Research progress in the neurodevelopment of preterm infants with bronchopulmonary dysplasia

doi:10.11852/zgetbjzz2022-0496

Abstract

Abstract: Bronchopulmonary dysplasia (BPD) is an inflammatory disease caused by dysplasia of the lungs, and is closely related to long-term neurological dysplasia. Premature infants with BPD have developmental impairments in motor, cognitive, neurosensory and behavioral areas, but the mechanism by which BPD causes neurodevelopmental dysplasia in preterm infants remains unclear. This article reviews the effect of BPD on the neurodevelopment of preterm infants and its potential mechanism, including hyperoxia exposure, inflammation, glucocorticoids and nutrition, in order to provide reference for the new respiratory support technology and related neurodevelopment treatment of BPD.

Key words: bronchopulmonary dysplasia, neurodevelopment, preterm infants

摘要： 支气管肺发育不良(BPD)是一种由肺发育不良引起的炎症性疾病,并与远期神经发育不良密切相关。BPD早产儿在运动、认知、神经感觉和行为等方面也存在发育障碍,但BPD引起早产儿神经发育不良的机制尚不明确。本文就BPD对早产儿神经发育的影响及潜在机制,包括高氧暴露、炎症、糖皮质激素、营养等进行综述,以期为BPD新型呼吸支持技术及相关神经发育障碍治疗提供参考。

关键词: 支气管肺发育不良, 神经发育, 早产儿

CLC Number:

R722.6

XIA Zhenglong, SONG Yanyan. Research progress in the neurodevelopment of preterm infants with bronchopulmonary dysplasia[J]. Chinese Journal of Child Health Care, 2023, 31(4): 390-394.

夏正龙, 宋燕燕. 支气管肺发育不良早产儿神经发育研究[J]. 中国儿童保健杂志, 2023, 31(4): 390-394.

References

[1] El-Saie A, Shivanna B. Novel strategies to reduce pulmonary hypertension in infants with bronchopulmonary dysplasia[J]. Front Pediatr, 2020(8):201.
[2] Lui K, Lee SK, Kusuda S, et al. Trends inoutcomes for neonates born very preterm and very low birth weight in 11 high-income countries[J]. J Pediatr, 2019(215):32-40.
[3] Lapcharoensap W, Bennett MV, Xu X, et al. Hospitalization costs associated with bronchopulmonary dysplasia in the first year of life[J]. J Perinatol, 2020,40(1):130-137.
[4] Cheong JLY, Doyle LW. An update on pulmonary and neurodevelopmental outcomes of bronchopulmonary dysplasia[J]. Semin Perinatol, 2018,42(7):478-484.
[5] Homan TD, Nayak RP. Short- and long-term complications of bronchopulmonary dysplasia[J]. Respir Care, 2021,66(10):1618-1629.
[6] Lee JM, Choi YH, Hong J, et al. Bronchopulmonary dysplasia is associated with altered brain volumes and white matter microstructure in preterm infants[J]. Neonatology, 2019,116(2):163-170.
[7] DeMauro SB. Neurodevelopmental outcomes of infants with bronchopulmonary dysplasia[J]. Pediatr Pulmonol, 2021,56(11):3509-3517.
[8] Hintz SR, Kendrick D, Vohr BR, et al. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993—1999[J]. Pediatrics, 2005,115(6):1645.
[9] Gou X, Yang L, Pan L, et al. Association between bronchopulmonary dysplasia and cerebral palsy in children:A meta-analysis[J]. BMJ Open, 2018,8(9):e020735.
[10] DeMauro SB. Theimpact of bronchopulmonary dysplasia on childhood outcomes[J]. Clin Perinatol, 2018,45(3):439-452.
[11] Majnemer A, Riley P, Shevell M, et al. Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors[J]. Dev Med Child Neurol,2000,42(1):53-60.
[12] Drummond D, Hadchouel A, Torchin H, et al. Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm[J]. PLoS One, 2019,14(9):e0222286.
[13] Sriram S, Schreiber MD, Msall ME, et al. Cognitivedevelopment and quality of life associated with BPD in 10-year-olds born preterm[J]. Pediatrics, 2018,141(6):e20172719.
[14] Newman JB, DeBastos AG, Batton D, et al. Neonatal respiratory dysfunction and neuropsychological performance at the preschool age:A study of very preterm infants with bronchopulmonary dysplasia[J]. Neuropsychology, 2011,25(5):666-678.
[15] Brumbaugh JE, Colaizy TT, Patel NM, et al. The changing relationship between bronchopulmonary dysplasia and cognition in very preterm infants[J]. Acta Paediatr, 2018,107(8):1339-1344.
[16] Natarajan G, Pappas A, Shankaran S, et al. Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia:Impact of the physiologic definition[J]. Early Hum Dev, 2012,88(7):509-515.
[17] Lewis BA, Singer LT, Fulton S, et al. Speech and language outcomes of children with bronchopulmonary dysplasia[J]. J Commun Disord, 2002,35(5):393-406.
[18] Perlman JM, Volpe JJ. Movement disorder of premature infants with severe bronchopulmonary dysplasia:A new syndrome[J]. Pediatrics, 1989,84(2):215-218.
[19] Bregman J, Farrell EE. Neurodevelopmental outcome in infants with bronchopulmonary dysplasia[J]. Clin Perinatol, 1992,19(3):673-694.
[20] Lifschitz MH, Seilheimer DK, Wilson GS, et al. Neurodevelopmental status of low birth weight infants with bronchopulmonary dysplasia requiring prolonged oxygen supplementation[J].J Perinatol, 1987,7(2):127-132.
[21] Ari-Even Roth D, Hildesheimer M, Maayan-Metzger A, et al. Low prevalence of hearing impairment among very low birthweight infants as detected by universal neonatal hearing screening[J]. Arch Dis Child Fetal Neonatal Ed, 2006, 91(4):257-262.
[22] Zanchetta S, Resende LA, Bentlin MR, et al. Conductive hearing loss in children with bronchopulmonary dysplasia:A longitudinal follow-up study in children aged between 6 and 24 months[J]. Early Hum Dev, 2010,86(6):385-389.
[23] Gray PH, Sarkar S, Young J, et al. Conductive hearing loss in preterm infants with bronchopulmonary dysplasia[J]. J Paediatr Child Health, 2001,37(3):278-282.
[24] Poon AW,Ma EX, Vadivel A, et al. Impact of bronchopulmonary dysplasia on brain and retina[J]. Biol Open, 2016,5(4):475-483.
[25] Gallini F, Coppola M, De Rose DU, et al. Neurodevelopmental outcomes in very preterm infants:The role of severity of bronchopulmonary dysplasia[J].Early Hum Dev, 2021(152):105275.
[26] Short EJ, Kirchner HL, Asaad GR, et al. Developmental sequelae in preterm infants having a diagnosis of bronchopulmonary dysplasia:Analysis using a severity-based classification system[J].Arch Pediatr Adolesc Med, 2007,161(11):1082-1087.
[27] Brumbaugh JE, Bell EF, Grey SF, et al. Behaviorprofiles at 2 years for children born extremely preterm with bronchopulmonary dysplasia[J]. J Pediatr, 2020(219):152-159.
[28] Rescorla LA, Winder-Patel BM, Paterson SJ, et al. Autism spectrum disorder screening with the CBCL/11/2-5:Findings for young children at high risk for autism spectrum disorder[J].Autism, 2019, 23(1):29-38.
[29] Ratner V, Kishkurno SV, Slinko SK, et al. The contribution of intermittent hypoxemia to lateneurological handicap in mice with hyperoxia-induced lung injury[J]. Neonatology, 2007,92(1):50-58.
[30] Rantakari K, Rinta-Koski OP, Metsaranta M, et al. Early oxygen levels contribute to brain injury in extremely preterm infants[J]. Pediatr Res, 2021,90(1):131-139.
[31] Obst S, Herz J, Alejandre Alcazar MA, et al. Perinatalhyperoxia and developmental consequences on the lung-brain axis[J]. Oxid Med Cell Longev, 2022(2022):5784146.
[32] Dettman RW, Dizon MLV. How lung injury and therapeutic oxygen could alter white matter development[J]. J Neurosci Res,2022,100(12):2127-2137.
[33] Chang JL, Bashir M, Santiago C, et al. Intrauterine growth restriction and hyperoxia as a cause of white matter injury[J]. Dev Neurosci, 2018,40(4):344-357.
[34] Savani RC. Modulators of inflammation inbronchopulmonary dysplasia[J]. Semin Perinatol, 2018,42(7):459-470.
[35] Pcpa B, Jjp B, Tjm A. Bronchopulmonary dysplasia:Pathophysiology and potential anti-inflammatory therapies[J]. Paediatr Respir Rev, 2019(27):34-41.
[36] Dubner SE, Dodson CK, Marchman VA, et al. White matter microstructure and cognitive outcomes in relation to neonatal inflammation in 6-year-old children born preterm[J]. Neuroimage Clin, 2019(23):101832.
[37] Schmitz T, Krabbe G, Weikert G, et al. Minocycline protects the immature white matter against hyperoxia[J]. Exp Neurol, 2014(254):153-165.
[38] Gao S, Zhang X, Du W, et al. Systematic review and meta-analysis:The effect of bronchopulmonary dysplasia on neurodevelopment in very low birth weight premature infants[J]. Transl Pediatr, 2021,10(11):3023-3033.
[39] Buchiboyina AK, Yip CSA, Kohan R, et al. Effect of cumulative dexamethasone dose in preterm infants on neurodevelopmental and growth outcomes:A Western Australia experience[J]. Arch Dis Child Fetal Neonatal Ed, 2021,106(1):69-75.
[40] Georgieff MK, Ramel SE, Cusick SE. Nutritional influences on brain development[J]. Acta Paediatr, 2018,107(8):1310-1321.
[41] Skinner AM, Narchi H. Preterm nutrition and neurodevelopmental outcomes[J]. World J Methodol, 2021,11(6):278-293.
[42] Coviello C, Keunen K, Kersbergen KJ, et al. Effects of early nutrition and growth on brain volumes, white matter microstructure and neurodevelopmental outcome in preterm newborns[J].Pediatr Res, 2018, 83(1-1):102-110.
[43] Bauer SE, Vanderpool CPB, Ren C, et al. Nutrition and growth in infants with established bronchopulmonary dysplasia[J]. Pediatr Pulmonol, 2021,56(11):3557-3562.