Objective To explore the effects of early classification,assessment and comprehensively treatment of cerebral palsy (CP) high-risk infants,and to provide scientific and effective evidences for reducing the local incidence of CP and the dysfunction degree of disabled children. Methods The referral system of Nantong was used to screen CP high-risk infants from newborns in Nantong between January 1^st,2011 and December 31^st,2011.Neuro exams and early classification were conducted among them according to PDMS-2 scale.CP high-risk infants with neurological abnormal and the total motor quotient ( TMQ )<80 were divided into two groups after approval from parents:conventional group and early intervention group.Early education and comprehensive intervention were given to each child and regular evaluations were made after 3,6,9 months and 12 months. Results Among all of the high-risk infants,7 cases were eventually confirmed CP,the incidence was 3.4‰,which was far less than national CP incidence of 7.8‰ and local incidence of 8.1‰ in Nantong area.The incidence of CP in early intervention group was significantly lower than that in conventional group (P<0.05 ).Many factors influenced the effects of early comprehensive intervention for CP high-risk infants.Among them,low birth weight and hyperbilirubinemia were the most important (P<0.05 ). Conclusions Early classification and comprehensive intervention of children with CP risks can help reduce the incidence of cerebral palsy.