还原叶酸载体基因A80G多态性与神经管畸形易感性关系的Meta分析

doi:10.11852/zgetbjzz2019-1022

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (7): 774-779.DOI: 10.11852/zgetbjzz2019-1022

还原叶酸载体基因A80G多态性与神经管畸形易感性关系的Meta分析

魏红, 宋希元, 刘雪, 曹慧玲, 孔灵玲, 王旭

济宁医学院基础医学院,山东济宁 272067

收稿日期:2019-09-12 发布日期:2020-07-10 出版日期:2020-07-10
作者简介:魏红(1981-),女,山东人,讲师,硕士学位,主要从事病理学教学与科研工作。
基金资助:
济宁市科技发展计划项目(2013jnwk71);山东省人口和计划生育委员会科学技术项目(2011-20);济宁医学院2011年青年基金项目(JYQ2011KM014)

Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects

WEI Hong, SONG Xi-yuan, LIU Xue, CAO Hui-ling, KONG Ling-ling, WANG Xu

College of Basic Medicine,Jining Medical University,Jining,Shandong 272067,China

Received:2019-09-12 Online:2020-07-10 Published:2020-07-10

摘要/Abstract

摘要： 目的系统评价母亲及子代还原叶酸载体(RFC1)基因A80G多态性与神经管畸形(NTDs)发病风险的相关性,为NTDs的预防提供依据。方法检索从建库到2019年5月在中国生物医学文献数据库、中国期刊全文数据库、万方数据库和PubMed、Embase、Cochrane Library数据库公开发表的有关母亲和/或子代RFC1 A80G多态性与NTDs 易感性相关的病例对照研究,应用RevMan 5.3软件对各文献进行Meta分析。结果 1)有关母亲RFC1 A80G 多态性与NTDs易感性文献的Meta分析显示,亚洲人群中RFC1基因A80G位点GG vs AA、GA vs AA、GG+GA vs AA 和G vs A 各遗传模型与子代NTDs 易感性之间有关联性,OR 值(95%CI)分别为4.13(1.97～8.67)、3.03(1.72～5.32)、3.25 (1.90～5.56)、1.94(1.15～3.28)。2)有关子代RFC1 A80G 多态性与NTDs易感性文献的Meta分析显示,亚洲人群中子代RFC1 A80G位点GG vs AA、GG+GA vs AA 、GG vs GA+AA和G vs A 各遗传模型与NTDs易感性之间有关联性,OR值(95%CI)分别为2.20(1.34～3.63)、1.58(1.02～2.46)、1.89(1.31～2.72)、1.55(1.21～1.98)。结论在亚洲人群中母亲及子代RFC1基因A80G位点多态性是NTDs 发病的遗传易感因素之一。

关键词: 神经管畸形, 基因多态性, 还原叶酸载体基因, Meta分析

Abstract: Objective To systematically evaluate associations between gene polymorphism of maternal and offsprings' reduced folate carrier (RFC1) A80G and the risk of neural tube defects (NTDs),so as to provide evidence for the prevention of NTDs. Methods Case-control study on the correlation between RFC1 A80G polymorphism of maternal and /or offspring' with NTDs were searched in CBM,CNKI,Wan-Fang Data,Pubmed,Embase and Cochrane Library from establishment of the database to May 2019.And RevMan 5.3 software was used to analyze data. Results 1) There was significant association between maternal RFC1 A80G polymorphism and increasing risk of NTDs in Asia (GG vs.AA:OR=4.13,95%CI:1.97―8.67;GA vs.AA:OR=3.03,95%CI:1.72―5.32;GG+GA vs.AA:OR=3.25,95%CI:1.90―5.56;G vs.A:OR=1.94,95%CI:1.15―3.28).2) There was significant association between offsprings' RFC1 A80G poly morphism and increasing risk of NTDs in Asia (GG vs.AA:OR=2.20,95%CI:1.34―3.63;GG+GA vs.AA:OR=1.58,95%CI:1.02―2.46;GG vs.GA+AA:OR=1.89,95%CI:1.31―2.72;G vs.A:OR=1.55,95%CI:1.21―1.98). Conclusion Both maternal and offsprings' RFC1 A80G polymorphism are risk factors of NTDs in Asian population.

Key words: neural tube defects, gene polymorphism, reduction folate carrier gene, Meta-analysis

中图分类号:

R394

魏红, 宋希元, 刘雪, 曹慧玲, 孔灵玲, 王旭. 还原叶酸载体基因A80G多态性与神经管畸形易感性关系的Meta分析[J]. 中国儿童保健杂志, 2020, 28(7): 774-779.

WEI Hong, SONG Xi-yuan, LIU Xue, CAO Hui-ling, KONG Ling-ling, WANG Xu. Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects[J]. journal1, 2020, 28(7): 774-779.

参考文献

[1] 张春红,霍军生,孙静,等.母亲MTRR和 MTR基因多态性与子代神经管畸形易感性Meta分析[J].中国预防医学杂志,2018,19(10):726-733.
[2] Dufficy L,Naumovski N,Ng X,et al.G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population[J].Life Sci,2006,79(10):957-966.
[3] De Marco P,Calevo MG,Moroni A,et al.Polymorphisms in genes involved in folate metabolism as risk factors for NTDs[J].Eur J Pediatr Surg,2001,11 (Suppl 1):14-17.
[4] Morin I,Devlin AM,Leclerc D,et al.Evaluation of genetic variants in the reducedfolate carrier and in glutamate carboxypeptidase II for spina bifida risk[J].Mol Genet Metab,2003,79(3):197-200.
[5] Relton CL,Wilding CS,Pearce MS,et al.Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population[J].J Med Genet,2004,41(4):256-260.
[6] O′leary VB,Pangilinan F,Cox C,et al.Reduced folate carrier polymorphisms and neural tube defect risk[J].Mol Genet Metab,2006,87(4):364-369.
[7] Shang Y,Zhao H,Niu B,et al.Correlation of polymorphism of MTHFRs and RFC-1 genes with neural tube defects in China[J].Birth Defects Res,2008,82(1):3-7.
[8] Pei L,Liu J,Zhang Y,et al.Association of reduced folate carrier gene polymorphism and maternal folic acid use with neural tube defects[J].Am J Med Genet A,2009,150B(6):874-878.
[9] Green RF,Byrne J,Crider KS,et al.Folate-related gene variants in Irish families affected by neural tube defects[J].Front Genet,2013,6(4):223.
[10] 郭丽,解军.基因RFC-1多态性与神经管畸形发生的相关性研究[J].山西职工医学院学报,2014,24(6):4-6.

[11] Shaw GM,Lammer EJ,Zhu H,et al.Maternal periconceptional vitamin use,genetic variation of infant reduced folate carrier (A80G),and risk of spina bifida[J].Am J Med Genet A,2002,108(1):1-6.
[12] Cao L,Wang Y,Zhang R,et al.Association of neural tube defects with gene polymorphisms in one-carbon metabolic pathway[J].Childs Nerv Syst,2018,34(2):277-284.
[13] Tolner B,Roy K.Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity[J].Gene,1998,211(2):331-341.
[14] 王懿征,舒剑波,方玉莲,等.BHMT和RFC1多态性与中国北方汉族儿童神经管畸形的易感性研究[J].天津医药,2018,46(9):942-947.
[15] Pei L,Zhu H,Ye R,et al.Interaction between the SLC19A1 gene and maternal first trimester fever on offspring neural tube defects[J].Birth Defects Res,2015,103(1):3-11.
[16] Bassuk AG.Genetic basis of neural tube defects[J].Semin Pediatr Neurol,2009,16(3):101-110.
[17] Zhang T,Lou J,Zhong R,et al.Genetic Variants in the Folate Pathway and the Risk of Neural Tube Defects:A Meta-Analysis of the Published Literature[J].PLoS One,2013,8(4):e59570.
[18] Wang HG,Wang JL,Zhang J,et al.Reduced folate carrier A80G polymorphism and susceptibility to neural tube defects:a meta-analysis[J].Gene,2012,510(2):180-184.
[19] Stanisławska-Sachadyn A,Mitchell LE,Woodside JV,et al.The reduced folate carrier (SLC19A1) c80G>A polymorphism is associated with red cell folate concentrations among women[J].Ann Hum Genet,2009,73(5):484-491.
[20] 罗丽,陈岳明,王贤军.叶酸代谢基因多态性与出生缺陷的关系[J].国际妇产科学杂志,2015,42(4):421-424.

还原叶酸载体基因A80G多态性与神经管畸形易感性关系的Meta分析

Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	鲁果果, 黄晓金, 李国华, 赵永利. 青少年血清维生素D水平与非酒精性脂肪性肝病相关性的Meta分析[J]. 中国儿童保健杂志, 2024, 32(8): 897-901.
[2]	许婷, 刘鹏鸿, 李树峰, 高胜利, 刘丽霞. 网络认知行为疗法对青少年抑郁症状疗效Meta分析[J]. 中国儿童保健杂志, 2024, 32(7): 778-784.
[3]	宰伟仪, 徐宁, 吴伟, 王月莹. 不同康复疗法改善痉挛型脑瘫患儿运动功能障碍疗效的网状Meta分析[J]. 中国儿童保健杂志, 2024, 32(5): 543-551.
[4]	蔚然, 孔锐, 关陆阳, 王永露, 叶侃. 益生菌对孤独谱系障碍患者核心症状干预效果的荟萃分析[J]. 中国儿童保健杂志, 2024, 32(3): 322-328.
[5]	武华红, 书文, 余程东, 张亚钦, 吴婷, 宗心南. 补钙对儿童身高影响的随机对照研究Meta分析[J]. 中国儿童保健杂志, 2024, 32(11): 1246-1251.
[6]	黎帅, 黄启军, 夏宇, 刘振寰. 父母孕产期及环境危险因素与儿童孤独症发生关系的Meta分析[J]. 中国儿童保健杂志, 2024, 32(10): 1122-1127.
[7]	姜妍琳, 王俊宏, 李佳琳, 翟睿, 蒋秀蕾. 中国儿童抽动障碍患病风险预测评分系统构建:基于Meta分析及外部验证[J]. 中国儿童保健杂志, 2024, 32(10): 1128-1134.
[8]	姜妍琳, 张蔷, 翟睿, 彭雅琪, 太然, 王俊宏. 中国儿童抽动障碍患病率及危险因素系统评价[J]. 中国儿童保健杂志, 2023, 31(6): 661-667.
[9]	李嘉, 张延赤. 维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 516-520.
[10]	尹翠平, 王楠, 刘然. 儿童青少年骨折发生影响因素的剂量-反应Meta分析[J]. 中国儿童保健杂志, 2023, 31(5): 529-534.
[11]	叶夕霞, 朱之心, 陈明明, 张雅琴, 周静, 曹文婷. 儿童与青少年血清维生素D水平与骨折风险相关性研究的Meta分析[J]. 中国儿童保健杂志, 2023, 31(4): 416-421.
[12]	林欢喜, 刘潘婷, 童梅玲, 池霞, 钱君, 洪琴. 父母介导的干预在孤独症谱系障碍治疗中应用效果的Meta分析[J]. 中国儿童保健杂志, 2023, 31(3): 304-310.
[13]	沈富辉, 尹立琴, 王凡. 高同型半胱氨酸致神经管畸形的研究进展[J]. 中国儿童保健杂志, 2023, 31(2): 176-179.
[14]	王旭, 王书影, 黎历, 邹映雪. 毛细支气管炎后复发喘息危险因素的Meta分析[J]. 中国儿童保健杂志, 2023, 31(2): 190-194.
[15]	毕小羽, 朱笑彤, 朱飞龙, 匡冬青, 盛思颖, 任园春. 运动干预对注意缺陷多动障碍患儿动作技能影响的Meta分析[J]. 中国儿童保健杂志, 2023, 31(12): 1345-1352.