Abstract: Objective To evaluate the clinical efficacy of methylprednisolone combined with interferon for bronchiolitis. Methods A total of 182 patients with bronchiolitis were randomly divided into two groups:the control group of 91 patients were treated with anti-infectives,cough suppressants,expectorants,and oxygen therapy.The treatment group of 91 cases were received conventional treatment and methylprednisolone (1~2mg/kg,2~3 times /d for 3 days,reduction after 3 days) combined with interferon(1.0 μg /kg,one time/d for 3~5 days).The symptoms and signs were observed before and after the treatment. Results In the treatment group,the efficiency rate was 97.6%:in the control group,the efficiency rate was 82.4 %.There was a significant difference between the two groups in efficiency(P<0.01).Relieving wheezing,breathing difficulty,reduced cough time,and ablscultatory wheezing disappearing time were shorter in the treatment group compared to the control group(P<0.01). Conclusion Methylprednisolone combined with interferon for bronchiolitis is safe and help reduce healing time.

Key words: bronchiolitis, methylprednisolone, interferon, infants

摘要： 目的 探讨甲泼尼龙联合干扰素治疗毛细支气管炎的疗效分析,为临床诊治提供参考依据。 方法 将182例患儿随机分为治疗组和对照组各91例,对照组均给予改善通气、抗感染、止咳化痰等常规综合治疗;治疗组在对照组的基础上,给予静脉滴注甲泼尼龙1~2 mg/kg,2~3次/d,连用3 d、3 d后开始减量,并雾化吸入干扰素α-1b,1.0 μg/kg,1次/d,疗程均3~5 d;观察两组治疗前后咳嗽、喘憋、肺部体征等变化。 结果 治疗组和对照组总有效率分别为97.6 %、82.4%,两组比较差异有统计学意义(P<0.01);治疗组在咳嗽、喘憋和肺部喘湿鸣音消失、平均住院时间等方面均优于对照组,两组比较差异有统计学意义(P<0.01)。 结论 甲泼尼龙联合干扰素治疗毛细支气管炎疗效安全,能有效地缩短治愈时间。

关键词: 毛细支气管炎, 甲泼尼龙, 干扰素, 婴幼儿