关键词: 脑性瘫痪, 早产儿, 脑损伤, 危险因素, 脑室周围白质软化, 高肌张力

Abstract: Objective To explore the risk factors of cerebral palsy in preterm infants with brain injury and provide clinic data for prevention or improvement the outcome of cerebral palsy and early diagnosis of cerebral palsy correctly in preterm infants with brain injury. Methods Total number of 101 preterm infants under one year of age with brain injury treated in Qingdao Rehabilitation Center for Disabled Children from January 2000 to December 2010 were followed to observe and analyse the risk factors of cerebral palsy with Logistic stepwise regression. Results Among the 101 infants,51(50.50%) were diagnosed of cerebral palsy at the age of 2.Gestational age <32 weeks,birth weight <2 500 g,head circumference <x--s,strabismus,tone level ≥I⁺,ankle clonus,periventricular leukomalacia(PVL)or injury of basal ganglia regions in magnetic resonance imaging(MRI),developmental quotient(DQ) of gross motor at base line <55 and progressive speed <0.75 were risk factors of cerebral palsy in preterm infants with brain injury(P<0.05). Conclusions The existence of small gestational age,low birth weight,small head circumference,strabismus,high tone level,ankle clonus,PVL or injury of basal ganglia regions in MRI,low DQ of gross motor and slow progressive speed can have predictive value of cerebral palsy in preterm infants with brain injury.It is recommended that preterm infants with brain injury should be examined of above-mentioned indicatrix as a routine and be improved as far as possible.An early hypertonia in preterm infants should be decided carefully combining with other conditions.

Key words: cerebral palsy, preterm infants, brain injury, risk factors, periventricular leukomalacia, hypertonia