儿童过敏性疾病并发抽动障碍机制的研究进展

doi:10.11852/zgetbjzz2023-1327

摘要/Abstract

摘要： 在过去的几十年中,儿童过敏性疾病在全球范围内的发病率逐年升高,其对患儿的影响已经超出了过敏本身。有证据表明儿童过敏性疾病与抽动障碍的发生发展具有相关性。并且过敏性疾病可能是抽动障碍的重要危险因素。其发生机制可能与肠道微生态紊乱、免疫学特征改变以及DNA甲基化相关。深入探讨儿童过敏性疾病和抽动障碍之间的关系,将对预防和治疗抽动障碍具有重要意义。

关键词: 过敏性疾病, 抽动障碍, 肠道微生态, 免疫学特征, DNA甲基化, 儿童

Abstract: In the past few decades,the incidence rate of children's allergic diseases in the world has been gradually increasing worldwide,and its impact on children has exceeded the condition of allergy itself.There is evidence suggesting a correlation between allergic diseases and the different of tic disorder (TD) in children,and allergies may be an important risk factor of TD.The underlying mechanism may be related to intestinal microbiota disorders,changes in immunological characteristics,and DNA methylation.Further exploration of the relationship between allergic diseases and TD will be of great significance for the prevention and treatment of TD.

Key words: allergic diseases, tic disorder, intestinal microbiota, immunological characteristics, DNA methylation, children

中图分类号:

张盼盼, 曹凡, 肖绪武. 儿童过敏性疾病并发抽动障碍机制的研究进展[J]. 中国儿童保健杂志, 2024, 32(12): 1333-1338.

ZHANG Panpan, CAO Fan, XIAO Xuwu. Advances in the possible mechanisms of tic disorders comorbid with allergic diseases in children[J]. Chinese Journal of Child Health Care, 2024, 32(12): 1333-1338.

参考文献

[1] Shin YH,Hwang J,Kwon R,et al.Global,regional,and national burden of allergic disorders and their risk factors in 204 countries and territories,from 1990 to 2019: A systematic analysis for the global burden of disease study 2019[J].Allergy,2023,78(8):2232-2254.
[2] Tian J,Zhang D,Yang Y,et al.Global epidemiology of atopic dermatitis: A comprehensive systematic analysis and modelling study[J].Br J Dermatol,2023,190(1):55-61.
[3] Sultész M,Horváth A,Molnár D,et al.Prevalence of allergic rhinitis,related comorbidities and risk factors in school children[J].Allergy Asthma Clin Immunol,2020,16(1):98.
[4] Mazur M,Czarnobilska M,Dyga W,et al.Trends in the epidemiology of allergic diseases of the airways in children growing up in an urban agglomeration[J].Clin Med,2022,11(8):2188.
[5] Jafari F,Abbasi P,Rahmati M,et al.Systematic review and meta-analysis of tourette syndrome prevalence;1986 to 2022[J].Pediatr Neurol,2022(137):6-16.
[6] Li F,Cui Y,Li Y,et al.Prevalence of mental disorders in school children and adolescents in China: Diagnostic data from detailed clinical assessments of 17,524 individuals[J].Child Psychol Psychiatry,2022,63(1):34-46.
[7] Liu Y,Li Y,Ma X,et al.Comparative analysis of serum total IgE levels and specific IgE levels in children aged 6 to 9 years with tic disorder and normal children[J].BMC Pediatr,2023,23(1):399.
[8] Finegold I.Allergy and Tourette's syndrome[J].Annals of Allergy,1985,55(2):119-121.
[9] Kim H,Moote W,Mazza J.Tourette's syndrome in patients referred for allergy evaluation[J].Ann Allergy Asthma Immunol,1997,79(4):347-349.
[10] Ho CS,Shen EY,Shyur SD,et al.Association of allergy with Tourette's syndrome[J].Formos Med Assoc,1999,98(7):492-495.
[11] Huang J,Li R,Li L,et al.The relationship between allergic diseases and tic disorders: A systematic review and meta-analysis[J].Neurosci Biobehav Rev,2022(132): 362-377.
[12] Chang YT,Li YF,Muo CH,et al.Correlation of Tourette syndrome and allergic disease: Nationwide population-based case-control study[J].Dev Behav Pediatr,2011,32(2):98-102.
[13] Yuce M,Guner SN,Karabekiroglu K,et al.Association of Tourette syndrome and obsessive-compulsive disorder with allergic diseases in children and adolescents: A preliminary study[J].Eur Rev Med Pharmacol Sci,2014,18(3):303-310.
[14] Chen L,Chen X,Ke N,et al.Association between allergic conjunctivitis and provisional tic disorder in children[J].Int Ophthalmol,2020,40(1):247-253.
[15] Liu X,Wang X,Zhang X,et al.Allergic diseases influence symptom severity and T lymphocyte subgroups of children with tic disorders[J].Investig Med,2021,69(8):1453-1457.
[16] 张情梅,许白叶,王清海,等.儿童抽动障碍与变态反应性疾病相关性研究[J].医学研究杂志,2022,51(7):72-75.
Zhang QM,Xu BY,Wang QM,et al.Research on the relationship between tic disorder and allergic diseases in children[J].Journal of Medical Research,2022,51(7):72-75.(in Chinese)
[17] 常莹,李敏,李发军,等.儿童抽动障碍与过敏性疾病的相关性研究[J].中国临床医生杂志,2022,50(5):610-613.
Chang Y,Li M,Li FJ,et al.Research on the correlation between childhood tic disorders and allergic diseases[J].Chinese Journal for Clinicians,2022,50(5):610-613.(in Chinese)
[18] Hu C,van Meel ER,Medina-Gomez C,et al.A population-based study on associations of stool microbiota with atopic diseases in school-age children[J].Allergy Clin Immunol,2021,148 (2):612-620.
[19] Zhang P,Zhou X,Tan H,et al.Microbial signature of intestine in children with allergic rhinitis[J].Front Microbiol,2023(14):1208816.
[20] Songjinda P,Nakayama J,Tateyama A,et al.Differences in developing intestinal microbiota between allergic and non-allergic infants: A pilot study in Japan[J].Biosci Biotechnol Biochem,2007,71(9):2338-2342.
[21] Arrieta MC,Arévalo A,Stiemsma L,et al.Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting[J].Allergy Clin Immunol,2018,142(2):424-434.e10.
[22] Cait A,Hughes MR,Antignano F,et al.Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids[J].Mucosal Immunol,2018,11(3):785-795.
[23] Roduit C,Frei R,Ferstl R,et al.High levels of butyrate and propionate in early life are associated with protection against atopy[J].Allergy,2019,74(4):799-809.
[24] Rauf A,Khalil AA,Rahman UU,et al.Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review[J].Crit Rev Food Sci Nutr,2022,62(22):6034-6054.
[25] Dicks LMT.Gut bacteria and neurotransmitters[J].Microorganisms,2022,10(9):1838.
[26] Vicentini FA,Keenan CM,Wallace LE,et al.Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia[J].Microbiome,2021,9(1):210.
[27] Claudino Dos Santos JC,Lima MPP,Brito GAC,et al. Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis[J].Ageing Res Rev,2023,84:101812.
[28] Block ML,Zecca L,Hong JS.Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms[J].Nat Rev Neurosci,2007,8(1):57-69.
[29] Erny D,Hrabě de Angelis AL,Jaitin D,et al.Host microbiota constantly control maturation and function of microglia in the CNS[J].Nat Neurosci,2015,18(7):965-977.
[30] Patnala R,Arumugam TV,Gupta N,et al.HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke[J].Mol Neurobiol,2017,54(8):6391-6411.
[31] Collison LW,Workman CJ,Kuo TT,et al.The inhibitory cytokine IL-35 contributes to regulatory T-cell function[J].Nature,2007,450(7169):566-569.
[32] Kumar A,Williams MT,Chugani HT.Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and tourette syndrome:A positron emission tomographic (PET) study using 11C-[R]-PK11195[J].Child Neurol,2015,30(6):749-756.
[33] Frick L,Pittenger C.Microglial dysregulation in OCD,Tourette syndrome,and PANDAS[J].Immunol Res,2016,2016:8606057.
[34] Cheng YH,Zheng Y,He F,et al.Detection of autoantibodies and increased concentrations of interleukins in plasma from patients with Tourette's syndrome[J].Mol Neurosci,2012,48 (1): 219-224.
[35] Kawikova I,Leckman JF,Kronig H,et al.Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: A preliminary study[J].Biol Psychiatry,2007,61(3):273-278.
[36] Habib N,Pasha MA,Tang DD.Current understanding of asthma pathogenesis and biomarkers[J].Cells,2022,11(17):2764.
[37] 王星,李瑞婷,马小苗.过敏性哮喘患儿血清lncRNA MEG3表达与Th17/Treg平衡的关系[J].中国医药导报,2023,20(20):113-116.
Wang X,Li RT,Ma XM.Relationship between serum lncRNA MEG3 expression and Th17/Treg balance in children with allergic asthma[J].China Medical Herald,2023,20(20):113-116.(in Chinese)
[38] Joetham A,Schedel M,O'Connor BP,et al.Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways[J].Allergy Clin Immunol,2017,139(4):1331-1342.
[39] Zhao ST,Wang CZ.Regulatory T cells and asthma[J].Zhejiang Univ Sci B,2018,19(9):663-673.
[40] Lechner A,Henkel FDR,Hartung F,et al.Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma[J].Allergy Clin Immunol,2022,149(6):2078-2090.
[41] Lamothe H,Tamouza R,Hartmann A,et al.Immunity and Gilles de la Tourette syndrome: A systematic review and meta-analysis of evidence for immune implications in Tourette syndrome[J].Eur J Neurol,2021,28(9):3187-3200.
[42] Hsu CJ,Wong LC,Lee WT.Immunological dysfunction in Tourette syndrome and related disorders[J].Int J Mol Sci,2021,22(2):853.
[43] Leckman JF,Katsovich L,Kawikova I,et al.Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome[J].Biol Psychiatry,2005,57(6):667-673.
[44] Yeon SM,Lee JH,Kang D,et al.A cytokine study of pediatric Tourette's disorder without obsessive compulsive disorder[J].Psychiatry Res,2017(247):90-96.
[45] Zalcman S,Murray L,Dyck DG,et al.Interleukin-2 and-6 induce behavioral-activating effects in mice[J].Brain Res,1998,811(1-2):111-121.
[46] Smith SE,Li J,Garbett K,et al.Maternal immune activation alters fetal brain development through interleukin-6[J].Neurosci,2007,27(40):10695-10702.
[47] Robertson NP.Advances in Tourette's syndrome[J].Neurol,2023,270(3):1808-1810.
[48] Xu CJ,Söderháll C,Bustamante M,et al.DNA methylation in childhood asthma: An epigenome-wide meta-analysis[J].Lancet Respir Med,2018,6(5):379-388.
[49] Stefanowicz D,Hackett TL,Garmaroudi FS,et al.DNA methylation profiles of airway epithelial cells and PBMCs from healthy,atopic and asthmatic children[J].PLoS One,2012,7(9): e44213.
[50] Swamy RS,Reshamwala N,Hunter T,et al.Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy[J].Allergy Clin Immunol,2012,130(1): 215-224.e7.
[51] Bayrak Degirmenci P,Aksun S,Altin Z,et al.Allergic Rhinitis and its relationship with IL-10,IL-17,TGF-β,IFN-γ,IL 22,and IL-35[J].Dis Markers,2018(2018):9131432.
[52] Müller-Vahl KR,Loeber G,Kotsiari A,et al.Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene[J].Psychiatr Res,2017(86):1-8.
[53] Zilhão NR,Padmanabhuni SS,Pagliaroli L,et al.Epigenome-wide association study of tic disorders[J].Twin Res Hum Genet,2015,18(6):699-709.
[54] Forno E,Wang T,Qi C,et al.DNA methylation in nasal epithelium,atopy,and atopic asthma in children: A genome-wide study[J].Lancet Respir Med,2019,7(4):336-346.
[55] Tsetsos F,Yu D,Sul JH,et al.Synaptic processes and immune-related pathways implicated in Tourette syndrome[J].Transl Psychiatry,2021,11(1):56.
[56] Pagliaroli L,Vetö B,Arányi T,et al.From genetics to epigenetics: New perspectives in Tourette syndrome research[J].Front Neurosci,2016(10):277.
[57] Wang W,Cohen JA,Wallrapp A,et al.Age-related dopaminergic innervation augments T helper 2-type allergic inflammation in the postnatal lung[J].Immunity,2019,51(6):1102-1118.e7.