Abstract: Objective To investigate Health-related Quality of Life(HRQOL) in children with recurrent respiratory tract infections (RRTI),and the impact of RRTI on their family,so as to provide scientific evidence for improving HRQOL of children with RRTI,and decreasing the impact of RRTI on their family. Methods Cross-sectional survey was carried out among 728 children aged 2 to 7.HRQOL was assessed by using the Chinese version of PedsQL^TM 4.0.The scores of HRQOL were compared between children with RRTI and healthy children,the consistency of scores for both caregivers proxy-report and children self-report was analyzed,and then the influencing factors on HRQOL of children with RRTI were explored. Results HRQOL scores of all the 4 dimensions and the total scale of PedsQL^TM 4.0 among RRTI children were significantly lower than those of healthy children (P<0.05).Family impact scores of all the dimensions and the total scale of family impact module among RRTI children were significantly lower than those of healthy children's family (P<0.05).Lower scores of family impact was significantly associated with lower PedsQL scores (P<0.05).The physical function,social function and total scores of children self-report were significantly higher than those of caregiver proxy-report (P<0.05).Multivariate analysis suggested that RRTI children's age,the relation between children and their parents,and the educational level of parents were primary influencing factors to children's HRQOL. Conclusions RRTI is harmful to RRTI children's HRQOL,and has negative impact on their family.Parents' sociological characteristics have a significant effect on HRQOL of children with RRTI.

Key words: recurrent respiratory tract infections, parent, quality of life, children

摘要： 目的 探讨反复呼吸道感染(recurrent respiratory tract infection,RRTI)对患儿及其家长健康相关生存质量的影响,为提高患儿及其家长生存质量提供参考。 方法 采用PedsQL^TM 4.0生存质量量表中文版,对728例2~7岁儿童及其家长进行调查。比较RRTI患儿及其家长与健康儿童及其家长的生存质量得分的差异,分析儿童自答问卷和家长代答问卷生存质量得分的一致性,并对患儿生存质量影响因素进行分析。 结果 RRTI患儿的生存质量各维度得分及总分均低于同龄健康儿童(P<0.05)。患儿家庭影响各维度得分及总分均低于同龄健康儿童家庭相应维度得分(P<0.05),家庭影响各维度得分与患儿生存质量得分呈正相关(P<0.05)。RRTI儿童自答问卷的生理功能、社交功能及总得分高于家长代答问卷得分(P<0.05)。多因素分析结果显示,患儿年龄、家长与患儿间的社会关系和家长文化程度与患儿生存质量得分有相关性(P<0.05)。 结论 RRTI对患儿生存质量及其家庭均存在一定危害,家长的社会学特征对患儿的生存质量有一定影响。

关键词: 反复呼吸道感染, 家长, 生存质量, 儿童