Abstract: 【Objective】 To explore the correlation between contents of α-LNA、DHA、AA and LA in human milk and the development of food allergy in infants. 【Methods】 Cross-sectional study was conducted; breastfed infants aged 3~6 months were enrolled as well as their mothers; human milk samples were collected in the out-patient clinic, contents of PUFAs in human milk were analysed with HPLC method. Infants were diagnosed as food allergy according to R.Sporik's method in our out-patient clinic. 【Results】 10 infants were diagnosed as food allergy, and 21 normal as control. Contents of α-LNA、AA and LA in human milk of food-allergy group were higher than those in control group(P<0.05), except the contents of DHA. 【Conclusions】 The results suggest that human milk rich in n-6 PUFA such as LA and AA may be a risk factor to the development of food allergy in infants.

Key words: maternal milk, polyunsaturated fatty acid, food allergy, infant

摘要： 【目的】 研究人乳多不饱和脂肪酸(polyunsaturated fatty acid, PUFA)含量与婴儿发生食物过敏的关系。 【方法】 采集3~6月人乳喂养婴儿母亲的乳汁,高效液相色谱法法检测其中α-LNA、DHA(n-3组)和LA、AA含量(n-6组);按R.Sporik标准确立婴儿食物过敏,比较食物过敏与正常婴儿母亲乳汁中PUFA含量的差异性。 【结果】 31例3~6月龄人乳喂养婴儿中10例发生食物过敏,过敏婴儿母亲乳汁中LA、AA及α-LNA含量增高(P<0.05)、DHA含量差异无统计学意义。 【结论】 食物过敏婴儿的母亲乳汁中α-LNA、LA、AA含量升高,提示人乳PUFA代谢异常可能与婴儿发生食物过敏有关。

关键词: 人乳, 多不饱和脂肪酸, 食物过敏, 婴儿