多肽是由氨基酸通过肽键相连而成的一类化学活性物质。生物体内已发现的多肽种类达数万种,具有一定生理活性。多肽作为神经-内分泌系统调控的信号分子,在肥胖及相关并发症中的作用得到广泛揭示,如神经肽 Y、脑肠肽、胰高血糖素样肽等。近年,多肽组学的快速发展给多肽研究再添新概念,其中非编码基因短开放阅读框编码、功能肽同源区域、大蛋白分子断裂片段等来源的多肽以及脂肪细胞自身产生的内源性多肽也开始引起研究者的重视。本文就多肽在肥胖中的研究进展和趋势展开综述,为肥胖的预防和治疗提供了新的靶点。
Abstract
Peptide is a kind of chemically active agent composed of amino acid connected by peptide bonds.Tens of thousands of peptides have been found in body and possess certain physiological activity.Peptides function as intercellular messengers in the endocrine system and in brain.The functional peptides in obesity and the associated diseases have been widely demonstrated,such as neuropeptide Y,brain-gut peptide and GLP-1.In recent years,the rapid development of peptidomics helps to identify more peptides.Endogenous peptides derived from the noncoding region with a short open reading frame,homology of well-established peptides,fragment of protein molecular and intracellular peptides in adipocytes are also beginning to raise the attention of the researchers.This study aimed at progress and new trend of peptides research,providing new targets for the prevention and treatment of obesity.
关键词
肥胖 /
多肽 /
神经肽 /
胞内肽 /
功能研究
Key words
obesity /
peptide /
neuropeptide /
intracellular peptide /
function study
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基金
国家973计划项目(2013CB530604);国家自然科学基金(81330067, 81600687,81600665,81670773);南京市卫生科技发展项目(YKK15161)
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