Genetic factors, risk factors and pathogenesis of cerebral palsy comorbid epilepsy

doi:10.11852/zgetbjzz2023-0344

Abstract

Abstract: Compared to the general population, there is a higher prevalence of epilepsy in individuals with cerebral palsy (CP). Epilepsy serves as an indicator of CP severity and has a significant impact on the early survival and future quality of life of children with CP. Therefore, it is crucial to investigate the shared mechanisms underlying CP and epilepsy. This study aims to summarize the comorbidity of CP and epilepsy from genetic factors, risk factors, and pathophysiological mechanisms, in order to provide a reference for further research.

Key words: cerebral palsy, epilepsy, genetic factors, pathogenesis

摘要： 相较于一般人群,癫痫在脑性瘫痪(CP)人群中患病率很高,是CP严重程度的标志,也是影响CP儿童早期生存率和未来生活质量的重要因素,因此对于CP和癫痫的病因研究尤为重要。本研究将从遗传因素、危险因素以及病理生理机制方面总结CP和癫痫的共患病因,以期为今后研究提供参考。

关键词: 脑性瘫痪, 癫痫, 遗传因素, 发病机制

CLC Number:

GONG Chao, LIAN Beibei, LI Xuemei, ZHANG Peng, SONG Fanxu, GUO Jin. Genetic factors, risk factors and pathogenesis of cerebral palsy comorbid epilepsy[J]. Chinese Journal of Child Health Care, 2024, 32(2): 174-180.

公超, 连贝贝, 李雪梅, 张朋, 宋凡旭, 郭津. 脑性瘫痪共病癫痫的遗传因素、危险因素及发病机制[J]. 中国儿童保健杂志, 2024, 32(2): 174-180.

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