Abstract: 【Objective】 To observe changes of microcirculation and blood coagulation when blood pressure in dangerously ill newborn was high and to provide evidence for treatment. 【Methods】 30 newborn children with high blood pressure were chosen, 30 cases were control group. External ear microcirculation in neonates by WX-10C microcirculation microscope, Determination of Serum prothrombin time (PT), Thrombin time (TT), Activated partial thromboplastin time (APTT), Fibrinogen were observed and compared the results between the two groups. 【Results】 The accumulated points about shape of microvessel and blood flow of microcirculation were increased. Discrepancy was significant (P<0.05). Serum prothrombin time (PT), Thrombin time (TT), Activated partial thromboplastin time (APTT) in group of high blood pressure were decline, Fibrinogen was increased (P<0.05). 【Conclusions】 There are disfunction of microcirculation and blood coagulation when blood pressure is high in dangerously ill newborn. Dealing with these disfunction at the same time is necessary while to treat primary disease and reduce blood pressure.

Key words: blood pressure increasing, microcirculation, disfunction of blood coagulation, newborn

摘要： 【目的】 观察危重患儿在血压增高时微循环和凝血功能的变化,为治疗提供依据。 【方法】 抽取本院住院危重新生儿血压增高的患儿30例,血压不波动的患儿为对照组30例,采用WX-10C微循环显微镜观察新生儿耳廓微循环,采血测定凝血酶原时间(PT),凝血酶时间(TT),部分活化凝血活酶时间(APTT),纤维蛋白原(Fib),对结果进行两组比较。 【结果】 血压增高组管袢形态、血流状态积分均高于对照组,差异有统计学意义(P<0.05);血压增高组的PT、APTT和TT下降,Fib增高,差异有统计学意义(P<0.05)。 【结论】 危重新生儿在血压增高时往往伴随着微循环和凝血功能障碍,在治疗原发病及降血压的同时需兼顾到微循环障碍和凝血功能障碍。

关键词: 血压增高, 微循环, 凝血功能障碍, 新生儿