内分泌干扰物对儿童青春期发育的影响

摘要/Abstract

摘要： 青春期启动和进程受到神经内分泌系统的调控,下丘脑-垂体-性腺轴发挥主要作用。全球性人群研究提示青春期发育有提前趋势。这种变化除了与社会经济改变和营养保健的改善有关以外,环境中一些内分泌干扰化学物质(endocrine disrupting chemical,EDCs)对青春期发育的影响受到关注。许多化学物质包括用于农业的杀虫剂、杀真菌剂、除草剂,日常生活使用的清洁物质、化妆产品、塑料物质和溶剂等可能都是EDCs。EDCs通过雌激素、抗雌激素、雄性或抗雄性激素样效应或通过促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)影响儿童青春期发育,表现性早熟、性发育迟缓、生殖器畸形等。

关键词: 环境, 内分泌干扰物, 儿童, 青春期

中图分类号:

R725.8

肖延风. 内分泌干扰物对儿童青春期发育的影响[J]. 中国儿童保健杂志, 2013, 21(3): 230-233.

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