Objective To analyse the related factors of influence to children with congenital hypothyroidism (CH) after treatment outcome,and to provide the basis for judging treatment outcome. Methods By grouping comparison,in the statistical chi-square analysis,to retrospectively analyse and summarize the possible related factors of 424 cases of children with CH after standard treatment.To analyse the related factors of influence to children with CH after treatment outcome using Logistic multivariate regression analysis. Results There were statistically significant differences between the two groups of the abnormal thyroid after color Doppler ultrasound checked (suggest thyroid dysplasia)(P<0.01),no significant differences was found among gender groups,the groups whether concurrent hypoxic-ischemic encephalopathy (HIE),the high blood bilirubin groups,and the groups of thyroid-stimulating hormone (TSH) outliers when confirmed,the differences between the corresponding two groups were not statistically significant (P>0.05). Conclusion It is found that the treatment outcome for children with CH should be concerned with thyroid dysplasia at birth,and shouldn't be concerned with gender,HIE,high blood bilirubin at birth and the outliers of TSH when confirmed.Color Doppler ultrasound checked for thyroid at born can help to predict the outcome after treatment.