Significance of bone age inspection in children with hypothyroidism
- YAN Xiao-li, WANG Zhi-hua, LI Xiao-qing, PAN Qiu-hong
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Abstract
【Objective】 To observe the bone age development in children with hypothyroidism and explore the potential applications in diagnosis and therapy of hypothyroidism. 【Method】 It was observed that 37 children's X-ray films of left hands and wrists and applied method for assessing bone age of Chinese children to score their bone age. 【Result】 The bone age of children with hypothyroidism were younger than their chronological age and the bone age caughted up the chronological age after treatment in the followed 2~3 years. 【Conclusion】 Bone age inspection has important instructional significance in diagnosis and treatment of hypothyroidism in children.
Key words
bone age / hypothyroidism / method for assessing bone age / thyroid hormone
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References
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[3] 颜纯,王慕迪.小儿内分泌学[M].北京: 人民卫生出版社,2006:155-192.
[4] 程华,段晓岷,孙国强,等.儿童骨龄测定的临床应用价值[J].中国全科医学,2009,12(5):46-47.
[5] 迟素敏. 内分泌生理学[M].西安:第四军医大学出版社,2006:170-176.
[6] Bassett JH, Willams GR. The molecular actions of thyroid hormone in bone[J]. Trends Endocrinol Wetab,2003,14(8):356-364.
[7] Huang BK, Goloen LA, Tarjan G, et al. Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts [J]. Bone Miner Res, 2000, 15 (2):188-197.
[8] Adachi M, Asakura Y, Tachibana K. Final height and pubertal growth in Japanese patients with congenital hypothyroidism detected by neonatal screening[J]. Acta Paediatr, 2003,92(6):698-703.
