Effect of lactase activity and intestinal microflora on infant's weight gain
- YAN Yin-mei1,ZHANG Yan1,YAN Yu-jing2,TANG Hua1,BAI Ling1,LU Chun1,WANG Ke1
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Abstract
Objective To investigate the effect of lactase activity and intestinal microflora on infant's weight gain,and the change of weight increasing rate after lactase and probiotics therapy. Methods From 2011 June to 2012 August,97 cases of infants (52 males,45 females) under 42 days were randomly collected from outpatients section.The experimental group were 58 cases of frail infants (33 males,25 females) whose weight increase in the first month of birth were less than 600 g; The control group were 32 cases of normal infants (19 males,13 females) volunteered by parents.They were given urinary galactose and fecal intestinal flora test.The experimental group was given the lactase and probiotics treatment and their weight increase were observed one month later. Results The positive rate of urinary galactose test for experimental group was much higher than control group (P<0.005) and intestinal flora showed disorder (P<0.01),indicating that experimental group had low lactase activity and intestinal flora disturbance.After a month of therapy,all the infants in experimental group had intestinal flora>10∶1,and the increase of weight had no significant difference with control group (P>0.05).This was the evidence of their recovery of intestinal function and their rates of weight increase keep up with the control group.Therefore,the therapy of treating frail infants with lactase and double probiotics was proved to be effective. Conclusions One of the reasons of low weight increase rate of frail infants is the low lactase activity and intestinal flora imbalance.It is effective to supple lactase and probiotics.
Key words
lactase activity / intestinal flora / growth rate / lactase / probiotics
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References
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[2] Campbell AK,Matthews SB,Vassel N,et al.Bacterial metabolic 'toxins':a new mechanism for lactose and food intolerance,and irritable bowel syndrome[J].Toxicology,2010,278(3):268-276.
[3] Hutyra T,Iwańczak B.Determination of milk and diary products consumption and their connection with lactose malabsorption or lactose intolerance in selected disorders of the alimentary tract in children[J].Polski Merkuriusz Lekarski:Organ Polskiego Towarzystwa Lekarskiego,2009,26(152):110-116.
[4] Heyman MB,Committee on Nutrition.Lactose intolerance in infants,children,and adolescents[J].Pediatrics,2006,118(3):1279-1286.
[5] Liverpool UK,Chong CK,Bunn J,et al.Lactose intolerance in infants:harder to investigate now following discontinuation of Clinitest[J].P Arch Dis Child,2010,96(6):611-615.
[6] Novillo A,Peralta D,Dima G,et al.Frequency of bacterial overgrowth in patients with clinical lactose intolerance[J].Acta Gastroenterol,Latinoam,2010,40(3):221-224.
[7] He T,Priebe MG,Zhong Y,et al.Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects[J].Appl Microbiol,2008,104(2):595-604.
[8] Zhao J,Fox M,Cong Y,et al.Lactose intolerance in patients with chronic functional diarrhoea:the role of small intestinal bacterial overgrowth[J].Alimentary Pharmacology & Therapeutics,2010,31(8):892-900.
[9] Asma A,Michael D,Brent C,et al.Systematic review:effective management strategies for lactose intolerance[J].Annals of Internal Medicine,2010,152(12):797-803.
[10] Ibarra A,Acha R,Calleja MT,et al.Optimization and shelf life of a low-lactose yogurt with lactobacillus rhamnosus HN001[J].Dairy Sci,2012,95(7):3536-3548.
[11] Zhong Y,Priebe RJ,Vonk CY,et al.The role of colonic microbiota in lactose intolerance[J].Dig Dis Sci,2004,49:78-83.
[12] Shaukat A,Levitt BC,Taylor R,et al.Systematic review:Effective management strategies for lactose intolerance[J].Ann Intern Med,2010,152:797-803.
[13] Ospedale S,Perino A,Cabras S,et al.Lactose intolerance:a non-allergic disorder often managed by allergologists[J].Eur Ann Allergy Clin Immunol,2009,41(1):3-16.
[14] Hu X,Robin S,O'Connell S,et al.Engineering of a fungal beta-galactosidase to remove product inhibition by galactose[J].Appl Microbiol Biotechnol,2010,87(5):1773-1782.
[15] Ibrahim SA,Alazzeh AY,Awaisheh SS,et al.Enhancement of alpha- and beta-galactosidase activity in Lactobacillus reuteri by different metalions[J].Biol Trace Elem Res,2010,136(1):106-116.
[16] Almeida CC,Lorena SL,Pavan CR,et al.Beneficial effects of long-term consumption of a probiotic combination of Lactobacillus case Shirota and Bifidobacterium breve Yakult may persist after suspension of therapy in lactose-intolerant patients[J].Nutr Clin Pract,2012,27(2):247-251.
