【目的】 观察母亲ɑ1,2岩藻糖基转移酶(type α1,2 fucosyltransferase,FUT2)基因单核苷酸位点多态性(single nucleotide polymorphism,SNP)对母乳喂养儿早期体格生长发育及常见疾病发病率的影响。【方法】 选取110对新生儿及母亲进入课题,产后2周收集母亲唾液用于提取DNA行SNP检测。每周记录小儿喂养及疾病情况至12个月,于小儿4、13、26、52周时行体格测量。【结果】 本组小儿感染性疾病发病率与文献相比明显降低;AT基因型母亲与AA、TT型母亲相比,小儿早期体格生长发育更快,13、26周及52周体重,26周及52周身高,52周头围Z分均较高(P<0.05),且中重度呼吸道感染发病率较低(P<0.05);母亲SNP基因型不同的小儿在12月龄内湿疹发病率差异无统计学意义(P>0.05),双亲均有过敏性疾病史的小儿湿疹发病率高于双亲无过敏史者(P<0.05)。【结论】 母乳喂养有助于降低小儿12月龄内常见感染性疾病发病;AT基因型母亲的母乳更利于小儿早期生长;家族遗传风险会影响小儿湿疹发病率。
Abstract
【Objective】 To examine the association between variation in mother's SNP genotype of FUT2 and infants' early growth and prevalence of common diseases. 【Methods】 110 breastfeeding mother-infant pairs were recruited in this study.Saliva samples were collected at 2 weeks postpartum.Infants' anthropometric indices like weight,height and head circumference were measured at the age of 4,13,26,52 w.The information of infants' sickness and diets were recorded by enquiring mothers by telephone. 【Results】 The incidence of common infectious diseases of this group of children was lower comparing with that published in the literature.Infants whose mothers' SNP genotype were AT grew faster than those whose mothers' SNP genotype were AA or TT.Their Z scores of weight at 13,26,52 w,height at 26,52 w and head circumference at 52 w were higher than those of other two groups (P<0.05),and their incidence of moderate to severe acute respiratory illness was lower (P<0.05);There were no significant differences of infants' incidence of eczema among different SNP genotype mothers' infants (P>0.05).However,the incidence of eczema of infants whose parents had atopic history was higher than whom they hadn't (P<0.05). 【Conclusions】 Breastfeeding could decrease the incidence of infants' common infectious diseases;AT maternal SNP (rs1047781) genotype of FUT2 profits infants more on early growth.Infants' incidence of eczema is associated with family history of hypersensitivity.
关键词
母乳 /
中性寡糖 /
FUT2基因 /
基因多态性 /
生长 /
发病率
Key words
breast milk /
neutral oligosaccharide /
type α1,2 fucosyltransferase gene /
genetic polymorphism /
growth /
incidence
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基金
美国儿童健康与人类发育国立研究所项目( HD13021)
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