Abstract: Objective To investigate the clinical significance of methylphenidate treatment in epilepsy comorbid attention deficit hyperactivity disorder (ADHD) children in the disorder in children medication. Methods From our hospital specialist outpatients pediatric neurologist,58 cases of children epilepsy comorbid ADHD were collected and divided groups according to the type of epilepsy and whether taking methylphenidate .After 3 months of treatment .Electroencephalogram (EEG) abnormality rate change value,changes in seizure frequency and improvement of ADHD symptoms among the groups.Results After three months' treatment,between the groups of the same type of seizures were compared,EEG abnormality rate and the reduced value of seizure frequency were no statistical differences(P>0.05).Comparison of SNAP-IV scale scores in not taking methylphenidate groups before and after treatment was no statistical difference (P>0.05),while taking methylphenidate groups' SNAP-IV score was significantly decreased after treatment (P<0.05). Conclusion The study do not find the phenomenon that methylphenidate could aggravate epilepsy condition.Giving methylphenidate to epilepsy comorbid ADHD children is effective to improve the symptoms of hyperactivity impulsivity.

Key words: epilepsy, attention deficit hyperactivity disorders, comorbidity, methylphenidate

摘要： 目的 研究癫痫共患注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童应用哌甲酯治疗的意义。方法 从本院小儿神经专科门诊中收集癫痫共患ADHD患儿58例,根据癫痫类型以及是否服用哌甲酯进行分组, 治疗3个月以后,比较同一癫痫发作类型服用哌甲酯与未服用哌甲酯组之间脑电图异常变化值、癫痫发作次数变化情况以及 ADHD症状改善情况。结果 同一癫痫发作类型服用哌甲酯与未服用哌甲酯组之间脑电图异常变化值、癫痫发作次数减少值比较,差异无统计学意义(P>0.05);各癫痫发作类型未服用哌甲酯组3个月治疗前、后SNAP-IV评分比较差异均无统计学意义(P>0.05),而服用哌甲酯组3个月治疗后SNAP-IV评分较前明显下降,差异有统计学意义(P<0.05)。 结论 哌甲酯对脑电图异常评分以及发作减少次数没有影响,未发现该药加重癫痫病情现象。

关键词: 癫痫, 注意缺陷多动障碍, 共患病, 哌甲酯