journal1 ›› 2012, Vol. 20 ›› Issue (12): 1101-1103.

Received:2012-07-18 Online:2012-12-06 Published:2012-12-06

睡眠干预模型在肥胖研究中的应用进展

杨倩,陈炉^*,陈喆^*,张泽彧,陈婷,戴斐,李生慧,郑志杰

上海交通大学医学院,上海 200025

通讯作者: 李生慧, E-mail:lsh9907@163.com;郑志杰, E-mail:zhengzj@sjtu.edu.cn注:^*并列第一作者。
作者简介:杨倩(1991-),女,辽宁人,在读本科生,主要研究方向为预防医学;陈炉(1991-),女,浙江人,在读本科生,主要研究方向为预防医学;陈喆(1992-),男,上海人,在读本科生,主要研究方向为预防医学
基金资助:
国家自然科学基金面上项目(81072314,30700670);上海市教委科研创新项目(13YZ034);2009年度上海交通大学医学院新百人计划;2012年度上海市公共卫生优秀学科带头人培养计划(GWDTR201222);上海交通大学医学院第六期大学生创新实践项目(2012033)

Abstract

摘要： 建立适宜的睡眠干预动物模型是研究睡眠的重要方法,尤其在探讨睡眠与疾病相关的病理机制时,动物模型的建立更显重要。本文概述了目前国际上在研究睡眠与肥胖相关机制领域采用较多的动物模型,如落水平台,滚筒法等主要的睡眠剥夺模型的建立及其应用范围、一些特殊的睡眠节律干预模型及基于已肥胖或食欲过剩小鼠模型的睡眠观察模型。由于睡眠与肥胖的相关性是目前热点的学术问题,本文可为该领域的相关研究提供技术参考。

关键词: 睡眠剥夺, 鼠科, 肥胖

CLC Number:

R749

杨倩,陈炉,陈喆,张泽彧,陈婷,戴斐,李生慧,郑志杰. 睡眠干预模型在肥胖研究中的应用进展[J]. 中国儿童保健杂志, 2012, 20(12): 1101-1103.

References

[1] 洪忻,李解权,梁亚琼.睡眠时间与肥胖关系的3年随访研究[J].中国慢性病预防与控制,2011,19(3):226-229.
[2] Broussard J,Brady MJ.The impact of sleep disturbances on adipocyt function and lipid metabolism[J].Best Pract Res Clin Endocrinol Metal,2010,24(5):763-773.
[3] Mueller AD,Pollock MS,Lieblich SE,et al.Sleep deprivation can inhibit adult hippocampal neurogenesis independent of adrenal stress hormones[J].AM J Physiol Requl Inteqr Comp Physiol,2008,294(5):1693-1703.
[4] 江帆,沈晓明,李生慧.短期完全性睡眠剥夺对幼年大鼠生理和器官功能的影响[J].中国实用儿科杂志,2007,22(3):205-207.
[5] 刘诗翔,汪洪,孔繁一.大鼠低氧低温睡眠剥夺模型建立及其行为学与大脑组织病理学变化[J].疑难病杂志,2011,10(11):849-851.
[6] 朱红莲,赵忠新.睡眠剥夺后神经元型一氧化氮合酶表达的变化及醒脑静对其影响[J].上海交通大学学报:医学版,2008,28(8):996-999.
[7] 熊雅婷,黄芳,徐丽华.五味子提取物对小鼠睡眠剥夺后脑组织自由基和一氧化氮的影响[J].中国药科大学学报,2006,37(3):255-258.
[8] 孙清梅,王彧,李冬艳.睡眠剥夺对青春期大鼠瘦素水平的影响[J].黑龙江医学,2009,33(9):663-664.
[9] 杨天阳,黄燕华,蔡昊旻.完全与不完全睡眠剥夺对小鼠免疫功能的影响[J].细胞与分子免疫学杂志,2010,26(2):115-117.
[10] Caron AM,Stephenson R.Energy expenditure is affected by rate of accumulation of sleep deficit in rats[J].Sleep,2010,33(9):1226-1235.
[11] 江倩,郭爱伟,周杰珑.睡眠干扰对雄性KM小鼠生殖健康的影响[J].畜禽业,2008,10(1):10-11.
[12] Arble DM,Ramsey KM,Bass J,et al.Circadian disruption and metabolic disease:findings from animal models[J].Best Practice & Research Clinical Endocrinology & Metabolism,2010,24(5):788-800.
[13] Salgado-Delgado R,Angeles-Castellanos M,Saderi N,et al.Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work[J].Endocrinology,2010,151(3):1019-1029.
[14] Salgado-Delgado R,Angeles-Castellanos M,Buijs MR,et al.Internal desynchronization in a model of night-work by forced activity in rats[J].Neuroscience,2008,154(3):922-931.
[15] Oishi K.Disrupted light-dark cycle induces obesity with hyperglycemia in genetically intact animals[J].Neuroendocrinology Letters,2009,30(4):458-461.
[16] Mavanji V,Billington CJ,Kotz CM.Sleep and obesity:A focus on animal models[J].Neuroscience and Biohavioral Reviews,2012,36:1015-1029.
[17] Ryu KY,Garza JC,Lu XY,et al.Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene[J].Proc Natl Acad Sci USA,2008,105:4016-4021.
[18] Broussard J,Matthew J.The impact of sleep disturbances on adipocyte function and lipid metabolism[J].Best Pract Res Clin Endocrinol Metal,2010,24(5):763-773.

睡眠干预模型在肥胖研究中的应用进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	TANG Yajun, LIU Xiumei. Research progress on dietary nutrition and intestinal flora in children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1232-1235.
[2]	LIN Duan, LIU Xiumei. Research progress on the role of histamine in the pathogenesis of tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1236-1240.
[3]	CHEN Yanhui, KE Zhongling. Psycho-behavioral intervention for tic disorder based on neurophysioloy [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1045-1049.
[4]	LU Yanting, CHEN Liangliang, LIU Xiumei. Mediating role of premonitory urge on the impact of comorbidity with attention-deficit/hyperactivity disorder on tic severity in children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1050-1054.
[5]	GAN Kaiyan, HUANG Anqi, ZHANG Ziyi, GUAN Luyang, WANG Fei, KE Xiaoyan. Prospective study of the stability of early diagnosis of autism spectrum disorder with positive screening results of Modified Checklist for Autism in Toddlers [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1076-1079.
[6]	YANG Fan, LI Qinghong, LI Yiming, YANG Shunbo, LI Wei, LYU Zhihai. Status of screen use and its association with core symptoms in children with autism spectrum disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1080-1084.
[7]	ZHANG Panpan, ZHAO Tingting, XIAO Xuwu. Correlation between intestinal flora and tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1091-1096.
[8]	QIU Jiaqi , ZHONG Xia, ZOU Shipu. Role of dopamine and its receptors in tic disorder in children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1097-1100.
[9]	XU Ying, SHI Haishui, ZHANG Huifeng, TIAN Xiaoyu. Role of GABAergic system in the pathogenesis and treatment of Tourette syndrome in children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1101-1105.
[10]	LI Zhonggui, WANG Haifei, HUANG Meilin, JING Jin. Cognitive impairments of children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1106-1110.
[11]	LI Shuai, HUANG Qijun, XIA Yu, LIU Zhenhuan. Meta-analysis of the correlation of prenatal, perinatal and environmental risk factors with childhood autism [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1122-1127.
[12]	JIANG Yanlin, WANG Junhong, LI Jialin, ZHAI Rui, JIANG Xiulei. Construction of a risk prediction scoring system for tic disorders in Chinese children based on Meta-analysis and external validation [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1128-1134.
[13]	ZHANG Liwen, QIN Xing, LI Juan, SONG Zixia, WU Weiwei. Efficacy of EEG biofeedback combined with methylphenidate hydrochloride in the treatment of childhood attention deficit hyperactivity disorder and its effect on cerebral blood flow and serum cortisol level [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1135-1139.
[14]	DONG Chao, ZHANG Linlin, ZHONG Yunyu, LIU Yun, LIU Juan, WANG Peng, WANG Yufeng, YANG Binrang, WU Zhaomin, LI Ying. Multidimensional executive function deficits in children with attention deficit hyperactivity disorder assessed by Cambridge Neuropsychological Test Automated Battery [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1149-1154.
[15]	WANG Yu, MA Xiaoping, YAO Rui, DU Tianju, LI Hua, LIU Li. Genetic etiology analysis of children with developmental delay and intellectual disabilities in Ningxia region [J]. Chinese Journal of Child Health Care, 2024, 32(9): 1008-1013.