Objective To analyze the effect of thyroid hormone on the prognosis of newborns with mild hyperthyrotropinemia, so as to provide theoretical basis for clinical treatment of mild neonatal hyperthyrotropinemia. Methods Clinical data of newborns with mild hyperthyrotropinemia admitted to the Neonatal Intensive Care Unit in Fujian Provincial Hospital were retrospectively analyzed. According to treatment or not, newborns were divided into treatment group and control group. The rate of permanent hypothyroidism, Gesell Developmental Schedules(GDS) score, body length, body weight and normal thyroid function in different stages were compared between the treatment group and control groups. Results A total of 470 infants with mild hyperthyrotropinemia were enrolled in the study, including 182 cases in treatment group and 288 cases in control group. The gestational age, birth weight, body length and head circumference of newborns in the treatment group were significantly lower than those in control group(Z=-6.600,-6.140,-5.444,-6.537, P＜0.05).The prevalence rates of neonatal infection, neonatal respiratory distress syndrome, bronchopulmonary dysplasia and critical condition in the control group were significantly higher than those in the control group(χ2=8.755, 34.285, 19.044, 29.235, P＜0.05). Finally, 148 pairs of cases were matched successfully by propensity score matching (PSM). There was no significant difference in baseline data between the two groups (P>0.05). After PSM, neither the treatment group nor the control group had cases developing permanent hypothyroidism, and there were no significant differences in the score of GDS and body weight between the two groups (P>0.05). The number of cases whose thyroid function returned to normal within 1 month and 3 months in the treatment group was significantly less than that in the control group(χ2=21.765,8.601, P＜0.05). Conclusions Thyroid hormone supplementation in newborns with mild hyperthyrotropinemia can prolong the duration of thyroid function level returning to normal range within three months. Therefore, it is not recommended to supplement mild hyperthyrotropinemia infants with thyroid hormoneation.
Key words
hyperthyrotropinemia /
permanent hypothermia /
Gesell Developmental Schedules /
neonates
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