Study on the correlation of preterm birth with subclinical hypothyroidism and age of pregnant women

SHAO Ya-wen; BAI Yan; LIN Ru; CHEN Ma-li; HE Wen-hua; ZHAO You-hong

doi:10.11852/zgetbjzz2019-01771

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (3) : 247-251. DOI: 10.11852/zgetbjzz2019-01771

Study on the correlation of preterm birth with subclinical hypothyroidism and age of pregnant women

SHAO Ya-wen, BAI Yan, LIN Ru, CHEN Ma-li, HE Wen-hua, ZHAO You-hong

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Abstract

Objective To investigate the association of preterm birth with pregnant women age and subclinical hypothyroidism (SCH), in order to provide scientific evidence for making individualized strategies for pregnant women with SCH. Methods A total of 2 868 pregnant women in Gansu Provincial Maternity and Child Care Hospital were enrolled in this study from February 2016 and June 2018. Unconditional Logistic regression model was used to evaluate the associations between age, SCH and the risk of preterm birth. Results Compared with moderate age women, women of advanced reproductive age had higher risk of preterm birth (OR=1.67,95%CI: 1.32-2.13). Younger women had higher risk for very preterm birth (OR=3.65, 95%CI: 2.21-6.05).Compared with women with normal thyroid function, women with SCH had higher risk of preterm birth and moderate preterm birth (preterm birth,OR=3.07, 95%CI:2.28-4.12; moderate preterm birth OR=2.67, 95%CI:1.86-3.83).Interaction analysis revealed a multiplier interaction between age and SCH on the risk of preterm birth. Conclusions The risk of preterm birth and its subtypes in SCH patients of different ages is not consistent. It is suggested to assess preterm risk in SCH women by different age groups and take individualized pregnancy management and medication guidance.

Key words

subclinical hypothyroidism / thyroid peroxidase antibody / preterm birth / women of advanced reproductive age

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SHAO Ya-wen, BAI Yan, LIN Ru, CHEN Ma-li, HE Wen-hua, ZHAO You-hong. Study on the correlation of preterm birth with subclinical hypothyroidism and age of pregnant women[J]. Chinese Journal of Child Health Care. 2020, 28(3): 247-251 https://doi.org/10.11852/zgetbjzz2019-01771

References

[1] Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth[J]. N Engl J Med, 2008, 359(3): 262-273.
[2] Rm S, Dw B. Cervical pessary to prevent preterm birth[J]. JAMA, 2017, 318(23): 2299-2300.
[3] Liu L,Johnson HL,Cousens S,et al. Global, regional, and national causes of child mortality: an updated systematic analysisi for 2010 with time trends since 2000[J]. Lancet, 2012, 379(9832): 2151-2161.
[4] 莫莺健, 王长智. 早产相关因素研究进展[J]. 汕头大学医学院学报, 2017, 30(1): 62-64.
[5] Negro R, Mestman JH. Thyroid disease in pregnancy[J].Best Pract Res Clin Endocrinol Metab, 2011, 25: 927-943.
[6] Blazer S, Moreh-Waterman Y, Miller-Lotan R,et al. Maternal hypothyroidismmay affect fetal growth and thyroid function[J]. Obstel Gynecol, 2003, 102(2): 232-241.
[7] 尹玲凤, 丁虹娟. 早产相关因素的临床分析[J]. 中国妇幼健康研究, 2016, 27(10): 1234-1237.
[8] Casey BM, Dashe JS, Wells CE,et al. Subclinical hypothyroidism and pregnancy outcomes[J]. Obstel Gynecol, 2005, 105(2): 239-245.
[9] 王红琴. 妊娠合并甲状腺功能减退的筛查及转归[J]. 中国妇幼保健, 2015, 30(16): 2511-2513.
[10] Green AS, Abalovich M, Alexander E, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum[J]. Thyroid, 2011, 21(10): 1081-1125.
[11] Howson CP, Kinney MV, McDougall L. Born too soon: preterm birth matters[J]. Repord Health, 2013, 10(Suppl 1): S1.
[12] Xu H, Dai Q, Xu Y, et al. Time trends and risk factor associated with premature birth and infants deaths due to prematurity in Hubei Province, China from 2001 to 2012[J]. BMC Pregnancy Childbirth, 2015, 15:329.
[13] Mwaniki MK, Atieno M, Lawn JE, et al. Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic reveiw[J]. Lancet, 2012, 379(9814): 445-452.
[14] Newnham JP, Dickinson JE, Hart RJ, et al. Strategies to prevent preterm birth[J]. Front Immunol, 2014, 5:584.
[15] Abalovich M, Gutierrez S, Alcaraz G, et al. Overt and subclinical hypothyroidism complicating pregnancy[J]. Thyroid, 2002, 12(1):63-68.
[16] Casey BM, Dashe JS, Wells CE,et al. Subclinical hypothyroidism and pregnnacy outcomes[J]. Obstet Gynecol, 2005, 105(2): 239-245.
[17] Schneuer FJ, Nassar N, Tasevski V, et al. Association and predcitve accuracy of high TSH serum levels in first trimester and advese pregnnacy outcomes[J]. J Clin Endocrinol Metab, 2012, 97(9): 3115-3122.
[18] Tong Z, Xiaowen Z, Baomin C, et al. The effect of subclinical maternal thyroid dysfunction and autommunity on intrauterine growth restriction[J]. Medicine (Baltimore), 2016, 95(19): e3677.
[19] Brits H, Adriaanse M, Rall DM, et al. Causes of prematuirty in the bloemfontein academic complex[J]. S Afr Fam Pract, 2015, 58(3): 223-226.
[20] Oakley L, Penn N, Pipi M, et al. Risk of adverse obstetic and neonatal outcomes by maternal age:quantifying individual and population level risk using routine UK maternity data[J]. PLoS One, 2016, 11(10): e0164462.
[21] Barber KJ, Franklyn JA, McCabe CJ,et al. The in virto effects of triiodothyronine on epidermal growth foctor-induced trophoblast function[J]. J Clin Endocrinol Metab, 2005, 90(3): 1655-1661.