产前应激对子代神经行为的影响

doi:10.11852/zgetbjzz2023-0814

摘要/Abstract

摘要： 妊娠期是女性身体和心理所面临的特殊时期,期间可能经历各种压力带来的应激。持续或严重的产前应激不仅对母体产生不良影响,而且可损害子代大脑结构和功能,增加子代神经心理发育障碍的风险,如抑郁、焦虑、注意缺陷多动障碍、孤独症谱系障碍和学习记忆能力损伤等。本文总结了研究中常用的产前应激动物模型,归纳了产前应激对子代神经行为发育的影响及机制的研究进展,并对未来可能研究方向进行了讨论与展望,以期为产前应激后子代不良神经行为的干预提供新的思路。

关键词: 产前应激, 子代, 神经行为

Abstract: Pregnancy is a special period for women both physically and psychologically, during which they may experience various stressors.Persistent or severe prenatal stress not only adversely affects the mother, but also impairs the offspring′s brain structure and function, increasing the risk of neuropsychological development disorders, such as depression, anxiety, attention deficit hyperactivity disorder, autism spectrum disorder, and learning and memory impairment, etc.This review summarizes the commonly used animal models of prenatal stress, and the research progress on the effects and mechanisms of prenatal stress on the development of offspring.In addition, the possible future research directions are discussed and prospected, so as to provide new ideas for the intervention of adverse neurobehavior in offspring after prenatal stress.

Key words: prenatal stress, offspring, neurobehavior

中图分类号:

R715

袁秋芳, 柳涛. 产前应激对子代神经行为的影响[J]. 中国儿童保健杂志, 2024, 32(7): 762-766.

YUAN Qiufang, LIU Tao. Effects of prenatal stress on the neurobehavioral development of offspring[J]. Chinese Journal of Child Health Care, 2024, 32(7): 762-766.

参考文献

[1] Wu S, Gennings C, Wright RJ, et al.Prenatal stress, methylation in inflammation-related genes, and adiposity measures in early childhood:The programming research in obesity, growth environment and social stress cohort study[J].Psychosom Med, 2018,80(1):34-41.
[2] Boekhorst M, Muskens L, Hulsbosch LP, et al.The COVID-19 outbreak increases maternal stress during pregnancy, but not the risk for postpartum depression[J].Arch Womens Ment Health, 2021,24(6):1037-1043.
[3] Wang S, Ding C, Dou C, et al.Associations between maternal prenatal depression and neonatal behavior and brain function-evidence from the functional near-infrared spectroscopy[J].Psychoneuroendocrinology, 2022,146:105896.
[4] Lautarescu A, Craig MC, Glover V.Prenatal stress:Effects on fetal and child brain development[J].Int Rev Neurobiol, 2020,150:17-40.
[5] Wu Y, Lu YC, Jacobs M, et al.Association of prenatal maternal psychological distress with fetal brain growth, metabolism, and cortical maturation[J].JAMA Netw Open, 2020,3(1):e1919940.
[6] Davis EP, Hankin BL, Glynn LM, et al.Prenatal maternal stress, child cortical thickness, and adolescent depressive symptoms[J].Child Dev, 2020,91(2):e432-e450.
[7] Adamson B, Letourneau N, Lebel C.Prenatal maternal anxiety and Children's brain structure and function:A systematic review of neuroimaging studies[J].J Affect Disord, 2018,241:117-126.
[8] Alexopoulou L, Holt AC, Medzhitov R, et al.Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3[J].Nature, 2001,413(6857):732-738.
[9] Li W, Sun F, Guo X, et al.Behavioral abnormalities and phosphorylation deficits of extracellular signal-regulated kinases 1 and 2 in rat offspring of the maternal immune activation model[J].Physiol Behav, 2020,217:112805.
[10] Sheu JR, Hsieh CY, Jayakumar T, et al.A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis[J].Front Neurosci, 2019,13:635.
[11] Depino AM.Early prenatal exposure to LPS results in anxiety-and depression-related behaviors in adulthood[J].Neuroscience, 2015,299:56-65.
[12] Rahimi S, Peeri M, Azarbayjani MA, et al.Long-term exercise from adolescence to adulthood reduces anxiety-and depression-like behaviors following maternal immune activation in offspring[J].Physiol Behav, 2020,226:113130.
[13] Choi GE, Chae CW, Park MR, et al.Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis[J].Cell Mol Life Sci, 2022,79(6):294.
[14] Suwaluk A, Chutabhakdikul N.Altered development of prefrontal GABAergic functions and anxiety-like behavior in adolescent offspring induced by prenatal stress[J].Brain Sci, 2022,12(8).
[15] Abramova O, Ushakova V, Zorkina Y, et al.The behavior and postnatal development in infant and juvenile rats after ultrasound-induced chronic prenatal stress[J].Front Physiol, 2021,12:659366.
[16] Davis JL, O′connor M, Erlbacher H, et al.The impact of maternal antioxidants on prenatal stress effects on offspring neurobiology and behavior[J].Yale J Biol Med, 2022,95(1):87-104.
[17] Shao S, Yao D, Li S, et al.N-cadherin regulates GluA1-mediated depressive-like behavior in adolescent female rat offspring following prenatal stress[J].Neuroendocrinology, 2022,112(5):493-509.
[18] 贾宁, 孙钦儒, 苏倩.产前应激孕鼠子代抑郁样行为观察及机制探讨[J].山东医药, 2016, 56(27):16-19.
Jia N,Sun QR,SU Q.Observation and mechanism exploration of depression like behavior in offspring of prenatal stress pregnant mice[J].Shandong Pharma,2016,56(27):16-19.(in Chinese)
[19] Zoubovsky SP, Williams MT, Hoseus S, et al.Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment[J].Transl Psychiatry, 2022,12(1):22.
[20] 刘洁, 阿迪莱·麦麦提阿卜杜拉,苏童.产前慢性应激对子代幼年小鼠空间学习记忆能力的影响[J].职业与健康, 2021, 37(2):167-170.
Liu J,Adilai·Maimaitiabudulai,Su T.The effect of prenatal chronic stress on the spatial learning and memory abilities of offspring young mice[J].Occupation and Health,2021,37(2):167-170.(in Chinese)
[21] Moura CA, Oliveira MC, Costa LF, et al.Prenatal restraint stress impairs recognition memory in adult male and female offspring[J].Acta Neuropsychiatr, 2020:1-6.
[22] Block CL, Eroglu O, Mague SD, et al.Prenatal environmental stressors impair postnatal microglia function and adult behavior in males[J].Cell Rep, 2022,40(5):111161.
[23] Manzari N, Matvienko-Sikar K, Baldoni F, et al.Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring:A systematic review and meta-analysis[J].Soc Psychiatry Psychiatr Epidemiol, 2019,54(11):1299-1309.
[24] Fidilio A, Grasso M, Caruso G, et al.Prenatal stress induces a depressive-like phenotype in adolescent rats:The key role of TGF-β1 pathway[J].Front Pharmacol, 2022,13:1075746.
[25] Liao X, Vasilakos AV, He Y.Small-world human brain networks:Perspectives and challenges[J].Neurosci Biobehav Rev, 2017,77:286-300.
[26] Dong E, Guidotti A, Zhang H, et al.Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring[J].Neuropharmacology, 2018,140:76-85.
[27] Neniskyte U, Gross C T.Errant gardeners:Glial-cell-dependent synaptic pruning and neurodevelopmental disorders[J].Nat Rev Neurosci, 2017,18(11):658-670.
[28] Ślusarczyk J, Trojan E, Głombik K, et al.Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells[J].Front Cell Neurosci, 2015,9:82.
[29] De Souza DF, Wartchow KM, Lunardi PS, et al.Changes in astroglial markers in a maternal immune activation model of schizophrenia in wistar rats are dependent on sex[J].Front Cell Neurosci, 2015,9:489.
[30] Hayes LN, An K, Carloni E, et al.Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry[J].Nature, 2022,610(7931):327-334.
[31] Paladini MS, Marangon D, Rossetti AC, et al.Prenatal stress impairs spinal cord oligodendrocyte maturation via BDNF signaling in the experimental autoimmune encephalomyelitis model of multiple sclerosis[J].Cell Mol Neurobiol, 2022,42(4):1225-1240.
[32] Dong Y, Weng J, Zhu Y, et al.Transcriptomic profiling of the developing brain revealed cell-type and brain-region specificity in a mouse model of prenatal stress[J].BMC Genomics, 2023,24(1):86.
[33] Chalfun G, Reis MM, De Oliveira MBG, et al.Perinatal stress and methylation of the NR3C1 gene in newborns:systematic review[J].Epigenetics, 2022,17(9):1003-1019.
[34] Possamai-Della T, Cararo JH, Aguiar-Geraldo JM, et al.Prenatal stress induces long-term behavioral sex-dependent changes in rats offspring:The role of the HPA axis and epigenetics[J].Mol Neurobiol, 2023;60(9):5013-5033.
[35] Hjort L, Rushiti F, Wang SJ, et al.Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels[J].Epigenomics, 2021,13(12):967-980.
[36] Potter HG, Kowash HM, Woods RM, et al.Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNFα concentration in a rat model of neurodevelopmental disorders[J].Brain Behav Immun, 2023,108:162-175.
[37] Chen HJ, Antonson AM, Rajasekera TA, et al.Prenatal stress causes intrauterine inflammation and serotonergic dysfunction, and long-term behavioral deficits through microbe-and CCL2-dependent mechanisms[J].Transl Psychiatry, 2020,10(1):191.
[38] Liu MY, Wei LL, Zhu XH, et al.Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor[J].Mol Psychiatry, 2023,28(3):1383-1395.
[39] Mccreary JK, Metz GAS.Environmental enrichment as an intervention for adverse health outcomes of prenatal stress[J].Environ Epigenet, 2016,2(3):dvw013.