妊娠期睡眠剥夺导致子代认知功能障碍的研究进展

周子愉; 吕靖; 冯光武; 汪新月; 杜书垚; 李清

doi:10.11852/zgetbjzz2023-0695

PDF(541 KB)

中国儿童保健杂志 ›› 2024, Vol. 32 ›› Issue (2) : 169-173. DOI: 10.11852/zgetbjzz2023-0695

综述

妊娠期睡眠剥夺导致子代认知功能障碍的研究进展

周子愉, 吕靖, 冯光武, 汪新月, 杜书垚, 李清

作者信息 +

Research progress on cognitive dysfunction in offspring due to sleep deprivation during pregnancy

ZHOU Ziyu, LYU Jing, FENG Guangwu, WANG Xinyue, DU Shuyao, LI Qing

Author information +

文章历史 +

摘要

睡眠剥夺是自身或外界因素干扰导致的睡眠时间缺失。越来越多的证据表明妊娠期更容易出现睡眠剥夺,其不仅破坏母体机体各个功能,还会影响子代的认知功能。本文将对妊娠期睡眠剥夺对子代认知影响及其中机制进行综述,为制定科学合理的妊娠期睡眠策略提供依据,为改善其子代神经发育及认知功能提供一些临床思路。

Abstract

Sleep deprivation refers to the loss of sleep caused by self-inflicted or external factors. There is increasing evidence that pregnancy is prone to sleep deprivation, which not only disrupts maternal functions but also affects offspring's cognitive function. This article reviews the effects of sleep deprivation during pregnancy on offspring cognition and its underlying mechanisms, in order to establish a foundation for developing scientifically sound sleep strategies during pregnancy and to provide clinical insights for improving the neurodevelopment and cognitive function of offspring.

导出引用

周子愉, 吕靖, 冯光武, 汪新月, 杜书垚, 李清. 妊娠期睡眠剥夺导致子代认知功能障碍的研究进展[J]. 中国儿童保健杂志. 2024, 32(2): 169-173 https://doi.org/10.11852/zgetbjzz2023-0695

ZHOU Ziyu, LYU Jing, FENG Guangwu, WANG Xinyue, DU Shuyao, LI Qing. Research progress on cognitive dysfunction in offspring due to sleep deprivation during pregnancy[J]. Chinese Journal of Child Health Care. 2024, 32(2): 169-173 https://doi.org/10.11852/zgetbjzz2023-0695

中图分类号： R715

参考文献

[1] Rault C, Sangaré A, Diaz V, et al. Impact of sleep deprivation on respiratory motor output and endurance. A physiological study[J].Am J Respir Crit Care Med, 2020, 201(8):976-983.
[2] Pengo MF, Won CH, Bourjeily G. Sleep in women across the life span[J]. Chest, 2018, 154(1):196-206.
[3] Sedov ID, Anderson NJ, Dhillon AK, et al. Insomnia symptoms during pregnancy:A meta-analysis[J]. J Sleep Res, 2021, 30(1):e13207.
[4] Liew SC, Aung T. Sleep deprivation and its association with diseases- a review[J]. Sleep Med, 2021, 77:192-204.
[5] Hedman C, Pohjasvaara T, Tolonen U, et al. Effects of pregnancy on mothers' sleep[J]. Sleep Med, 2002, 3(1):37-42.
[6] Lee KA, Zaffke ME, Mcenany G. Parity and sleep patterns during and after pregnancy[J].Obstet Gynecol,2000, 95(1):14-18.
[7] Bourjeily G. Sleep disorders in pregnancy[J]. Obstet Med,2009, 2(3):100-106.
[8] Peng Y, Wang W, Tan T, et al. Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats[J]. Mol Brain, 2016, 9(1):17.
[9] Chang JJ, Pien GW, Duntley SP, et al. Sleep deprivation during pregnancy and maternal and fetal outcomes:Is there a relationship?[J]. Sleep Med Rev, 2010, 14(2):107-114.
[10] Zhao Q, Peng C, Wu X, et al. Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats[J].Neurobiol Dis, 2014, 68:57-65.
[11] Wei RM, Zhang YM, Li Y, et al. Altered cognition and anxiety in adolescent offspring whose mothers underwent different-pattern maternal sleep deprivation, and cognition link to hippocampal expressions of Bdnf and Syt-1[J].Front Behav Neurosci, 2022, 16:1066725.
[12] Mueller AD, Parfyonov M, Pavlovski I, et al. The inhibitory effect of sleep deprivation on cell proliferation in the hippocampus of adult mice is eliminated by corticosterone clamp combined with interleukin-1 receptor 1 knockout[J].Brain Behav Immun, 2014, 35:182-188.
[13] Ou-Yang P, Cai ZY, Zhang ZH. Molecular regulation mechanism of microglial autophagy in the pathology of alzheimer's disease[J]. Aging Dis, 2023,14(4):1166-1177.
[14] Wu Y, Dong Z, Jiang X, et al. Gut microbiota taxon-dependent transformation of microglial M1/M2 phenotypes underlying mechanisms of spatial learning and memory impairment after chronic methamphetamine exposure[J]. Microbiol Spectr, 2023, 11(3):e00302-23.
[15] Diz-Chaves Y, Astiz M, Bellini M J, et al. Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice[J]. Brain Behav Immun, 2013, 28:196-206.
[16] Zhao Q, Peng C, Wu X, et al. Maternal sleep deprivation inhibits hippocampal neurogenesis associated with inflammatory response in young offspring rats[J].Neurobiol Dis, 2014, 68:57-65.
[17] Zhao Q, Xie X, Fan Y, et al. Phenotypic dysregulation of microglial activation in young offspring rats with maternal sleep deprivation-induced cognitive impairment[J]. Sci Rep, 2015, 5(1):9513.
[18] Han Y, Wang J, Zhao Q, et al. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis[J]. Brain Behav Immun, 2020, 87:568-578.
[19] Magee JC, Grienberger C. Synaptic plasticity forms and functions[J]. Annu Rev Neurosci, 2020, 43(1):95-117.
[20] Neves G, Cooke SF, Bliss TVP. Synaptic plasticity, memory and the hippocampus:A neural network approach to causality[J]. Nat Rev Neurosci, 2008, 9(1):65-75.
[21] Peng Y, Wang W, Tan T, et al. Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats[J]. Mol Brain, 2016, 9(1):17.
[22] Yu Y, Huang Z, Dai C, et al. Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats[J]. Neuropharmacology, 2018, 133:155-162.
[23] Diering GH, Huganir RL. The AMPA receptor code of synaptic plasticity[J]. Neuron, 2018, 100(2):314-329.
[24] Schueller E, Paiva I, Blanc F, et al. Dysregulation of histone acetylation pathways in hippocampus and frontal cortex of Alzheimer's disease patients[J]. Eur Neuropsychopharmacol, 2020, 33:101-116.
[25] Guan JS, Haggarty SJ, Giacometti E, et al. HDAC2 negatively regulates memory formation and synaptic plasticity[J]. Nature, 2009, 459(7243):55-60.
[26] Zhang Y, Wei R, Ni M, et al. An enriched environment improves maternal sleep deprivation-induced cognitive deficits and synaptic plasticity via hippocampal histone acetylation[J]. Brain Behav, 2023, 13(6):e3018.
[27] Plitman E, Iwata Y, Caravaggio F, et al. Kynurenic acid in schizophrenia:A systematic review and meta-analysis[J]. Schizophr Bull, 2017, 43(4):764-777.
[28] Milosavljevic S, Smith AK, Wright CJ, et al. Kynurenine aminotransferase Ⅱ inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult[J]. Transl Psychiatry, 2023, 13(1):106.
[29] Baratta AM, Buck SA, Buchla AD, et al. Sex differences in hippocampal memory and kynurenic acid formation following acute sleep deprivation in rats[J]. Sci Rep, 2018, 8(1):6963.
[30] Baratta AM, Kanyuch NR, Cole CA, et al. Acute sleep deprivation during pregnancy in rats:Rapid elevation of placental and fetal inflammation and kynurenic acid[J]. Neurobiol Stress, 2020, 12:100204.
[31] Notarangelo FM, Pocivavsek A. Elevated kynurenine pathway metabolism during neurodevelopment:Implications for brain and behavior[J]. Neuropharmacology, 2017, 112(Pt B):275-285.
[32] Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, et al. A comprehensive review on the role of the gut microbiome in human neurological disorders[J]. Clin Microbiol Rev, 2022, 35(1):e00338-20.
[33] Wang HX, Wang YP. Gut microbiota-brain axis[J]. Chin Med J(Engl), 2016, 129(19):2373-2380.
[34] Grech A, Collins CE, Holmes A, et al. Maternal exposures and the infant gut microbiome:A systematic review with meta-analysis[J]. Gut Microbes, 2021, 13(1):1-30.
[35] Tochitani S. Vertical transmission of gut microbiota:Points of action of environmental factors influencing brain development[J]. Neurosci Res, 2021, 168:83-94.
[36] Yao ZY, Li XH, Zuo L, et al. Maternal sleep deprivation induces gut microbial dysbiosis and neuroinflammation in offspring rats[J]. Zool Res, 2022, 43(3):380-390.
[37] Cao JY, Dixon SJ. Mechanisms of ferroptosis[J]. Cell Mol Life Sci, 2016, 73(11-12):2195-2209.
[38] Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis:An iron-dependent form of nonapoptotic cell death[J]. Cell, 2012, 149(5):1060-1072.
[39] Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition[J]. Nat Chem Biol, 2017, 13(1):91-98.
[40] Seibt TM, Proneth B, Conrad M. Role of GPX4 in ferroptosis and its pharmacological implication[J]. Free Radic Biol Med, 2019, 133:144-152.
[41] Lv J, Xu S, Meng C, et al. Ferroptosis participated in hippocampal neuroinflammation damage of in offspring rats after maternal sleep deprivation[J]. J Neuroimmunol, 2023, 375:578021.
[42] Onodera J, Nagata H, Nakashima A, et al. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics[J]. Glia, 2021, 69(4):890-904.
[43] Faraguna U, Vyazovskiy VV, Nelson AB, et al. A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep[J]. J Neurosci, 2008, 28(15):4088-4095.
[44] Zuo JX, Li M, Jiang L, et al. Hydrogen sulfide prevents sleep deprivation-induced hippocampal damage by upregulation of sirt1 in the hippocampus[J]. Front Neurosci, 2020, 14:169.
[45] You M, Pan Y, Liu Y, et al. Royal Jelly alleviates cognitive deficits and β-amyloid accumulation in APP/PS1 mouse model via activation of the cAMP/PKA/CREB/BDNF pathway and inhibition of neuronal apoptosis[J]. Front Aging Neurosci, 2019, 10:428.
[46] Khodaverdiloo A, Farhadi M, Jameie M, et al. Neurogenesis in the rat neonate's hippocampus with maternal short-term REM sleep deprivation restores by royal jelly treatment[J]. Brain Behav, 2021, 11(12):e2423.