Association study of the IMMP2L and DOCK4 genes polymorphisms with autism in Chinese Han population.

ZOU Ming-yang; LIANG Shuang; GAO Jing-quan; ZHOU Yan-juan; HAO Yan-qiu; WANG Xue-lai; WU Li-jie.

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Chinese Journal of Child Health Care ›› 2014, Vol. 22 ›› Issue (3) : 264-267.

Association study of the IMMP2L and DOCK4 genes polymorphisms with autism in Chinese Han population.

ZOU Ming-yang¹, LIANG Shuang¹, GAO Jing-quan¹, ZHOU Yan-juan¹, HAO Yan-qiu², WANG Xue-lai¹, WU Li-jie¹.

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Abstract

Objective To investigate the association between single nucleotide polymorphisms (SNPs) of the IMMP2L and DOCK4 genes and childhood autism. Methods A total of 375 Chinese Han autism families (parent-parent-child trios) were recruited for this study.SNPS were genotyped using the SNaPshot method, and then analyzed the allele and genotype of rs12537269 and rs1528039 in IMMP2L gene, as well as rs2217262 in DOCK4 gene.Transmission/disequilibrium test (TDT) analysis was used in all nucleus families. Results TDT did not show significantly biased transmission of two different alleles from parents to affected patients as rs12537269 and rs1528029 (P>0.05), but there was significant transmission disequilibrium(χ²=5.343, P=0.021)for rs2217262 polymorphism.The rate of allele A transmitted from heterozygous parents to offspring was higher than that of transmitted C. Conclusion This study shows a possibility of linkage association between autism and DOCK4 gene polymorphism in Chinese Han population.

Key words

autism / Chinese Han population / gene polymorphisms / transmission/disequilibrium test

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ZOU Ming-yang, LIANG Shuang, GAO Jing-quan, ZHOU Yan-juan, HAO Yan-qiu, WANG Xue-lai, WU Li-jie.. Association study of the IMMP2L and DOCK4 genes polymorphisms with autism in Chinese Han population.[J]. Chinese Journal of Child Health Care. 2014, 22(3): 264-267

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