抽动障碍儿童的饮食营养与肠道菌群的研究进展

doi:10.11852/zgetbjzz2023-1384

中国儿童保健杂志 ›› 2024, Vol. 32 ›› Issue (11): 1232-1235.DOI: 10.11852/zgetbjzz2023-1384

抽动障碍儿童的饮食营养与肠道菌群的研究进展

唐雅君, 刘秀梅

福建医科大学妇儿临床医学院,福建省儿童医院(上海儿童医学中心福建医院)发育行为儿科,福建福州 350011

收稿日期:2023-12-29 修回日期:2024-04-26 发布日期:2024-11-04 出版日期:2024-11-10
通讯作者: 刘秀梅,E-mail:xmliu0615@fjmu.edu.cn
作者简介:唐雅君(2000-),女,福建人,在读硕士研究生,主要研究方向为发育行为儿科。
基金资助:
福建省自然科学基金面上项目(2021J01424);福建省医学创新课题项目(2022CXB012);福建省儿童医院科技创新启动基金(YCXZ202203,YCXY202103)

Research progress on dietary nutrition and intestinal flora in children with tic disorder

TANG Yajun, LIU Xiumei

Developmental Behavioral Pediatrics, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian 350011, China

Received:2023-12-29 Revised:2024-04-26 Online:2024-11-10 Published:2024-11-04
Contact: LIU Xiumei, E-mail: xmliu0615@fjmu.edu.cn

摘要/Abstract

摘要： 抽动障碍儿童存在饮食行为及营养问题,导致其膳食营养结构不均衡,并影响其肠道菌群组成。各类营养素及肠道菌群可能通过多种代谢途径或微生物-肠-脑轴参与抽动的发生发展过程,相关补充剂可能有助于缓解抽动症状。本文就抽动障碍儿童的饮食营养、肠道菌群特征及相关干预措施进行综述,并讨论潜在的生物学机制,为临床监测抽动障碍儿童的饮食营养问题及早期干预提供科学依据。

关键词: 抽动障碍, 饮食, 营养, 肠道菌群

Abstract: Children with tic disorder (TD) have dietary behaviors and nutritional problems, which may lead to unbalanced dietary nutrition structure and affect the composition of their gut microbiota. Nutrients and gut microbiota may participate in the occurrence and development of tic through various metabolic pathways or microbial-gut-brain axis. Supplements may help relieve tic symptoms. This article reviews dietary nutrition, gut flora characteristics and related interventions in children with TD, and discusses the underlying biological mechanisms to provide a scientific basis for clinical monitoring of dietary nutritional problems and early intervention in children with TD.

Key words: tic disorder, diet, nutrition, gut microbiota

中图分类号:

R749.94

唐雅君, 刘秀梅. 抽动障碍儿童的饮食营养与肠道菌群的研究进展[J]. 中国儿童保健杂志, 2024, 32(11): 1232-1235.

TANG Yajun, LIU Xiumei. Research progress on dietary nutrition and intestinal flora in children with tic disorder[J]. Chinese Journal of Child Health Care, 2024, 32(11): 1232-1235.

参考文献

[1] Johnson KA, Worbe Y, Foote KD, et al. Tourette syndrome: Clinical features, pathophysiology, and treatment[J]. Lancet Neurol, 2022, 22(2):147-158.
[2] Iverson AM, Black KJ. Why tic severity changes from then to now and from here to there[J]. J Clin Med, 2022, 11(19):5930-5930.
[3] Qi YJ, Zheng Y, Li ZJ, et al. Genetic studies of tic disorders and Tourette syndrome[J].Methods Mol Biol, 2019, 2011:547-571.
[4] Ludlow KA, Rogers LS. Understanding the impact of diet and nutrition on symptoms of Tourette syndrome: A scoping review[J]. J Child Health Care, 2018, 22(1):68-83.
[5] Smith B, Rogers LS, Blissett J, et al. The role of sensory sensitivity in predicting food selectivity and food preferences in children with Tourette syndrome[J]. Appetite, 2019, 135:131-136.
[6] Smith B, Rogers LS, Blissett J, et al. The relationship between sensory sensitivity, food fussiness and food preferences in children with neurodevelopmental disorders[J]. Appetite, 2020, 150: 104643.
[7] Smith BL, Ludlow AK. An exploration of eating behaviours and caregiver mealtime actions of children with Tourette syndrome[J]. Front Pediatr, 2022, 10:933154-933154.
[8] Qian RY, Ma Y, You LQ, et al. The blood levels of trace Elements are lower in children with tic disorder: Results from a retrospective study[J]. Front Neurol, 2019, 10:1324.
[9] Liang H, Sun X, Ma A, et al. Evaluation of dietary behavior and nutrient intake in patients with Tourette Syndrome[J].FASEB J, 2015, 29(S1).
[10] Zickgraf HF, Richard E, Zucker NL, et al. Rigidity and sensory sensitivity: Independent contributions to selective eating in children, adolescents, and young adults[J]. J Clin Child Adolesc Psychol, 2022, 51(5):675-687.
[11] Soler N, Hardwick C, Perkes IE, et al. Sensory dysregulation in tic disorders is associated with executive dysfunction and comorbidities[J]. Mov Disord, 2019, 34(12):1901-1909.
[12] Bamigbade SE, Rogers SL, Wills W, et al. Mothers' accounts of mealtime and feeding challenges for children with Tourette syndrome or persistent tic disorders[J]. Front Psychiatry, 2022, 13:936796.
[13] Sapozhnikov Y, Vermilion J. Co-occurring anxiety in youth with tic disorders: A review[J]. J Child Adolesc Psychopharmacol, 2023, 33(10): 402-408.
[14] Smith BL, Ludlow AK. Patterns of nutritional supplement use in children with Tourette syndrome[J]. J Diet Suppl, 2023, 20(1):28-43.
[15] Ghosh D, Burkman E. Relationship of serum ferritin level and tic severity in children with Tourette syndrome[J]. Childs Nerv Syst, 2017, 33 (8): 1373-1378.
[16] Renata R, Adriana P, Miriam S, et al. Use of nutritional supplements based on L-theanine and vitamin B6 in children with Tourette syndrome, with anxiety disorders: A pilot study[J]. Nutrients, 2022, 14 (4): 852.
[17] Rodrigo L, Álvarez N, Fernández-Bustillo E, et al. Efficacy of a gluten-free diet in the Gilles de la Tourette syndrome: A pilot study[J]. Nutrients, 2018, 10 (5): 573.
[18] Xi WJ, Gao XF, Zhao HJ, et al. Depicting the composition of gut microbiota in children with tic disorders: An exploratory study[J]. J Child Psychol Psychiatry, 2021, 62(10): 1246-1254.
[19] Wang YP, Xu HX, Jing XY, et al. Gut microbiome composition abnormalities determined using high-throughput sequencing in children with tic disorder[J]. Front Pediatr, 2022, 10:831944.
[20] 王艳萍, 井淼, 华颖, 等. 双歧杆菌三联活菌散添加治疗儿童抽动障碍疗效及对血清兴奋性氨基酸水平影响[J]. 实用医学杂志, 2022, 38 (02): 212-216.
Wang YP, Jing M, Hua Y, et al. Clinical efficacy of Bifidobacterium triple viable powder as add-on therapy in children with tic disorder and its effect on the level of excitatory amino acids in serum[J]. J Pract Med, 2022, 38(02):212-216.(in Chinese)
[21] Cheng LH, Liu YW, Wu CC, et al. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders[J] J Food Drug Anal, 2019, 27(3): 632-648.
[22] Liao JF, Chen YF, Li SW, et al. Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota gut-brain-axis[J]. Brain Res Bull, 2019, 153:59-73.
[23] Wu CC, Wong LC, Hsu CJ, et al. Randomized controlled trial of probiotic PS128 in children with Tourette syndrome[J]. Nutrients, 2021, 13(11): 3698.
[24] Gabbay V, Babb JS, Klein RG, et al. A double-blind, placebo-controlled trial of ω-3 fatty acids in Tourette's disorder[J].Pediatrics, 2012, 129(6):e1493-e1500.
[25] Cohen KK, Muhardi L, Parikh P, et al. Nutritional support of neurodevelopment and cognitive function in infants and young children-an update and novel insights[J]. Nutrients, 2021, 13(1): 199.
[26] Jiang YL, Li Y, Chen X, et al. Biomarkers and Tourette syndrome: A systematic review and meta-analysis[J]. Front Neurol, 2024, 15:1262057.
[27] Willekens J, Runnels LW. Impact of Zinc transport mechanisms on embryonic and brain development[J]. Nutrients, 2022, 14(12):2526.
[28] Kanaan AS, Yu D, Metere R, et al. Convergent imaging-transcriptomic evidence for disturbed iron homeostasis in Gilles de la Tourette syndrome[J]. Neurobiol Dis, 2023, 185106252-106252.
[29] Lamanna J, Ferro M, Spadini S, et al. The dysfunctional mechanisms throwing tics: Structural and functional changes in Tourette syndrome[J]. Behav Sci (Basel), 2023, 13(8):668.
[30] Lin XX, Jiang JL, Chen XR, et al. Vitamin D status and tic disorder: A systematic review and meta-analysis of observational studies[J]. Front Pediatr, 2023, 11:1173741.
[31] Cui X, Pertile R, Liu P, et al. Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator[J]. Neuroscience, 2015, 304: 90-100.
[32] Martino D, Johnson I, Leckman JF. What does immunology have to do with normal brain development and the patho physiology underlying Tourette syndrome and related neuropsychiatric disorders?[J]. Front Neurol, 2020, 11:567407.
[33] Mirarchi A, Albi E, Beccari T, et al. Microglia and brain disorders:The role of vitamin D and its receptor[J]. Int J Mol Sci, 2023, 24(15):11892.
[34] Ekstrand B, Scheers N, Rasmussen MK, et al. Brain foods-the role of diet in brain performance and health[J]. Nutr Rev, 2020, 79(6):693-708.
[35] Góralczyk-Bińkowska A, Szmajda-Krygier D, Kozłowska E. The microbiota-gut-brain axis in psychiatric disorders[J]. Int J Mol Sci, 2022, 23(19):11245.
[36] Pascale A, Marchesi N, Govoni S, et al. Targeting the microbiota in pharmacology of psychiatric disorders[J]. Pharmacol Res, 2020, 157: 104856.
[37] Duranti S, Ruiz L, Lugli GA, et al. Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA[J]. Sci Rep, 2020, 10(1):14112.
[38] Puts NA, Harris AD, Crocetti D, et al. Reduced GABAergic inhibition and abnormal sensory symptoms in children with Tourette syndrome[J].J Neurophysiol, 2015, 114(2):808-817.
[39] Socała K, Doboszewska U, Szopa A, et al. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders[J]. Pharmacol Res, 2021, 172:105840.
[40] Wang XM, Liu XM, Chen LL, et al. The inflammatory injury in the striatal microglia-dopaminergic-neuron crosstalk involved in Tourette syndrome development[J]. Front Immunol, 2023, 14:1178113.
[41] Lennington JB, Coppola G, Kataoka-Sasaki Y, et al. Transcriptome anlysis of the human striatum in Tourette syndrome[J]. Biol Psychiatry, 2016, 79(5):372-382.
[42] Mittal R, Debs LH, Patel AP, et al. Neurotransmitters: the critical modulators regulating gut-brain axis[J]. J Cell Physiol, 2017, 232(9): 2359-2372.

抽动障碍儿童的饮食营养与肠道菌群的研究进展

Research progress on dietary nutrition and intestinal flora in children with tic disorder

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	王峤, 巩纯秀. 家族性高乳糜微粒血症饮食治疗与挑战[J]. 中国儿童保健杂志, 2024, 32(9): 934-936.
[2]	吴妍, 刘莎, 高利旺, 李超, 魏炜, 龙宇, 张永红, 殷光玲, 白晶, 赵莉, 王友发. 中国西部脱贫地区小学生体重状态和饮食行为干预效果研究[J]. 中国儿童保健杂志, 2024, 32(9): 958-963.
[3]	夏嘉苓, 官计, 方悦, 黄迎春, 刘颖, 李凡, 吉木尔呷木. 儿童家庭饮食环境的研究进展[J]. 中国儿童保健杂志, 2024, 32(9): 984-988.
[4]	周琼, 刘海波, 胡必梅, 郭玉清. 母亲喂养方式、婴幼儿饮食行为及气质对儿童超重肥胖的影响[J]. 中国儿童保健杂志, 2024, 32(8): 850-855.
[5]	罗光月, 陆韦, 徐德勇, 邱政飞, 李宗龙. 不同喂养方式对牛奶蛋白过敏患儿肠道菌群的影响[J]. 中国儿童保健杂志, 2024, 32(8): 908-913.
[6]	陈丽羽, 胡燕, 张萱. 婴儿期食物多样性在预防食物过敏中的效果及机制[J]. 中国儿童保健杂志, 2024, 32(7): 767-771.
[7]	刘艳, 陈杰, 李新, 陈暕. 青岛市中学生抑郁症状现况及影响因素分析[J]. 中国儿童保健杂志, 2024, 32(7): 790-794.
[8]	陈巧玲, 陆韦. 住院患儿营养风险筛查的研究进展[J]. 中国儿童保健杂志, 2024, 32(6): 653-660.
[9]	李宗芹, 王念蓉, 申量, 肖宵, 王丽. 婴儿体成分与超重/肥胖的一致性分析[J]. 中国儿童保健杂志, 2024, 32(6): 672-677.
[10]	邵洁, 高嘉滢. 营养与生命早期脑发育[J]. 中国儿童保健杂志, 2024, 32(4): 368-371.
[11]	尤奕, 刘方芳, 秦宏宇, 徐腊梅, 景然, 高淑清. 石家庄市正定县青少年近视与营养相关的影响因素研究[J]. 中国儿童保健杂志, 2024, 32(4): 395-400.
[12]	吕丽娜, 朱冰泉. 母乳主要活性成分对婴儿肠道及免疫功能影响的研究进展[J]. 中国儿童保健杂志, 2024, 32(4): 424-428.
[13]	张嘉文, 赵梓伶, 陈诗琪, 周天津, 李彦霖, 刘宇辞, 罗敏. 2012—2022年全球学龄前儿童营养研究热点与趋势可视化分析[J]. 中国儿童保健杂志, 2024, 32(4): 433-439.
[14]	王文娴, 王海宁, 高晶晶, 霍言言, 杨帆, 陈津津. 养育者喂养照护风格与营养问题儿童晚餐质量的相关性[J]. 中国儿童保健杂志, 2024, 32(4): 460-464.
[15]	荫士安, 杨振宇. 我国儿童维生素A和维生素D营养现状及缺乏共病问题[J]. 中国儿童保健杂志, 2024, 32(3): 301-306.