Objective To investigate the prevalence of metabolic syndrome in obese children and adolescents and the clinical characteristic in outpatient. Method According to the newest diagnosis criteria of metabolic syndrome in children in China, the databases of the clinical and experimental characteristics in simple obesity children and adolescents diagnosed from 2008 to 2010 in the First Affiliated Hospital of SUN Yat-sen University were analysed. Results Eighty-eight patients with simple obesity were enrolled in the study, 63 were above 10 years old 60 had at least one component of metabolic syndrome, 8 (12.7%) were diagnosed as metabolic syndrome, 28 (44.44%) had one component, 24 (38.09%) had 2 components.Among 88 obese children, 25 were aged 6 to 10 year-old, of which, 11 (44%) had cardiovascular risk factors. Conclusions Obese children in outpatient has high prevalence of the metabolic syndrome.There are high prevalences of insulin resistance, hyperinsulinemia and impaired fasting glucose in patients with the metabolic syndrome.
Key words
obesity /
metabolic syndrome /
insulin resistance /
child
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 李辉, 季成叶, 宗心南, 等.中国0~18岁儿童、青少年体块指数的生长曲线[J].中华儿科杂志, 2009, 47(7):493-498.
[2] 季成叶, 马军, 何忠虎, 等.中国汉族学龄儿童青少年腰围正常值[J].中国学校卫生, 2010, 31(3):257-259.
[3] 中华医学会儿科学分会内分泌遗传代谢学组.中国儿童青少年代谢综合征定义和防治建议[J].中华儿科杂志, 2012, 50(6):420-422.
[4] Ten S, Maclaren N.Insulin resistance syndrome in children[J].J Clin Endocrinol Metab, 2004, 89(6):2526-2539.
[5] 梁黎, 傅君芬, 杜军保.中国儿童青少年代谢综合征定义的探索及意义[J].中华儿科杂志, 2012, 63(5):401-404.
[6] 陈雪峰, 梁黎, 傅君芬, 等.中国儿童青少年形体测量学指数调查[J].中华流行病杂志, 2012, 33(5):449-454.
[7] 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志, 2006, 14(3):161-163.
[8] Keskin M, Kurtoglu S, Kendirci M, et al.Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese child and adolescents[J].Pediatrics, 2005, 115:500-503.
[9] Goran MI, Gower BA.Longitudinal study on pubertal insulin resistance[J].Diabetes, 2001, 50:2444-2450.
[10] Love-Osborne K, Butler N, Gao D, et al.Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes[J].Pediatr Diabetes, 2006, 7(4):205-210.