Objective To study the influencing factors of care-seeking and medication on children with attention deficit hyperactivity disorder(ADHD), to improve compliance of medication and prognosis. Methods All patients diagnosed and prescribed medicine at first time as ADHD in mental health department during May 2008 to May 2011.General information and psychological test were administered at the same time, retrospective interviews by self-designed questionnaire on July.2012. Results There were 699 ADHD patients, 490 patients were successfully followed, 453 patients(92.45%) accepted methylphenidate hydrochloride(MPH) therapy, 185 patients (37.75%) had good compliance.178 patients insisted on taking the medicine for more than 6 months.Earlier age of care-seeking of children with ADHD was related to education degree of mother(r=-0.140, P<0.01), full intelligence quotient(r=-0.089, P<0.05) and ADHD subtype(r=-0.092, P<0.05).The main three causes for families to stop medication were afraid of the side effects of drugs, behavior problems could not be improved, irregular use of drugs.Compliance of medication was influenced by psychological education (Waldχ²=6.148, P<0.05)and parents 'views on medication(Waldχ²=3.785, P<0.05). Conclusions Low education degree of mother with ADHD children, low score of full intelligence quotient and combined ADHD are related to earlier age of care-seeking.The compliance of medication in ADHD families is low, psychological education and changing views on medication may be helpful.