Abstract

摘要： 近年来抽动障碍(tic disorder,TD)患病率逐渐升高。TD的病因及治疗学研究离不开动物模型。常用的TD动物模型包括多巴胺、5-羟色胺、兴奋性氨基酸、一氧化氮失调模型以及自身免疫模型、分离综合征模型、转基因模型等。这些动物模型通常只能部分地模拟TD患者的临床行为学和神经生化改变。目前国内TD模型以亚氨基二丙腈(IDPN)、2,5-二甲氧-4-碘苯-2-氨基丙烷(DOI)等化学因素诱发的动物模型为主,主要研究TD防治药物的作用机制;国外TD模型以自身免疫模型、基因工程模型为主,主要探究TD的发病机制。

CLC Number:

R749.94

车立纯综述, 衣明纪,刘秀梅审校. 抽动障碍动物模型研究进展[J]. 中国儿童保健杂志, 2013, 21(6): 615-617.

References

[1] Roessner V,Plessen KJ,Rothenberger A,et al.European clinical guidelines for Tourette syndrome and other tic disorders.Part II:pharmacological treatment[J].Eur Child Adolesc Psychiatry,2011,20(4):173-196.
[2] Huys D,Hardenacke K,Poppe P,et al.Update on the role of antipsychotics in the treatment of Tourette syndrome[J].Neuropsychiatric Disease and Treatment,2012,8(5):95-104.
[3] Steed E,Jones CA,McCreary AC.Serotonergic involvement in methamphetamine-induced locomotor activity:a detailed pharmacological study[J].Behav Brain Res,2011,220(1):9-19.
[4] 卫利,王素梅,崔霞,等.多发性抽动症动物模型的比较与评价[J].中华行为医学与脑科学杂志,2012,21(2):187-189.
[5] Lv H,Li A,Liu F,et al.Effects of gastrodin on the dopamine system of Tourette's syndrome rat models[J].Biosci Trends,2009,3(2):58-62.
[6] Bronfeld M,Israelashvili M,Bar-Gad I.Pharmacological animal models of Tourette syndrome[J].Neurosci Biobehav Rev,2012,7634 (12):163-7.
[7] Al Kadasah S,Al Mutairy A,Siddiquei M,et al.Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnomalities in rats[J].Behav Pharmacol,2009,20(4):356-360.
[8] 张如意,艾厚喜,张丽.拟抽动秽语综合症大鼠模型的复制及再评价[J].中国精神神经病杂志,2010,36(6):552-554.
[9] Li JJ,Li ZW,Li AY,et al.Abnormal expression of dopamine and serotonin transporters associated with the pathophysiologic mechanism of Tourette syndrome[J].Neurol India,2010,58(4):523-529.
[10] 姚阳,刘坤.DOI诱导的Wistar大鼠头部抽动模型脑内VMAT2的表达[J].解剖科学进展,2011,17(1):48-50.
[11] Mueller PJ,Mischel NA.Selective enhancement of glutamate-mediated pressor responses after GABA(A) receptor blockade in the RVLM of sedentary versus spontaneous wheel running rats[J].Front Physiol,2012,3(12):447-455.
[12] Nazari QA,Mizuno K,Kume T.In vivo brain oxidative stress model induced by microinjection of sodium nitroprusside in mice[J].Pharmacol Sci,2012,120(2):105-111.
[13] Yaddanapudi K,Hornig M,Serge R,et al.Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection[J].Mol Psychiatry,2010,15(7):712-726.
[14] Loiselle CR,Lee O,Moran TH,et al.Striatal microinfusion of Tourette syndrome and PANDAS sera:failure to induce behavioral changes[J].Mov Disord,2004,19(4):390-396.
[15] Hoffman KL,Hornig M,Yaddanapudi K,et al.A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection[J].J Neurosci,2004,24(7):1780-1791.
[16] Lovic V,Keen D,Fletcher PJ,et al.Early-life maternal separation and social isolation produce an increase in impulsive action but not impulsive choice[J].Behav Neurosci,2011,125(4):481-491.
[17] Meng Q,Li N,Han X,et al.Peri-adolescence isolation rearing alters social behavior and nociception in rats[J].Neurosci Lett,2010,480(1):25-29.
[18] Marsden CA,King MV,Fone KC.Influence of social isolation in the rat on serotonergic function and memory--relevance to models of schizophrenia and the role of 5-HT6 receptors[J].Neuropharmacology,2011,61(3):400-407.
[19] Cain ME,Mersmann MG,Gill MJ,et al.Dose-dependent effects of differential rearing on amphetamine-induced hyperactivity[J].Behav Pharmacol,2012,23(8):744-753.
[20] Cáceda R,Binder EB,Kinkead B,et al.The role of endogenous neurotensin in psychostimulant-induced disruption of prepulse inhibition and locomotion[J].Schizophr Res,2012,136(1-3):88-95.
[21] Swerdlow NR,Bongiovanni MJ,Tochen L,et al.Separable no radrenergic and dopaminergie regulation of prepulse inhibition in rats:implications for predicttive validity and Tourette syndrome[J].Psychopharmacology,2006,186(2):246-254.
[22] Nordstrom EJ,Burton FH.A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry[J].Mol Psychiatry,2002,7(6):617-625.

抽动障碍动物模型研究进展

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	TANG Yajun, LIU Xiumei. Research progress on dietary nutrition and intestinal flora in children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1232-1235.
[2]	LIN Duan, LIU Xiumei. Research progress on the role of histamine in the pathogenesis of tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(11): 1236-1240.
[3]	CHEN Yanhui, KE Zhongling. Psycho-behavioral intervention for tic disorder based on neurophysioloy [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1045-1049.
[4]	LU Yanting, CHEN Liangliang, LIU Xiumei. Mediating role of premonitory urge on the impact of comorbidity with attention-deficit/hyperactivity disorder on tic severity in children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1050-1054.
[5]	GAN Kaiyan, HUANG Anqi, ZHANG Ziyi, GUAN Luyang, WANG Fei, KE Xiaoyan. Prospective study of the stability of early diagnosis of autism spectrum disorder with positive screening results of Modified Checklist for Autism in Toddlers [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1076-1079.
[6]	YANG Fan, LI Qinghong, LI Yiming, YANG Shunbo, LI Wei, LYU Zhihai. Status of screen use and its association with core symptoms in children with autism spectrum disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1080-1084.
[7]	ZHANG Panpan, ZHAO Tingting, XIAO Xuwu. Correlation between intestinal flora and tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1091-1096.
[8]	QIU Jiaqi , ZHONG Xia, ZOU Shipu. Role of dopamine and its receptors in tic disorder in children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1097-1100.
[9]	XU Ying, SHI Haishui, ZHANG Huifeng, TIAN Xiaoyu. Role of GABAergic system in the pathogenesis and treatment of Tourette syndrome in children [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1101-1105.
[10]	LI Zhonggui, WANG Haifei, HUANG Meilin, JING Jin. Cognitive impairments of children with tic disorder [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1106-1110.
[11]	LI Shuai, HUANG Qijun, XIA Yu, LIU Zhenhuan. Meta-analysis of the correlation of prenatal, perinatal and environmental risk factors with childhood autism [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1122-1127.
[12]	JIANG Yanlin, WANG Junhong, LI Jialin, ZHAI Rui, JIANG Xiulei. Construction of a risk prediction scoring system for tic disorders in Chinese children based on Meta-analysis and external validation [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1128-1134.
[13]	ZHANG Liwen, QIN Xing, LI Juan, SONG Zixia, WU Weiwei. Efficacy of EEG biofeedback combined with methylphenidate hydrochloride in the treatment of childhood attention deficit hyperactivity disorder and its effect on cerebral blood flow and serum cortisol level [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1135-1139.
[14]	DONG Chao, ZHANG Linlin, ZHONG Yunyu, LIU Yun, LIU Juan, WANG Peng, WANG Yufeng, YANG Binrang, WU Zhaomin, LI Ying. Multidimensional executive function deficits in children with attention deficit hyperactivity disorder assessed by Cambridge Neuropsychological Test Automated Battery [J]. Chinese Journal of Child Health Care, 2024, 32(10): 1149-1154.
[15]	WANG Yu, MA Xiaoping, YAO Rui, DU Tianju, LI Hua, LIU Li. Genetic etiology analysis of children with developmental delay and intellectual disabilities in Ningxia region [J]. Chinese Journal of Child Health Care, 2024, 32(9): 1008-1013.