Objective To explore the correlation between food IgG specificity and henoch-schonlein purpura (HSP) in children and the correlation between renal injury in henoch-schonlein purpura nephritist (HSPN). Method The levels of IgG against 14 common food were measured by ELISA and the serum total IgG by automatic biochemical analyzer immunoturbidimetry were obtained from 140 children with HSP. Results Total positive rate of serum food-intolerant IgG antibodies in HSP children was 91.43%.Among these 14 intolerant foods, the positive percentage of egg was the highest(30.4%), followed by milk(26.52%), morrhua (12.17%), crab (7.54%) and shrimp(6.08%).The sort of intolerant food differed between different age groups.But significant differences of the food intolerance positive rate did not exist among different age groups.There was no linear correlation between total food intolerance and serum IgG level.The difference of food intolerance between HSP and HSPN were not statistically significant.Food intolerance had no relation to immune complex deposition in kidneys of HSP nephritis. Conclusions HSP is closely related to food intolerance, but it seems that food intolerance has no relation to renal damage.