Control study on methylphenidate treatment in epilepsy comorbid attention deficit hyperactivity disorder
- LIU Ling,CHEN Yan-Hui,LIN Gui-xiu
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Abstract
Objective To investigate the clinical significance of methylphenidate treatment in epilepsy comorbid attention deficit hyperactivity disorder (ADHD) children in the disorder in children medication. Methods From our hospital specialist outpatients pediatric neurologist,58 cases of children epilepsy comorbid ADHD were collected and divided groups according to the type of epilepsy and whether taking methylphenidate .After 3 months of treatment .Electroencephalogram (EEG) abnormality rate change value,changes in seizure frequency and improvement of ADHD symptoms among the groups.Results After three months' treatment,between the groups of the same type of seizures were compared,EEG abnormality rate and the reduced value of seizure frequency were no statistical differences(P>0.05).Comparison of SNAP-IV scale scores in not taking methylphenidate groups before and after treatment was no statistical difference (P>0.05),while taking methylphenidate groups' SNAP-IV score was significantly decreased after treatment (P<0.05). Conclusion The study do not find the phenomenon that methylphenidate could aggravate epilepsy condition.Giving methylphenidate to epilepsy comorbid ADHD children is effective to improve the symptoms of hyperactivity impulsivity.
Key words
epilepsy / attention deficit hyperactivity disorders / comorbidity / methylphenidate
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References
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[2] Kaufmann R,Goldberg-Stern H,Shuper A.Attention-deficit disorders and epilepsy in childhood:incidence,causative relations and treatment possibilities[J].J Child Neurol,2009,24(6):727-733.
[3] Parisi P,Moavero R,Verrotti A,et al.Attention deficit hyperactivity disorder in children with epilepsy[J].Brain Dev,2010,32(1):10-16.
[4] 熊菲,杨凡.注意力缺陷多动障碍的药物治疗[J].中华妇幼临床医学杂志,2008,4(1):54-55.
[5] Yoo HK,Park S,Wang HR,et al.Effect of methylphenidate on the quality of life in children with epilepsy and attention deficit hyperactivitydisorder:and open-label study using an osmotic-controlled release oral delivery system[J].Epileptic Disord,2009,11(4):301-308.
[6] Dunn DW,Austin JK,Harezlak J,et al.ADHD and epilepsyin childhood[J].Dev Med Child Neurol,2003,5(1):50-54.
[7] Borgatti R,Piccinelli P,Montirosso R,et al.Study of attentional processes in children with idiopathic epilepsy by Conners Continuous Performance Test[J].J Child Neurol,2004,19(7):509-515.
[8] Hamoda HM,Guild DJ,Gumlak S,et al.Association between attention-deficit hyperactivity disorder and epilepsy in pediatricpopulations[J].Expert Rev Neurother,2009,9(12):1747-1754.
