关键词: 肥胖, 多肽, 神经肽, 胞内肽, 功能研究

Abstract: Peptide is a kind of chemically active agent composed of amino acid connected by peptide bonds.Tens of thousands of peptides have been found in body and possess certain physiological activity.Peptides function as intercellular messengers in the endocrine system and in brain.The functional peptides in obesity and the associated diseases have been widely demonstrated,such as neuropeptide Y,brain-gut peptide and GLP-1.In recent years,the rapid development of peptidomics helps to identify more peptides.Endogenous peptides derived from the noncoding region with a short open reading frame,homology of well-established peptides,fragment of protein molecular and intracellular peptides in adipocytes are also beginning to raise the attention of the researchers.This study aimed at progress and new trend of peptides research,providing new targets for the prevention and treatment of obesity.

Key words: obesity, peptide, neuropeptide, intracellular peptide, function study