Objective To investigate the correlation between the maternal serum sialic acid (SA) contents,umbilical cord serum SA contents,SA placenta transport rate with infant early growth and development. Methods Prospective cohort study was carried from early pregnancy,followed up to middle,late pregnancy and delivery.The relationships between maternal serum sialic acid at three stages of pregnancy,with offspring birth weight,height,head circumference and Kaup index were carried out. Results There were no significant differences in the neonatal birth weight,birth length,birth head circumference and Kaup index respectively in different serum SA contents in early pregnancy,middle pregnancy and late pregnancy(P>0.05).And there were no significant differences of umbilical cord serum SA and SA placenta transfer rate on neonatal outcome either(P>0.05). Conclusions There are no significant effects of maternal serum SA contents during pregnancy,fetal umbilical cord SA levels and SA placenta transfer rate on birth physical growth.SA doesn't cause obesity to infants.SA placenta transport rate can reflect the nutritional needs for fetal growth and development.
Key words
serum /
sialic acid /
physical growth /
neonatal
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References
[1] Barker DJ.Fetal programming of coronary heart disease[J].Trends in Endocrinology and Metabolism,2002,13(9):364-368.
[2] Barker DJ.The developmental origins of adult disease[J].J Am Coll Nutr,2004,23(S6):588-595.
[3] Barker DJ.The developmental origins of chronic adult disease[J].Acta Paediatrica,2007,93(446):26-33.
[4] 古桂雄,戴耀华.儿童保健学[M].北京:清华大学出版社,2011:10-12.
[5] Brusés JL,Rutishauser U.Roles,regulation,and mechanism of polysialic acid function during neural development[J].Biochimie,2001,83(7):635-643.
[6] Rutishauser U.Polysialic acid in the plasticity of the developing and adult vertebrate nervous system[J].Nat Rev Neurosci,2008,9(1):26-35.
[7] Wang B.Sialic acid is an essential nutrient for brain development and cognition[J].Annu Rev Nutr,2009,29(1):177-222.
[8] Cunningham FG,Leveno KJ,Bloom SL,et al.Williams Obstetrics[M].23rd Edition.The McGraw-Hill Companies,Inc,2009,2:78-95.
[9] Findik RB,Yilmaz FM,Yilmaz G,et al.Sialic acid levels in the blood in pregnant women with impaired glucose tolerance test[J].Arch Gynecol Obstet,2012,286(4):913-916.
[10] Hildebrandt H,Mühlenhoff M,Gerardy-Schahn R.Polysialylation of NCAM[J].Adv Exp Med Biol,2010,663:95-109.
[11] Yang P,Major D,Rutishauser U.Role of charge and hydration in effects of polysialic acid on molecular interactions on and between cell membranes[J].Biological Chemistry,1994,269 (37):23039-23044.
[12] Schnaar RL.Brain gangliosides in axon-myelin stability and axon regeneration[J].FEBS Lett,2010,584(9):1741-1747.
[13] Galan HL,Marconi AM,Paolini CL,et al.The transplacental transport of essential amino acids in uncomplicated human pregnancies[J].Am J Obstet Gynecol,2009,200(1):91-96.
[14] Wan Y,Choi K,Kim S,et al.Hydroxylated polybrominated diphenyl ethers and bisphenol A in pregnant women and their matching fetuses:placental transfer and potential risks[J].Environ Sci Technol,2010,44(13):5233-5239.
[15] Van den Hooven EH,Pierik FH,de Kluizenaar Y,et al.Air pollution exposure during pregnancy,ultrasound measures of fetal growth,and adverse birth outcomes:a prospective cohort study[J].Environmental Health Perspectives,2012,120(1):150-156.
[16] Ludwig DS,Currie J.The association between pregnancy weight gain and birthweight:a within-family comparison[J].The Lancet,2010,376(9745):984-990.
[17] Thompson JM,Wall C,Becroft DM,et al.Maternal dietary patterns in pregnancy and the association with small-for-gestational-age infants[J].British Journal of Nutrition,2010,103(11):1665-1673.
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