【Objective】 To understand the status and epidemiological characteristics of live birth weight in Hainan province and provide proper intervention methods to decision-making department. 【Methods】 A retrospective survey was used,and data were collected from the medical certificate of birth system of Hainan province. 【Results】 103 627 live births were analyzed and their mean live birth weight was (3 101±442 )g.Live birth weight was higher in the urban areas (3 217 g) than that in the rural area (3 084 g)(t=31.2,P<0.001),the highest in the east areas (3 139 g),middle in the west areas (3 061g) and the lowest in the middle areas (3 057 g)(F=427.1,P<0.001),with a decreasing trend.Live birth weight in the first class (3 137 g),the second-class (3 086 g) and third-class rural areas (3 061 g) decreased significantly(F=131.8,P<0.001).Live birth weight with Han's parents (male 3 172,female 3 055) was the highest and with the parents in minor ethnics (male 3 041,female 2 953) was the lowest.The ratio of low birth weight was lower in the urban areas (4.8%) than that in the rural area (6.1%)(χ²=38.2,P<0.001) and the incidence of fetal macrosomia was higher in the urban areas (5.2%) than that in the rural area (2.5%)(χ²=327.5,P<0.001). 【Conclusions】 Generally,the average live birth weight in Hainan province was lower than WHO standard.A big difference in the average live birth weight between regions with varied economic development and health care condition was observed.An intervention measure should be implemented in the poverty-stricken rural areas to increase their average live birth weight.