Objective To study the diagnosis value of ambulatory electroencephalogram (AEEG) and brain auditory evoked potential (BEAP) in newborns with hypoxic ischemic encelphalopathy(HIE). Methods A total of 47 newborns diagnosed hypoxic ischemic encelphalopathy from January 2011 to December 2012 in Shengjing hospital neonatal wards were selected as case group,while the jaundice newborns as control group.AEEG and BAEP examinations were conducted and then analyzed comparatively. Results All the newborns` AEEG in the case group were abnormal,the rate was 100%,of which 22 were mild,17 were moderate and 9 were serious.There was damatic difference between the two groups.And the BAEP abnormal rate was 55.3%,of which 21 were mild and 5 were moderate. Conclusion AEEG and BAEP are both noninvasive nerve electrophysiology examinations,and they are regarded as important methods for the early detection of brain and brainstem damage in newborns with HIE.