Relationship between thyroid function and iron overload in children with β-thalassemia major

DUAN Li; LI Tong; WANG Feng

doi:10.11852/zgetbjzz2019-0844

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (1) : 86-88. DOI: 10.11852/zgetbjzz2019-0844

Relationship between thyroid function and iron overload in children with β-thalassemia major

DUAN Li, LI Tong, WANG Feng

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Abstract

Objective To study the relationship between thyroid function and iron overload in children with β-thalassemia major(β-TM) and to improve the thyroid function. Methods From January to December 2018,44 children with β-TM were treated in Zhuhai Municipal Maternity and Child Health Care Hospital.Their free T3(FT3), free T4(FT4), thyrotropin(TSH) and serum ferritin(SF) were detected by chemiluminescence.The incidence of hypothyroidism in children was investigated and the relationship between SF and TSH was analyzed. Results Among 44 children with β-TM, there were 0 case of hypothyroidism and 6 cases of subclinical hypothyroidism(13.6%).There was a positive correlation between SF and TSH(r=0.399,P＜0.05).The level of SF [(5 933.00±2 405.41)μg/L]in subclinical hypothyroidism children was significantly increased(t=-3.174,P＜0.05).In irregular iron removal group,there were higher levels of SF,TSH[(5 322.50±1 956.37)μg/L,(9.95±9.27)mU/ml] and incidence of subclinical hypothyroidism(33.3%)(t=6.186,2.678,χ²=8.273,P<0.05). Conclusions Thyroid function in children with β-TM is related to SF and irregular iron removal.It is necessary to regulate iron removal to prevent thyroid dysfunction.

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β-thalassemia major / children / hypothyroidism / iron overload

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DUAN Li, LI Tong, WANG Feng. Relationship between thyroid function and iron overload in children with β-thalassemia major[J]. Chinese Journal of Child Health Care. 2020, 28(1): 86-88 https://doi.org/10.11852/zgetbjzz2019-0844

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