-tolerated and effective in the treatment of drug-resistant gram-positive coccobacterial sepsis in neonates.

Research of effectively control of health education on children asthma.

QIN Hua-tao,WANG Wan.

2013, 21(2):  215-217. 

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Objective To achieve effective control of the objective of asthma through health education,improving asthma with GINA regimen (inhaled corticosteroid therapy) compliance. Methods For newly diagnosed patients and their parents (mainly parents) issued a self designed questionnaire.Content included basic knowledge of asthma,disease self-management,asthma morbidity situation in.6 months after health education,education for self control were researched. Results Before and after health education on treatment compliance and asthma related knowledge level of children and their parents had significant difference (P<0.05 ).After the education,asthma control indicators were significantly lower than before education(P<0.05 ). Conclusions The health education can promote children with asthma,and implement GINA standard treatment scheme,to improve treatment compliance,improve the quality of life,to achieve effective control of asthma.