Objective To evaluate the clinical efficacy of methylprednisolone combined with interferon for bronchiolitis. Methods A total of 182 patients with bronchiolitis were randomly divided into two groups:the control group of 91 patients were treated with anti-infectives,cough suppressants,expectorants,and oxygen therapy.The treatment group of 91 cases were received conventional treatment and methylprednisolone (1~2mg/kg,2~3 times /d for 3 days,reduction after 3 days) combined with interferon(1.0 μg /kg,one time/d for 3~5 days).The symptoms and signs were observed before and after the treatment. Results In the treatment group,the efficiency rate was 97.6%:in the control group,the efficiency rate was 82.4 %.There was a significant difference between the two groups in efficiency(P<0.01).Relieving wheezing,breathing difficulty,reduced cough time,and ablscultatory wheezing disappearing time were shorter in the treatment group compared to the control group(P<0.01). Conclusion Methylprednisolone combined with interferon for bronchiolitis is safe and help reduce healing time.