运动干预改善孤独症谱系障碍儿童青少年抑制控制功能的研究进展

doi:10.11852/zgetbjzz2024-0037

摘要/Abstract

摘要： 本文旨在综述运动干预对孤独症谱系障碍(ASD)儿童青少年抑制控制功能的影响及其潜在机制,同时系统地回顾了近年来关于运动干预对ASD儿童青少年抑制控制功能影响的实验性研究。研究表明,运动干预能显著改善ASD儿童青少年的抑制控制能力,且运动干预形式呈多样化的趋势,从传统武术到球类运动,以及结合虚拟现实技术的新兴方式。通过运动干预能改善心血管机能、重塑大脑结构、改变脑血流量及增加神经营养因子浓度等途径,促进大脑生理变化,进而提高抑制控制能力。

关键词: 孤独症谱系障碍, 运动干预, 抑制控制, 执行功能, 青少年, 儿童

Abstract: This article aims to explore the effect and potential mechanisms of exercise intervention on the inhibitory control function of children and adolescents with autism spectrum disorder (ASD), and systematically review experimental studies on the effect of exercise intervention on the inhibitory control function of children and adolescents with ASD in recent years. Research has shown that exercise intervention can significantly improve the inhibitory control ability of children and adolescents with ASD, and the forms of exercise intervention are diverse, ranging from traditional martial arts to ball games, as well as emerging methods combining virtual reality technology. Exercise intervention can promote physiological changes in the brain by improving cardiovascular function, reshaping brain structure, altering cerebral blood flow, and increasing neurotrophic factor concentration, thereby enhancing inhibitory control ability.

Key words: autism spectrum disorder, exercise intervention, inhibition, executive function, adolescents, children

中图分类号:

R749.94

侯耀奇, 王燕, 邓佳琪, 宋湘勤. 运动干预改善孤独症谱系障碍儿童青少年抑制控制功能的研究进展[J]. 中国儿童保健杂志, 2025, 33(1): 92-96.

HOU Yaoqi, WANG Yan, DENG Jiaqi, SONG Xiangqin. Research progress on improving inhibitory control function in children andadolescents with autism spectrum disorder through exercise intervention[J]. Chinese Journal of Child Health Care, 2025, 33(1): 92-96.

参考文献

[1] Diamond A. Executive functions[J]. Handbook of Clinical Neurology, 2020, 173: 225-240.
[2] Doebel S. Rethinking executive function and its development[J]. Perspect Psychol Sci, 2020, 15(4): 942-956.
[3] Hirota T, King BH. Autism spectrum disorder[J]. JAMA, 2023, 329(2): 157.
[4] Lord C, Brugha TS, Charman T, et al. Autism spectrum disorder[J].Nature Reviews Disease Primers, 2020, 6(1): 1-23.
[5] Macoun SJ, Schneider I, Bedir B, et al. Pilot study of an attention and executive function cognitive intervention in children with autism spectrum disorders[J]. J Autism Dev Disord, 2021, 51(8): 2600-2610.
[6] 张航, 辛钊阳, 陈志梅, 等. 3~6岁幼儿移动性动作发展与情绪理解:工作记忆和抑制控制的链式中介作用[J]. 中国临床心理学杂志, 2023, 31(2): 413-416.
Zhang H, Xin ZY, Chen ZM, et al. Development of mobility and emotion understanding in children aged 3-6 years: Chain mediation effect of working memory and inhibitory control[J]. Chin J Clin Psychol, 2023, 31(2): 413-416. (in Chinese)
[7] 阳雨露, 李雪, 刘靖, 等. 高功能孤独症患儿刻板重复行为与认知灵活性和抑制控制能力的关系研究[J]. 中国全科医学, 2019, 22(8): 983-988.
Yang YL, Li X, Liu J, et al. Study on the relationship between stereotyped repetitive behaviors, cognitive flexibility, and inhibitory control ability in children with high-functioning autism[J]. Chin Gen Pract, 2019, 22(8): 983-988. (in Chinese)
[8] 侯耀奇, 宋湘勤. 运动干预改善孤独症谱系障碍儿童社会功能的研究进展[J]. 中国儿童保健杂志, 2024,32(3):291-295.
Hou YQ, Song XQ. Research progress on the improvement of social function in children with autism spectrum disorder through exercise intervention[J]. Chin J Child Health, 2024,32(3):291-295. (in Chinese)
[9] 程燕华, 马博森. 高功能孤独症儿童与普通儿童会话修正行为对比研究[J]. 中国特殊教育, 2022, (2): 28-36, 44.
Cheng YH, Ma BS. Comparative study on conversational repair behaviors between children with high-functioning autism and typical children[J]. Chin Spec Educ, 2022, (2): 28-36, 44. (in Chinese)
[10] Montgomery L, Chondrogianni V, Fletcher-Watson S, et al. Measuring the impact of bilingualism on executive functioning via inhibitory control abilities in autistic children[J]. Journal of Autism and Developmental Disorders, 2022, 52(8): 3560-3573.
[11] 高翔, 黄荣芝, 田俊龙, 等. 中文版儿童执行功能量表在小学生中应用的信效度分析[J]. 中国学校卫生, 2023, 44(7): 1026-1029.
Gao X, Huang RZ, Tian JL, et al. Reliability and validity analysis of the Chinese version of the Child Executive Function Inventory in primary school students[J]. Chin Sch Health, 2023, 44(7): 1026-1029. (in Chinese)
[12] Harsa P, Břeňová M, Bezdíček O, et al. Tower of London test-short version[J]. Neurologia i Neurochirurgia Polska, 2022, 56(4): 365-370.
[13] Van Royen A, Van Malderen E, Desmet M, et al. Go or no-go? An assessment of inhibitory control training using the GO/NO-GO task in adolescents[J]. Appetite, 2022, 179: 106303.
[14] Mar K, Townes P, Pechlivanoglou P, et al. Obsessive compulsive disorder and response inhibition: Meta-analysis of the stop-signal task.[J]. J Psychopathol Clin Sci, 2022, 131(2): 152-161.
[15] Renaud F, Béliveau MJ, Akzam-Ouellette MA, et al. Comparison of the Wechsler Preschool and Primary Scale of Intelligence-Third Edition and the Leiter-R Intellectual Assessments for Clinic-Referred Children[J]. Journal of Psychoeducational Assessment, 2022, 40(7): 825-838.
[16] Llorente AM, Voigt RG, Williams J, et al. Children's Color Trails Test 1 & 2: Test-retest reliability and factorial validity[J]. Clini Neuropsych, 2009, 23(4): 645-660.
[17] Bowden SC, Fowler KS, Bell RC, et al. The Reliability and Internal Validity of the Wisconsin Card Sorting Test[J]. Neuropsychol Rehabil, 1998, 8(3): 243-254.
[18] Davidson MC, Amso D, Anderson LC, et al. Development of cognitive control and executive functions from 4 to 13 years: Evidence from manipulations of memory, inhibition, and task switching[J]. Neuropsychologia, 2006, 44(11): 2037-2078.
[19] Scarpina F, Tagini S. The Stroop Color and Word Test[J]. Front Psychol, 2017, 8.
[20] Hübner R, Töbel L. Conflict resolution in the Eriksen flanker task: Similarities and differences to the Simon task[J].PLoS ONE, 2019, 14(3): e0214203.
[21] Liang X, Li R, Wong SHS, et al. The effects of exercise interventions on executive functions in children and adolescents with autism spectrum disorder: A systematic review and meta-analysis[J]. Sports Med, 2022, 52(1): 75-88.
[22] Sandbakk Ø, Haugen T, Ettema G. The influence of exercise modality on training load management[J]. Int J SportPhysiol, 2021, 16(4): 605-608.
[23] 刘智妹, 蔡可龙, 朱丽娜, 等. 运动干预对孤独症伴有智力低下儿童执行功能及默认网络功能连接的影响[J]. 首都体育学院学报, 2023, 35(5): 493-502.
Liu ZM, Cai KL, Zhu LN, et al. The effect of exercise intervention on executive function and default network functional connectivity in children with autism and intellectual disability[J]. J Capital Univ Phys Educ Sports, 2023, 35(5): 493-502. (in Chinese)
[24] Wang JG, Cai KL, Liu ZM, et al. Effects of mini-basketball training program on executive functions and core symptoms among preschool children with autism spectrum disorders[J]. Brain Sci, 2020, 10(5): 263.
[25] Pan CY, Chu CH, Tsai CL, et al. The impacts of physical activity intervention on physical and cognitive outcomes in children with autism spectrum disorder[J]. Autism, 2017, 21(2): 190-202.
[26] Tse CYA, Lee HP, Chan KSK, et al. Examining the impact of physical activity on sleep quality and executive functions in children with autism spectrum disorder: A randomized controlled trial[J]. Autism, 2019, 23(7): 1699-1710.
[27] Borgi M, Loliva D, Cerino S, et al. Effectiveness of a standardized equine-assisted therapy program for children with autism spectrum disorder[J]. J Autism Dev Disord, 2016, 46(1): 1-9.
[28] Chan AS, Sze SL, Cheung MC, et al. Dejian mind-body intervention improves the cognitive functions of a child with autism[J]. Evid Based Complement Alternat Medi, 2011, 2011: 1-7.
[29] Rafiei Milajerdi H, Sheikh M, Najafabadi MG, et al. The effects of physical activity and exergaming on motor skills and executive functions in children with autism spectrum disorder[J]. Games for Health Journal, 2021, 10(1): 33-42.
[30] Chan AS, Sze SL, Siu NY, et al. A Chinese mind-body exercise improves self-control of children with autism: A randomized controlled trial[J]. PLoS ONE, 2013, 8(7): e68184.
[31] Nekar DM, Lee DY, Hong JH, et al. Effects of augmented reality game-based cognitive-motor training on restricted and repetitive behaviors and executive function in patients with autism spectrum disorder[J]. Healthcare, 2022, 10(10): 1981.
[32] Phung JN, Goldberg WA. Promoting executive functioning in children with autism spectrum disorder through mixed martial arts training[J]. J Autism Dev Disord, 2019, 49(9): 3669-3684.
[33] Tse AC, Liu VH, Lee PH, et al. The relationships among executive functions, self-regulation, and physical exercise in children with autism spectrum disorder[J]. Autism, 2023: 136236132311689.
[34] Anderson-Hanley C, Tureck, Schneiderman. Autism and exergaming: Effects on repetitive behaviors and cognition[J]. Psychol Res Behav Ma, 2011, 4: 129.
[35] Bremer E, Graham JD, Heisz JJ, et al. Effect of acute exercise on prefrontal oxygenation and inhibitory control among male children with autism spectrum disorder: An exploratory study[J]. Front Behav Neurosci, 2020, 14: 84.
[36] Ji CX, Yang J, Lin L, et al. Executive function improvement for children with autism spectrum disorder: A comparative study between virtual training and physical exercise methods[J]. Children-Basel, 2022, 9(4): 12.
[37] Nakutin SN, Gutierrez G. Effect of physical activity on academic engagement and executive functioning in children with ASD[J]. Sch Psychol Rev, 2019, 48(2): 177-184.
[38] Ringenbach SDR, Lichtsinn KC, Holzapfel SD. Assisted cycling therapy (ACT) improves inhibition in adolescents with autism spectrum disorder[J]. J Intellect Dev Dis, 2015, 40(4): 376-387.
[39] Wang S, Chen D, Yang Y, et al. Effectiveness of physical activity interventions for core symptoms of autism spectrum disorder: A systematic review and meta-analysis[J]. Autism Res, 2023, 16(9): 1811-1824.
[40] Dieckelmann M, González-González AI, Banzer W, et al. Effectiveness of exercise interventions to improve long-term outcomes in people living with mild cognitive impairment:A systematic review and meta-analysis[J]. Sci Rep, 2023, 13(1): 18074.
[41] Rezae M, Chen N, McMeekin D, et al. The evaluation of a mobile user interface for people on the autism spectrum: An eye movement study[J]. International Journal of Human-Computer Studies, 2020, 142: 102462.
[42] Moraes ÍAP, Lima JA, Silva NM, et al. Effect of longitudinal practice in real and virtual environments on motor performance, physical activity and enjoyment in people with autism spectrum disorder: A prospective randomized crossover controlled trial[J]. Int J Environ Res Pub Health, 2022, 19(22): 14668.
[43] Munakata Y, Herd SA, Chatham CH, et al. A unified framework for inhibitory control[J]. Trends Cogn Sci, 2011, 15(10): 453-459.
[44] 杨莉, 刘靖, 邹小兵, 等. 孤独症脑科学研究进展2022综述[J]. 中国心理卫生杂志, 2023, 37(4): 293-298.
Yang L, Liu J, Zou XB, et al. Review of the progress in autism neuroscience research in 2022[J]. Chin J Ment Health, 2023, 37(4): 293-298. (in Chinese)
[45] Wu J, Xiao W, Yip J, et al. Effects of exercise on neuralchanges in inhibitorycontrol: An ALE Meta-analysis of fMRI studies[J]. Front Hum Neurosci, 2022, 16.
[46] Niendam TA, Laird AR, Ray KL, et al. Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions[J]. Cogn Affect Behav Ne, 2012, 12(2): 241-268.
[47] Yu Q, Herold F, Becker B, et al. Cognitive benefits of exercise interventions: An fMRI activation likelihood estimation meta-analysis[J]. Brain Struct Funct, 2021, 226(3):601-619.
[48] Mehren A, Özyurt J, Thiel CM, et al. Effects of acute aerobic exercise on response inhibition in adult patients with ADHD[J]. Sci Rep, 2019, 9(1): 19884.