Abstract: Objective To study cerebral regional oxygen saturation monitoring on valuing brain function of infants with brain damage syndrome (BDS). Methods A total of 30 infants with BDS were divided into 2 month age group, 3 month age group and 4 month age group, 24 normal infants were adopted as contrast according to age.Using near infrared spectroscopy (NIRS), the changes of cerebral regional oxygen saturation were inspected before and after auditory stimulating in all infants.Using Children's Developmental Center of China(CDCC) scale, the development of neuropsychological was valuated in infants with BDS.Using group t-test, the changes of cerebral regional oxygen saturation were compared between groups and the correlation were compared between the changes of cerebral regional oxygen saturation and mental development index (MDI) using correlation analysis. Results The changes of cerebral regional oxygen saturatio were all lower in BDS group than that in control group, and the changes of cerebral regional oxygen saturatio of normal infants were all higher in 4-month-age group than those in 3-month-age group and 2-month-age group.There were obvious correlations between the changes of cerebral regional oxygen saturatio and MDI of infants. Conclusion Monitoring the changes of cerebral regional oxygen saturation may value brain function of infants with brain damage syndrome.

Key words: cerebral regional oxygen saturation monitoring, infants with brain damage syndrome, brain function, value

摘要： 目的 探讨脑氧饱和度rSO₂的检测对脑损伤综合征婴儿脑功能的评价作用。方法 将30名脑损伤综合征婴儿按年龄分为2月龄、3月龄、4月龄组, 并选取同年龄的正常婴儿作为对照组, 用近红外光谱技术检测每组婴儿oddball范式声音刺激前和刺激过程中反映脑氧合的氧饱和度rSO₂的变化量, 应用婴幼儿智能测查量表测查脑损伤综合征婴儿组神经心理发育;用成组t检验比较各组的脑氧饱和度的变化量, 用相关性分析分析脑损伤婴儿组脑氧饱和度的变化量和神经心理测量量表智能指数(MDI)的相关性。结果 2、3、4月龄组的脑损伤综合征婴儿脑氧饱和度的变化量小于同年龄组的正常婴儿的脑氧饱和度的变化量;4月龄组的正常婴儿的脑氧饱和度的变化量大于3月龄组以及2月龄组正常婴儿的脑氧饱和度的变化量(P<0.05);脑损伤综合征婴儿组的脑氧饱和度的变化量与婴幼儿智能测查量表智能指数有显著性相关(P<0.05)。结论 脑氧饱和度的检测可以作为有脑损伤婴儿脑功能的一种评定方法 。

关键词: 脑氧饱和度检测, 脑损伤综合征婴儿, 脑功能, 评定