Pharmacogenetic impact on the methylphenidate-hydrocloride treatment in children with attention-deficit hyperactivity disorder

REN Miaomiao; CHEN Li

doi:10.11852/zgetbjzz2023-0489

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Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (3) : 296-300. DOI: 10.11852/zgetbjzz2023-0489

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Pharmacogenetic impact on the methylphenidate-hydrocloride treatment in children with attention-deficit hyperactivity disorder

REN Miaomiao, CHEN Li

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Abstract

Attention-deficit hyperactivity disorder (ADHD) is one of the most common chronic neurodevelopmental disorders in childhood.It is mainly manifested as inattention, hyperactivity, and impulsivity that are inconsistent with the development level, which may lead to multiple functional impairments and place heavy burdens on individuals, families, and society.Methylphenidate hydrochloride (MPH) is a first-line treatment drug for ADHD, which is widely used in clinical practice.However, some patients have no response to drug treatment and adverse reactions often cause premature termination of treatment.Introducing the concept of pharmacogenetics into MPH treatment may open new avenues for individualized interventions of ADHD.This paper aims to review the impact of pharmacogenetics on MPH treatment in children with ADHD and to provide references for clinical drug treatment and management.

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attention-deficit hyperactivity disorder / pharmacogenetics / methylphenidate-hydrocloride / pharmacokinetics / pharmacodynamics

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REN Miaomiao, CHEN Li. Pharmacogenetic impact on the methylphenidate-hydrocloride treatment in children with attention-deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2024, 32(3): 296-300 https://doi.org/10.11852/zgetbjzz2023-0489

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