胰岛素样生长因子1在孤独症谱系障碍中的研究进展

doi:10.11852/zgetbjzz2018-1095

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)确诊主要采用现有行为学症状诊断方法,大多数ASD儿童在到了4岁左右才得到准确诊断,而此时患儿的社交障碍已经十分明显,错失了干预治疗的最佳时期。值得注意的是,国内外学者对ASD的病理机制和药物靶标进行了大量研究,越来越多结果表明胰岛素样生长因子-1(IGF-1)在ASD的发生发展中占据重要地位。本文针对IGF-1在ASD中的作用进行综述,目的是为阐明IGF-1有望成为ASD早期诊断、早期治疗的生物标志物及探讨IGF-1在ASD中的应用前景。

关键词: 孤独症谱系障碍, 胰岛素样生长因子-1, SHANK3基因, Engrailed2基因, MECP2蛋白

Abstract: The diagnosis of autism spectrum disorder (ASD) is mainly dependent on behavioral symptoms,and most children could not receive accurate diagnosis until 4 years old when the impairment of social interaction presents typically and the best period of intervention has been missed. It is worth noting that scientists have made a lot of theoretical and practical research on the pathological mechanism and drug target of ASD. And more and more studies have shown that the biomarker,insulin-like growth factor-1 (IGF-1),plays an important role in the development and progression in ASD. This review will summarize the role of IGF-1 in ASD in order to elucidate that IGF-1 is expected to be a biomarker of early diagnosis and early prevention of ASD,and to explore the application of IGF-1.

Key words: autism spectrum disorder, insulin-like growth factor-1, SHANK3 gene, Engrailed2 gene, MECP2 protein

中图分类号:

R749.94

洪晓文综述, 陈燕惠审校. 胰岛素样生长因子1在孤独症谱系障碍中的研究进展[J]. 中国儿童保健杂志, 2019, 27(1): 56-58.

HONG Xiao-wen, CHEN Yan-hui. Advance on insulin-like growth factor-1 in autism spectrum disorders[J]. journal1, 2019, 27(1): 56-58.

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