Abstract: Objective To analysis the risk factors of cerebral palsy (CP) children with secondary epilepsy risk factors and provide reference for the prevention and treatment of CP children with epilepsy seizures. Methods Clinical data of 477 cases of children with CP in our hospital from May 2008 to January 2015 were retrospective analyzed.According to the children in hospital had seizures or not,children were divided into epilepsy group (case group) and the non-epilepsy group (control group),the general clinical data and imaging data of two groups were comparied,and the related factors were analyzed by Logistic regression analysis. Results In 477 patients with CP,86 cases merge epilepsy (18.0%),most (61.6%) children with epilepsy with tetraplegia,stiffness matrix cramps seizure was the main type of seizures (44.2%).Multiariable Logistic regression analysis suggested that low birth weight (OR=2.793,P<0.05),the softening of the brain (OR=3.185,P<0.05),intracranial hemorrhage (OR=3.581,P<0.05),the structure of the brain malformation (OR=5.839,P<0.05) were independent risk factors of CP children with epilepsy. Conclusions In children with CP,a softening of the brain,intracranial hemorrhage,low birth weight and brain structure abnormalities significantly increased the risk of epilepsy,which should be given clinical attention.   

Key words: epilepsy, Cerebral palsy, Children, Risk factors for

摘要： 目的 分析影响脑性瘫痪(CP)患儿合并癫痫的危险因素,为防治CP患儿癫痫的发作提供参考。方法 回顾性分析2008年5月-2015年1月我院477例CP患儿的临床资料,按照患儿入院时有无癫痫发作分为癫痫发作组(病例组)和无癫痫发作组(对照组),对两组患儿的一般临床资料及影像学资料等进行比较,并对脑性瘫痪患儿继发癫痫的相关因素进行二分类非条件Logistic回归分析。结果 纳入的477例CP患儿中有86例合并癫痫(18.0%),癫痫患儿以四肢瘫最多见(61.6%),强直阵挛性发作是癫痫发作的主要类型(44.2%);多因素Logistic回归分析提示低出生体重(OR=2.793,P＜0.05)、脑软化(OR=3.185,P＜0.05)、颅内出血(OR=3.581,P＜0.05)、脑结构畸形(OR=5.839,P＜0.05)是CP患儿合并癫痫的独立危险因素。结论 CP患儿中具有脑软化、颅内出血、低出生体重及脑结构畸形的发生癫痫的风险显著增高,应当给予临床重视。

关键词: 癫痫, 脑性瘫痪, 儿童, 危险因素