Analysis of the relationship of insulin-like growth factor-1 with the growth velocity and feeding of healthy infants
- WANG Xin-li, KANG Xin, GUAN Yu-hong, QI Jing, WANG Zhao-hong, ZHANG Shu-li
Author information
+
History
+
Abstract
【Objective】 To analyze the variation trends of serum IGF-1 levels in healthy infants and the relationship of IGF-1 with the growth velocity and feeding pattern of infants. 【Methods】 IGF-I concentrations were measured in 544 healthy infants. They were all full term and appropriate for gestational age infants, and were born between 2006 and 2008 in the Third Hospital of Peking University, with their height and weight measured and their feeding patterns recorded every 1 to 2 months in this hospital. At the time of analyzing the relationship of IGF-1 levels with the growth velocity and feeding, gender and number of months after birth were adjusted. 【Results】 Serum IGF-1 level witnessed a small peak in 2-3 months after birth, dropped rapidly thereafter, reached the lowest point in 7~8 months after birth, and slowly increased in the following months. Serum IGF-1 levels were significantly higher in females [112.65 ng/mL, 95%CI:91.82~133.89] than in males [74.38 ng/mL,95%CI:53.14~95.61,P＜0.05] during early infancy. Infants receiving breast milk had lower serum IGF-I levels[(66.94±45.85) ng/mL] than infants receiving formula [(72.56±36.55)ng/mL] or both [(79.89±51.79)ng/mL;P=0.019]. IGF-1 levels were positively associated with growth velocity(P<0.01). 【Conclusions】 This study provided the variation trend for IGF-1 levels during infancy. IGF-1 may play a key role in regulation of infant statural growth and was influenced by the feeding pattern.
Key words
insulin-like growth factor-1 / growth and development / feeding / infant
{{custom_sec.title}}
{{custom_sec.title}}
References
[1] Rogers I, Metcalfe C, Gunnell D, et al. Insulinlike growth factor-I and growth in height, leg length, and trunk length between ages 5 and 10 years[J]. J Clin Endocrinol Metab,2006,91: 2514-2519.
[2] Rosenfeld RG. Molecular mechanisms of IGF-I deficiency[J]. Horm Res,2006,65(S):15-20.
[3] Haspolat K, Ece A, Gürkan F, et al. Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition[J]. Clin Biochem,2007,40:201-205.
[4] 中华人民共和国卫生部妇幼保健与社区卫生司,九市儿童体格发育调查研究协作组,首都儿科研究所. 2005年中国九市7岁以下儿童体格发育调查研究[M]. 北京:人民卫生出版社,2008:89-100.
[5] Van der Eerden BC, Karperien M, Wit JM. Systemic and local regulation of the growth plate[J]. Endocr Rev, 2003,24:782-801.
[6] Fernandez AM, Dupont J, Farrar RP,et al. Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle[J]. J Clin Invest,2002,109:347-355.
[7] Scavo LM, Karas M, Murray M, et al. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes[J]. J Clin Endocrinol Metab, 2004,89:3543-3553.
[8] Anders J. Serum levels of insulin-like growth factor I and its binding proteins in health and disease[J]. Growth Hormone & IGF Research, 2003,13:113-170.
[9] Low LC, Tam SY, Kwan EY, et al. Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life[J]. Pediatr Res, 2001,50(6):737-742.
[10] Qin LQ, He K, Xu JY. Milk consumption and circulating insulin-like growth factor-I level: a systematic literature review[J]. Int J Food Sci Nutr, 2009,60 (S7):330-340.
[11] Allen NE, Appleby PN, Davey GK, et al. Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men[J]. Br J Cancer, 2000,83 (1):95-97.
[12] Ong K, Langkamp M, Ranke MB, et al. Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study[J]. Am J Clin Nutr, 2009,90:156-161.
[2] Rosenfeld RG. Molecular mechanisms of IGF-I deficiency[J]. Horm Res,2006,65(S):15-20.
[3] Haspolat K, Ece A, Gürkan F, et al. Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition[J]. Clin Biochem,2007,40:201-205.
[4] 中华人民共和国卫生部妇幼保健与社区卫生司,九市儿童体格发育调查研究协作组,首都儿科研究所. 2005年中国九市7岁以下儿童体格发育调查研究[M]. 北京:人民卫生出版社,2008:89-100.
[5] Van der Eerden BC, Karperien M, Wit JM. Systemic and local regulation of the growth plate[J]. Endocr Rev, 2003,24:782-801.
[6] Fernandez AM, Dupont J, Farrar RP,et al. Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle[J]. J Clin Invest,2002,109:347-355.
[7] Scavo LM, Karas M, Murray M, et al. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes[J]. J Clin Endocrinol Metab, 2004,89:3543-3553.
[8] Anders J. Serum levels of insulin-like growth factor I and its binding proteins in health and disease[J]. Growth Hormone & IGF Research, 2003,13:113-170.
[9] Low LC, Tam SY, Kwan EY, et al. Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life[J]. Pediatr Res, 2001,50(6):737-742.
[10] Qin LQ, He K, Xu JY. Milk consumption and circulating insulin-like growth factor-I level: a systematic literature review[J]. Int J Food Sci Nutr, 2009,60 (S7):330-340.
[11] Allen NE, Appleby PN, Davey GK, et al. Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men[J]. Br J Cancer, 2000,83 (1):95-97.
[12] Ong K, Langkamp M, Ranke MB, et al. Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study[J]. Am J Clin Nutr, 2009,90:156-161.
